Semi Amaryl 05 Mg Tablet 30

Semi Amaryl Tablet 30

Sanofi India Ltd.

Strip of 30 Units

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₹5.24/Units

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Composition

Glimepiride (0.5 Mg)

Strength:

1 MG 2 MG 0.5 MG 3 MG

Semi-Amaryl Tablet is primarily used to manage type 2 diabetes mellitus. It is part of a group of medicines known as sulfonylureas, vital in handling blood sugar levels when diet and exercise alone aren't enough.

Beyond the main use, this tablet plays a significant role in preventing complications linked to diabetes. These complications can include kidney damage, blindness, nerve problems, loss of limbs, and even sexual function issues. By maintaining blood sugar levels, this medicine also reduces your risk of suffering a heart attack or stroke.

Before starting on this medicine, it's crucial that you consult your doctor for the correct dosage and frequency. Make sure to inform your doctor about any pre-existing conditions or ongoing medications you might be using. If you notice any side effects while on this medicine, notify your doctor immediately. Always remember to continue taking the medicine for the duration prescribed by your doctor for the best results.

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Semi-Amaryl Tablet is used for the following:

Assisting in the management of type 2 diabetes mellitus: This medicine helps to control your blood sugar levels when diet and regular exercise are not sufficient.
Preventing complications associated with diabetes: By controlling your blood sugar levels, Semi-Amaryl Tablet can help avoid problems such as kidney damage, loss of limbs, nerve issues, and blindness.
Reducing the risk of heart conditions: Semi-Amaryl Tablet may also help lower the chances of experiencing a heart attack or stroke by efficiently managing blood sugar levels.

Directions for Use of Semi Amaryl Tablet 30

Follow these instructions while taking Semi-Amaryl Tablet:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
Take this medicine with breakfast or your first main meal of the day.
Avoid consuming alcohol as it can increase the risk of low blood sugar (hypoglycemia).
It's crucial not to stop taking this medicine without consulting your doctor first.

Follow these instructions while taking Semi-Amaryl Tablet:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
Take this medicine with breakfast or your first main meal of the day.
Avoid consuming alcohol as it can increase the risk of low blood sugar (hypoglycemia).
It's crucial not to stop taking this medicine without consulting your doctor first.

Semi-Amaryl Tablet may have the following common side effects:

Hypoglycaemia
Headache
Nausea
Dizziness
Hemolytic Anaemia: This is a condition where your body destroys red blood cells faster than it can make them, leading to fatigue and weakness.
Anaphylaxis: This is a severe allergic reaction which can cause breathing difficulties and can be life-threatening.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Semi-Amaryl Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypoglycaemia: Always carry glucose tablets, gel or liquid with you to manage sudden drops in blood sugar levels.
Nausea: Try taking Semi-Amaryl Tablet with food or milk to minimise feelings of nausea.

Semi-Amaryl Tablet contains glimepiride (0.5mg). Here's how it works:

Stimulates Insulin Release: Glimepiride stimulates your pancreas to produce more insulin. The pancreas is a vital organ that helps regulate your blood sugar levels.
Binds to Sulfonylurea Receptor: Glimepiride attaches itself to a specific receptor on the membrane of your pancreas' beta cells, known as the sulfonylurea receptor.
Regulates Potassium Channels: By binding to the sulfonylurea receptor, glimepiride manages the movement of potassium ions in and out of the beta cells. This process is essential for the proper functioning of these cells.
Increases Intracellular Calcium: The regulation of potassium channels leads to an increase in calcium levels within the beta cells. This increase in calcium stimulates the secretion of insulin.

Pregnancy

Caution is advised while taking Semi-Amaryl Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss with your doctor before starting Semi-Amaryl Tablet.

Alcohol

You should avoid alcohol while on this medication as it can enhance the risk of low blood sugar (hypoglycaemia).

Liver

For those with liver issues, caution is recommended when taking Semi-Amaryl Tablet. Talk to your doctor and let them know about any liver conditions you may have.

Kidney

If you have a history of kidney problems, it's advisable to consult your doctor before starting this medicine.

Using Machines & Driving

Semi-Amaryl Tablet can cause dizziness, so caution is advised when driving or operating heavy machinery.

Allergy

This medicine is contraindicated in patients with hypersensitivity to glimepiride or sulfonylureas. If you've had allergic reactions to similar medicines, inform your doctor.

Children

Semi-Amaryl Tablet is not recommended for children. Always consult a doctor before giving any medicine to a child.

Older Patients

Older patients should take Semi-Amaryl Tablet under medical supervision as they may be more susceptible to its side effects, including hypoglycaemia. If you're above 65 years of age, discuss with your doctor who will guide you based on your health status.

Drug-Drug Interactions

Semi-Amaryl Tablet interacts with the following medicines:

Anti-diabetic Agents: When taken together with other diabetes medicines such as metformin, Semi-Amaryl Tablet may intensify the risk of low blood glucose levels (hypoglycemia).
ACE Inhibitors: Medications like lisinopril or enalapril may enhance the glucose-lowering effect of Semi-Amaryl Tablet, potentially leading to hypoglycemia.
NSAIDs and Salicylates: Medicines like ibuprofen and aspirin could increase the risk of hypoglycemia when used alongside Semi-Amaryl Tablet.
Fibrates: These cholesterol-lowering medications, such as fenofibrate, can also increase the risk of hypoglycemia when taken with Semi-Amaryl Tablet.

Drug-Food Interactions

Drug-Disease Interactions

Semi-Amaryl Tablet interacts with the following diseases:

G6PD Deficiency: Individuals with this genetic disorder might be at risk of hemolytic anemia when taking Semi-Amaryl Tablet.
Renal Impairment: People with kidney problems need to be cautious when using Semi-Amaryl Tablet, as it could intensify their condition.
Hepatic Impairment: Patients with liver disease should exercise caution when taking Semi-Amaryl Tablet because it could worsen their condition.

Daily Dose

The daily dose of Semi-Amaryl Tablet should be taken as prescribed by your doctor. The dosage may vary based on factors such as the severity of your condition and your response to the medicine. It's crucial to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

Overdosing on Semi-Amaryl Tablet can lead to increased side effects such as headache, nausea, and dizziness. If you believe you've taken more than the recommended amount, inform your doctor promptly.

Missed Dose

If you forget to take Semi-Amaryl Tablet at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Never increase your dosage without consulting your doctor.

Store at room temperature, ideally between 25°C.
Protect from light and moisture to maintain its effectiveness.
Always keep out of reach of children for safety reasons.
Be sure to take the medicine before its expiry date for optimal results.

Maintain a balanced diet with controlled carbohydrate intake. This helps manage your blood sugar levels, making Semi-Amaryl Tablet more effective in managing type 2 diabetes.
Regular physical activity is crucial. Aim for at least 30 minutes of moderate exercise like brisk walking daily. Exercise helps to enhance insulin sensitivity and control blood glucose levels.

Fact Box

Drug Category	Sulfonylureas
Therapeutic Category	Anti-Diabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is the main purpose of Semi-Amaryl Tablet?

Semi-Amaryl Tablet is used to manage type 2 diabetes in adults when diet and exercise alone cannot sufficiently control blood sugar levels.

How does Semi-Amaryl Tablet work in the body?

The active ingredient, glimepiride, stimulates the pancreas to release more insulin, thereby helping to lower blood sugar levels.

Can I take Semi-Amaryl Tablet with other anti-diabetic medicines?

Yes, as per your doctor's prescription, Semi-Amaryl Tablet can be taken with other anti-diabetic medications. Regular blood glucose monitoring is essential.

What should I do if I forget to take a dose of Semi-Amaryl Tablet?

If you miss a dose, take it as soon as you remember. If it's nearly time for your next dose, skip the missed dose. Don't double up.

How long will it take for Semi-Amaryl Tablet to start working?

The medicine starts lowering blood sugar within 2-3 hours of taking it orally, but full effects on blood sugar control may take several days to weeks.

Is it safe to drink alcohol while taking Semi-Amaryl Tablet?

No, it is recommended to avoid alcohol as it can increase the risk of low blood sugar (hypoglycaemia) and cause reactions like flushing, nausea and giddiness.

Are there any side effects associated with Semi-Amaryl Tablet?

Common side effects include hypoglycemia (low blood sugar), headache, nausea and dizziness. Consult your doctor if these persist or become severe.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222
DailyMed - GLIMEPIRIDE- glimepiride tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=60e9397e-83b9-489e-9683-6f87e458bbaa
Glimepiride: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696016.html
PubChem. (n.d.). Glimepiride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Glimepiride

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