Neptaz 50 Mg Tablet 14

Neptaz 50mg Tablet 14

Mankind Pharmaceuticals Ltd.

Strip of 14 Units

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MRP ~~₹320.6~~

₹262.89

₹22.90/Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Neptaz 50mg Tablet is a prescription medication primarily used for managing chronic heart failure. This medication belongs to a class of medicines known as angiotensin receptor neprilysin inhibitors (ARNI).

In addition to managing chronic heart failure, this medicine can help to reduce related symptoms and improve energy levels, enhancing the overall well-being of patients.

Before you start taking this medicine, it is crucial that you consult your doctor about the appropriate dosage and frequency. Inform your doctor about any pre-existing medical conditions or ongoing medications you are taking. If any side effects occur while on this medicine, notify your doctor immediately. Remember to continue taking the medication for the duration prescribed by your doctor for optimal results.

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Neptaz 50mg Tablet is used for the following:

Relief of chronic heart failure symptoms
Improvement in energy levels
Enhancement of overall well-being in chronic heart failure patients

Directions for Use of Neptaz 50mg Tablet 14

Follow these instructions while taking Neptaz 50mg Tablet:

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
You can take this medicine with or without food.
Take your tablet at the same time each day to ensure optimal effects.
Continue to take even if you start to feel better. It's important not to stop taking this medicine without speaking to your doctor first.
If you're uncertain about how to use this medicine, please consult your doctor for specific advice.

Neptaz 50mg Tablet is taken orally.

Neptaz 50mg Tablet may have the following common side effects:

Angioedema (swelling in deeper layers of your skin)
Hypotension (low blood pressure)
Impaired renal function
Hyperkalemia (high levels of potassium in your blood)

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Neptaz 50mg Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Neptaz 50mg Tablet contains two active ingredients which work together to manage chronic heart failure:

Sacubitril (24 mg): This component acts as a neprilysin inhibitor. Neprilysin is an enzyme that breaks down certain substances in the body that cause blood vessels to tighten. By inhibiting neprilysin, sacubitril helps relax and widen blood vessels, reducing blood pressure and making it easier for the heart to pump blood.
Valsartan (26 mg): Valsartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by blocking the action of a substance in your body called angiotensin II, which causes blood vessels to constrict or tighten. By blocking this action, valsartan helps relax and widen blood vessels, thereby reducing blood pressure.
Together, these two components help manage chronic heart failure by reducing blood pressure and easing the workload on the heart.

Pregnancy

Neptaz 50mg Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Neptaz 50mg Tablet is contraindicated for breastfeeding women. It is best to consult your doctor to understand the potential risks and benefits.

Alcohol

It is best to limit your alcohol consumption while taking Neptaz 50mg Tablet.

Liver

If you have a history of liver disease, caution is advised while taking Neptaz 50mg Tablet. It's always wise to discuss any liver-related concerns with your doctor before starting this medicine.

Kidney

Caution is advised when using Neptaz 50mg Tablet, particularly if you have a history of kidney diseases. Consult your doctor before taking this medicine if you have any kidney problems.

Using Machines & Driving

Exercise caution while operating machinery or driving when you're on Neptaz 50mg Tablet, as it may cause dizziness due to low blood pressure. You should be careful while performing these activities until you know how the medicine affects you.

Allergy

If you are allergic to sacubitril or valsartan, the active ingredients in Neptaz 50mg Tablet, avoid taking this medicine. Consult your doctor for alternative options.

Children

Caution is advised while giving Neptaz 50mg Tablet to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Neptaz 50mg Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised especially if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Neptaz 50mg Tablet may interact with the following medicines:

Blood pressure medicines such as amlodipine or lisinopril used to manage your blood pressure, may interact with Neptaz 50mg Tablet. This could increase your risk of developing low blood pressure or hypotension.
Heart condition medicines like digoxin, for heart conditions may have their effects altered when taken with Neptaz 50mg Tablet. This could potentially lead to an increased risk of side effects.
Potassium supplements alongside this tablet might boost your blood potassium levels (hyperkalemia).
Kidney function medicines for kidney function like furosemide or spironolactone could interact with this medication.

Drug-Food Interactions

Certain foods might interact with Neptaz 50mg Tablet, specifically:

High-Potassium Foods: Eating foods rich in potassium (like bananas or broccoli) while taking Neptaz 50mg Tablet can increase your risk of hyperkalemia.

Drug-Disease Interactions

Neptaz 50mg Tablet may interact with the following diseases:

Kidney Disease: If you have kidney disease, you should exercise caution when taking Neptaz 50mg Tablet as it could potentially exacerbate your condition.
Liver Disease: Patients with liver disease need to be careful as this medication might worsen their condition.
Hyperkalemia: As Neptaz 50mg Tablet might increase potassium levels in the blood, patients already suffering from hyperkalemia should be cautious while using this medicine.

Daily Dose

Your doctor will prescribe the daily dose of t. This dosage could vary based on factors like disease severity and your response to the medicine. Always follow your doctor's instructions regarding dosage.

Over Dose

In case of an overdose of Neptaz 50mg Tablet, you might feel dizzy due to low blood pressure or encounter swelling of the face, lips, tongue, or throat. If symptoms persist, consult your doctor.

Missed Dose

If you forget to take Neptaz 50mg Tablet, take it as soon as you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule.

Store Neptaz 50mg Tablet in the original package to protect it from moisture.
Keep it at a temperature not exceeding 30°C.
Avoid exposing the medication to direct light or air.
Ensure it's out of sight and reach of children.
Always check the expiry date before use and do not use if expired.

Adopt a balanced, low-sodium diet: Excessive salt can exacerbate heart failure symptoms, so try to limit your intake.
Engage in regular physical activity as tolerated: It's essential for managing chronic heart failure. However, avoid overexertion and always follow your doctor's advice on suitable exercises.

Fact Box

Drug Category	Heart failure management
Therapeutic Category	Cardiovascular
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic heart failure

What is Neptaz 50mg Tablet used for?

This medication is prescribed for managing chronic heart failure, helping to reduce symptoms and increase energy levels.

How should Neptaz 50mg Tablet be taken?

You should take this tablet orally, as directed by your doctor, with or without food, at the same time each day.

Are there any side effects of Neptaz 50mg Tablet?

Side effects may include swelling of face or throat, low blood pressure, impaired kidney function, and high potassium levels in blood.

Can pregnant women take Neptaz 50mg Tablet?

No, Neptaz 50 mg Tablet is contraindicated for pregnant women. It's also not recommended during breastfeeding.

What precautions should I take while using Neptaz 50mg Tablet?

Inform your doctor about any pre-existing medical conditions, especially kidney or liver disease, and all current medications before starting treatment.

What if I miss a dose of Neptaz 50mg Tablet?

If you miss a dose of this medication, consult your doctor for guidance on how to manage the missed dose.

How should I store Neptaz 50mg Tablet?

Store the tablets below 30°C in its original package to protect from moisture.

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer & Editor | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Osama Ahmed

Dental/Medical Writer, Editor, Reviewer | 2 years

Bachelor of Dental Surgery

Check out Editorial Policy

References

Morrow, D. A., & Velazquez, E. J. (2016). The New England Journal of Medicine: Angiotensin–Neprilysin Inhibition in Heart Failure. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750837/
U.S. Food and Drug Administration. (2019). ENTRESTO (sacubitril and valsartan) Tablets, for Oral Use. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
U.S. Food and Drug Administration. (n.d.). FDA Drug Approval Package: Valsartan (Diovan) NDA #020665. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021283s033lbl.pdf
National Library of Medicine (US). (n.d.). DailyMed - ENTRESTO- sacubitril and valsartan tablet, film coated. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9402b022-5809-4251-dfef-54f6ef5723fe
Nicolas, D., Kerndt, C. C., & Reed, M. (2022, May 26). Sacubitril-Valsartan. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK507904/

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