Paraxin 500 Mg Capsule 10

Paraxin 500 Capsule 10

Abbott Healthcare Pvt. Ltd

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Composition

Chloramphenicol (500 Mg)

Strength:

500 MG 250 MG

Paraxin 500 mg capsule is an antibiotic medication that treats various bacterial infections. Paraxin 500 mg capsules are commonly prescribed for treating serious infections such as typhoid fever and bacterial meningitis.

Paraxin 500 mg capsule can cross the blood-brain barrier. This makes it an effective treatment for bacterial meningitis, a potentially life-threatening infection of the layers around the brain and spinal cord.

When prescribing Paraxin 500 mg capsule, healthcare providers must carefully consider the patient's medical history and current medications and regularly monitor their blood cell counts during treatment.

However, due to the potential for serious side effects, it must be carefully monitored and only prescribed in cases where other antibiotics are not effective or appropriate. Please consult your healthcare provider if you have any concerns about Chloramphenicol or your medication regimen.

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Here are the primary uses of Paraxin 500 mg capsule:

Typhoid fever: Typhoid fever, a systemic infection caused by Salmonella typhi, is similarly treated with Paraxin 500 mg capsule. It has been demonstrated to be beneficial in lowering fever duration and enhancing other disease-related symptoms.
Bacterial Meningitis: Paraxin 500 mg capsule effectively treats bacterial meningitis, a severe infection of the lining surrounding the brain and spinal cord. It can penetrate the blood-brain barrier and reach therapeutic quantities in cerebrospinal fluid, making it a viable treatment option for bacterial meningitis.
Respiratory tract infections: Paraxin 500 mg capsule is sometimes used to treat respiratory tract infections, such as pneumonia and bronchitis. It may be used as an alternative when other antibiotics are not effective or appropriate.
Skin and soft tissue infections: Paraxin 500 mg capsule can also treat skin and soft tissue infections, like cellulitis and infected wounds.
Ear infections: Paraxin 500 mg capsule can be used to treat acute otitis media (middle ear infection) caused by a range of bacteria like Haemophilus influenzae.
Urinary tract infections (UTIs): Paraxin 500 mg capsule effectively treats UTIs caused by gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae.

Directions for Use of Paraxin 500 Capsule 10

Paraxin 500 mg capsule should be swallowed and not crushed or chewed.
Paraxin 500 mg capsule can be taken with food.
Follow your doctor's instructions for taking Paraxin 500 mg capsules, including the treatment dosage, frequency, and duration.

Paraxin 500 mg capsule can be taken orally. The medication is taken by mouth with water or as directed by your doctor.

The following are the side effects of Paraxin 500 mg capsule:

Nausea: Nausea is a typical side effect of Paraxin 500 mg capsule. It is a feeling of discomfort in the stomach that may be accompanied by an urge to vomit.
Vomiting: Vomiting is a common side effect of Paraxin 500 mg capsule. It is forcefully expelling the stomach's contents through the mouth.
Diarrhoea: Paraxin 500 mg capsule may cause diarrhoea, a common side effect. It is characterised by loose, watery stools that occur more frequently than usual.
Abdominal pain: Abdominal pain is a common side effect of Paraxin 500 mg capsule. It is a pain or discomfort in the area between the chest and the pelvis.
Headache: Headache is a frequent side effect of Paraxin 500 mg capsule. It is a pain or discomfort in the head that may accompany other symptoms such as nausea, vomiting, photophobia and increased sensitivity to sound.
Dizziness: Dizziness is a typical side effect of Paraxin 500 mg capsule. It is a feeling of lightheadedness or unsteadiness that may accompany other symptoms, such as nausea and sweating.

Managing the Side Effects:

Here are some common management strategies for different side effects:

Diarrhoea: Probiotics are helpful bacteria that help restore the balance of beneficial bacteria in the stomach and treat antibiotic-induced diarrhoea. You can consume probiotic-rich foods like yoghurt or take probiotic supplements.
Nausea and Vomiting: Follow simple meals. Avoid eating oily, fried or spicy foods. Take a Paraxin 500 mg capsule before or after the meal. Do not sleep right away after eating. Consult your doctor if the symptom persists.
Headache and dizziness: Drink enough water and avoid skipping meals. Take adequate rest. Try to be relaxed and stress-free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom continues. If you are experiencing dizziness, avoid activities requiring mental alertness or physical coordination until these symptoms subside.
Abdominal pain: A common side effect of Paraxin 500 mg capsule is abdominal pain that can be managed by taking the medication with food.

Paraxin 500 mg capsule consists of Chloramphenicol. It is an antibiotic that works by inhibiting the production of bacterial proteins, which are essential for the growth and survival of bacteria. It works effectively against many types of bacteria like haemophilus influenzae and neisseria meningitidis but can have serious side effects like damaging bone marrow and causing anaemia. Chloramphenicol treats severe bacterial infections, especially in the brain.

Pregnancy

It is prohibited to use Paraxin 500 mg capsule during pregnancy. The potential undesirable effects of the Paraxin 500 mg capsule can harm both the mother's and the fetus's health. Before taking Paraxin 500 mg capsule, check with your doctor if you are pregnant or planning to become pregnant.

Breastfeeding

Paraxin 500 mg capsule is not recommended for breastfeeding women because the effects on breast milk and nursing infants are unknown. Before taking Paraxin 500 mg capsule, consult your doctor.

Alcohol

Alcohol does not appear to interact with Paraxin 500 Capsule. If you have any concerns, please see a doctor.

Liver

In patients with liver problems, Paraxin 500 Capsules should be used carefully. Individuals suffering from liver illness may have trouble absorbing drugs, increasing the likelihood of undesirable side effects. Before taking Paraxin 500 Capsule, consult your doctor.

Kidney

When taking the Paraxin 500 Capsule, patients with kidney disease or issues should proceed cautiously. Before taking a Paraxin 500 Capsule, seek medical advice from your doctor.

Using Machines & Driving

It is unclear whether Paraxin 500 Capsule will impair your ability to operate machines or drive.

Allergy

Patients with a history of allergy to Chloramphenicol should avoid using Paraxin 500 Capsules.

Children

The usage of Paraxin 500 Capsule in children is not advised. If you have any concerns, please see a doctor.

Older Patients

Patients who are elderly should use Paraxin 500 Capsule cautiously. Your doctor will decide the dosage, duration, and frequency of the Paraxin 500 Capsules based on the severity of your current illness and any other medical conditions you have.

Drug-Drug Interactions

Here are some drug interactions you should be aware of when using Paraxin 500 Capsule:

Antidepressants: Paraxin 500 Capsule may increase the blood levels of tricyclic antidepressants such as amitriptyline, nortriptyline, which can lead to toxic effects.
Anti-epileptics: Paraxin 500 Capsule can decrease the effectiveness of anti-epileptic drugs, such as phenytoin or carbamazepine.
Proton-pump inhibitors: Paraxin 500 Capsule can interfere with the absorption of proton-pump inhibitors like Pantoprazole and rabeprazole, reducing their effectiveness.
Anticoagulants: Paraxin 500 Capsule can enhance the anticoagulant effect of warfarin, leading to an increased risk of bleeding.
Immunosuppressants: Paraxin 500 Capsule can increase the blood levels of immunosuppressant drugs, such as cyclosporine or tacrolimus, which can lead to toxic effects.
Chemotherapeutic drugs: Paraxin 500 Capsule can decrease the effectiveness of chemotherapeutic drugs, such as doxorubicin or cyclophosphamide.
Benzodiazepines: Paraxin 500 Capsule can increase the blood levels of benzodiazepines, such as diazepam, which can lead to toxic effects.
Azole antifungals: Paraxin 500 Capsule can increase the blood levels of azole antifungals, such as ketoconazole or fluconazole, which can lead to toxic effects.
Macrolide antibiotics: Paraxin 500 Capsule can increase the blood levels of macrolide antibiotics, such as erythromycin, which can lead to toxic effects.
Statins: Paraxin 500 Capsule can increase the blood levels of statins, such as simvastatin, which can lead to toxic effects.
Anti-arrhythmic agents: Paraxin 500 Capsule can increase the blood levels of anti-arrhythmic agents, such as amiodarone, which can lead to toxic effects.
Antivirals: Paraxin 500 Capsule can decrease the effectiveness of antiviral drugs, such as acyclovir or valacyclovir.
Phosphodiesterase type 5 (PDE5) inhibitors: Paraxin 500 Capsule can increase the blood levels of PDE5 inhibitors, such as sildenafil or tadalafil, which can lead to toxic effects.

Drug-Food Interactions

It is essential to know interactions to ensure optimal effectiveness and safety of the medication. Here are the drug-food interactions of the Paraxin 500 mg capsule.

Dairy products: Calcium in dairy products can bind to Paraxin 500 mg capsule in the gut and reduce its absorption. Therefore, avoiding consuming dairy products 2 hours before or after taking Paraxin 500 mg capsule is recommended.
Iron-rich foods: Iron supplements or iron-rich foods such as red meat, spinach, and beans can bind to Paraxin 500 mg capsule and reduce its absorption. It is advised to separate the consumption of iron-rich foods or supplements by at least 2 hours from taking Paraxin 500 mg capsule.
Alcohol: The combination of alcohol and Paraxin 500 mg capsule can cause additive effects on the central nervous system, leading to dizziness, confusion, and impaired coordination. Therefore, it is recommended to avoid alcohol consumption while taking Paraxin 500 mg capsule.

Drug-Disease Interactions

In the case of Paraxin 500 Capsule, several drug-disease interactions should be considered:

Colitis: Paraxin 500 Capsule has been associated with developing pseudomembranous colitis, a severe colon inflammation. Patients with a history of colitis should be monitored closely while taking Paraxin 500 Capsule, and any signs of diarrhoea or abdominal pain should be reported to a healthcare provider immediately.
Bone marrow suppression: Paraxin 500 Capsule can potentially suppress bone marrow function, decreasing red and white blood cell counts. Patients with pre-existing bone marrow suppression or blood disorders should be monitored closely while taking Paraxin 500 Capsule.
Liver and kidney problems: Paraxin 500 Capsule is primarily metabolised by the liver and excreted by the kidneys. Patients with liver or kidney problems may have difficulty metabolising and excreting Paraxin 500 Capsule properly, leading to an increased risk of toxicity. Dose adjustments may be necessary for these patients.

Daily Dose

The recommended daily dose of Paraxin 500 mg capsule is once daily, with food, as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is crucial to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes an excessive amount of Paraxin 500 mg capsule by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. Symptoms of an overdose include vomiting, diarrhoea, dizziness, drowsiness, stomach pain and nausea.

Missed Dose

If you forget to take a medication dosage, do so immediately. Ignore the missed dose and continue your usual dosing schedule if it is time for your next dose. Never double up on your medication to make up for a missed dosage. It is advised not to skip any antibiotic doses because doing so could cause treatment to fail.

Store Paraxin 500 mg capsule intact in the packing it has been bought.
Store the Paraxin 500 mg capsule at room temperature below 30 ºC.
Protect Paraxin 500 mg capsule from extreme light and moisture.
Keep Paraxin 500 mg capsule away from the reach of children.
Do not use Paraxin 500 mg capsule after the expiry date has passed.

Eat a diet high in lean meat, fresh produce, whole grains, pulses, and healthy fats.
Reduce your consumption of processed, high-fat foods, sugary beverages, and alcohol.
Antibiotics alter the good bacteria in the stomach, promoting digestion. As a result, probiotic-rich meals such as yoghurt/curd should be consumed.
Stay hydrated by drinking plenty of water.
Exercise regularly. Try to perform at least 30 minutes of moderate exercise on most days.
Get enough rest and sleep, ideally 7-9 hours per night.
Relaxation techniques like meditation, deep breathing, and yoga can help manage stress.
Avoid smoking and tobacco usage, and limit secondhand smoke exposure.

Do not skip any doses and complete the treatment, even if you feel better. If you stop it too soon, the infection may resurface and be more challenging to treat.
Before starting therapy and regularly, your doctor may order blood tests to examine your blood cells.
If your symptoms persist after a few days, consult your doctor.
Taking Paraxin 500 mg capsule with food or immediately after a meal is recommended. This helps in better absorption of the medication and reduces the chances of gastrointestinal side effects like nausea, vomiting, diarrhoea, and stomach pain.

Fact Box

Drug Category	Nitrobenzene derivative
Therapeutic Category	Antibiotics
Available Dosage Types	Capsule, Eye Drops, Eye Ointment, Injection, Suspension, Aplicap
Habit Forming	No
Ailment	Typhoid fever, Severe bacterial infections

How many times a day should I use Paraxin 500 mg capsule?

The recommended dosage and frequency of use for the Paraxin 500 mg capsule will depend on the specific infection being treated and other factors like age and overall health. However, following the specific dosing instructions your doctor provides is crucial.

Is Paraxin 500 mg capsule a painkiller?

No, Paraxinl 500 mg capsule is not a painkiller. It is an antibiotic that treats bacterial infections.

Is Paraxin 500 an antibiotic?

Yes, Paraxinl 500 mg capsule is an antibiotic that treats various bacterial infections. Paraxin 500 mg capsule is effective against many gram-positive and gram-negative bacteria, making it a broad-spectrum antibiotic.

Last Updated On 15 Feb. 2024 | 12:50PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

https://wa.kaiserpermanente.org/kbase/topic.jhtml?docId=hn-10000779
KD. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723 & 724.
https://www.fdaghana.gov.gh/img/pils/Chloramphenicol%20250mg%20Capsule%20(Chloramphenicol).pdf
https://pubchem.ncbi.nlm.nih.gov/compound/Chloramphenicol%3E

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