Mesacol Cr 1 Gm Granules 1

Mesacol Cr 1g Granules 1

Sun Pharma Laboratories Ltd.

Sachet of 1 GM

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Composition

Mesalazine (1000 Mg)

Strength:

2000 MG 1000 MG

Mesacol CR 1g Granules are primarily used to manage inflammatory bowel diseases, specifically ulcerative colitis and Crohn's disease. This medicine falls under the category of aminosalicylates, which are known for their anti-inflammatory properties.

In addition to managing ulcerative colitis and Crohn's disease, these granules are also used to maintain remission of these conditions. They help reduce inflammation in the intestinal tract and promote healing, thereby helping to control the symptoms of these diseases.

Before you start taking this medicine, it's important to consult your doctor who will guide you on the right dosage and frequency. Inform your doctor about any ongoing medications or existing health conditions. If you encounter any side effects while taking this medicine, notify your doctor immediately. It's essential to continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Mesacol CR 1g Granules are used in the management of the following conditions:

Bringing relief to adults with active, mild to moderate ulcerative colitis.
Helping maintain a state of remission in cases of ulcerative colitis.
Assisting in handling mildly to moderately active Crohn's disease.
Ensuring the maintenance of the remission phase in patients with Crohn's disease.

Directions for Use of Mesacol Cr 1g Granules 1

Using Mesacol CR 1g Granules involves a few simple steps:

Start by pouring the granules from the sachet onto your tongue.
Ensure you do not chew the granules.
Swallow them down with a glass of water or orange juice.
Always remember to follow your doctor's advice on using this medication correctly.

Mesacol CR 1g Granules is taken orally.

Side Effects of Mesacol Cr 1g Granules 1

Mesacol CR 1g Granules can cause a few side effects, which are usually mild and temporary. Here are some common ones:

Headache
Nausea
Diarrhoea
Abdominal pain
Rash
Flatulence: This refers to excessive gas in the stomach or intestines.
Dyspepsia: Also known as indigestion, this can lead to discomfort in the upper abdomen.

Remember, it's essential to monitor how your body reacts after taking this medication.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Mesacol CR 1g Granules. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips for managing common side effects:

Diarrhoea: Try taking Mesacol CR 1g Granules with food to lessen its impact on your stomach.
Dyspepsia: If you're dealing with indigestion, consider consuming this medicine after meals.

Mesacol CR 1g Granules contain mesalazine (1000 mg), which works in several ways:

Inflammatory Mediator Inhibition: Mesalazine helps inhibit the production of pro-inflammatory mediators like prostaglandins and leukotrienes that contribute to inflammation.
Free Radical Scavenging: The medicine scavenges free radicals and reactive oxygen species that contribute to oxidative stress and tissue damage in the intestines.
Immune Cell Regulation: Mesalazine prevents the activation and proliferation of inflammatory immune cells, helping to reduce inflammation.

By acting through these mechanisms, mesalazine helps manage inflammation in inflammatory bowel diseases and maintain remission of these conditions

Pregnancy

Mesacol CR 1g Granules is not recommended during pregnancy unless the benefits outweigh the risks. If you're pregnant or planning to conceive, it's best to discuss this with your doctor before starting this medicine.

Breastfeeding

Small amounts of the active ingredient, mesalazine, are excreted in breast milk. You should consult your doctor to understand the potential risks and benefits before using Mesacol CR 1g Granules while breastfeeding.

Alcohol

Occasional alcohol consumption is unlikely to affect the efficacy or safety of mesalazine. However, alcohol can irritate the digestive tract and may worsen symptoms of inflammatory bowel disease.

Liver

Caution is advised when taking Mesacol CR 1g Granules if you have mild to moderate liver impairment. It's not recommended for those with severe liver diseases. Ensure you discuss any liver health issues with your doctor before starting this medicine.

Kidney

Mesacol CR 1g Granules should be used with caution if you have a history of kidney problems. It's advisable to consult your doctor before taking this medicine.

Using Machines & Driving

There is no known effect of Mesacol CR 1g Granules on your ability to drive or operate machines. However, if you experience side effects such as dizziness or blurred vision, avoid these activities until you feel well again.

Allergy

This medicine is contraindicated if you have a known hypersensitivity to salicylates or any other component of the formulation. If you're aware of any allergies, ensure to discuss them with your doctor before starting this medication.

Children

Mesacol CR 1g Granules is meant for adult use. Caution is advised while giving this medicine to children under 12 years old. Always consult a doctor before giving any medicine to a child.

Older Patients

Elderly patients should take Mesacol CR 1g Granules under medical supervision, as they may be more susceptible to its side effects. If you're above 70 or have liver and kidney health concerns, it's best to consult your doctor who will guide you based on your overall health status.

Interactions of Mesacol Cr 1g Granules 1

Drug-Drug Interactions

Mesacol CR 1g Granules interacts with the following medicines:

Azathioprine or 6-Mercaptopurine: These medicines, when taken with Mesacol CR 1g Granules, increase the risk of blood disorders.
Coumarin-Type Anticoagulants: Medicines like warfarin may have an increased anticoagulant effect when taken with this medication.
Probenecid and Sulfinpyrazone: These medicines can decrease the excretion of mesalazine from the body.
Antacids or Adsorbents: The absorption of mesalazine can be reduced if you take antacids or adsorbents.

Drug-Food Interactions

There are no specific foods known to interact with Mesacol CR 1g Granules.

Drug-Disease Interactions

Mesacol CR 1g Granules interacts with the following diseases:

Severe Liver Impairment: This medicine should not be taken if you have severe liver impairment as it could worsen your condition.
Severe Kidney Impairment: If you have severe kidney impairment, avoid taking this medicine as it could worsen your condition.

Daily Dose

Your prescribed daily dose of Mesacol CR 1g Granules should be strictly followed. This dosage may vary depending on individual factors such as the severity of your condition and your response to the medicine. Always adhere to your doctor's instructions and avoid exceeding the prescribed dosage without consulting your doctor.

Over Dose

If you accidentally take more than the recommended amount of Mesacol CR 1g Granules, you may experience symptoms like nausea, abdominal pain, and bloody diarrhoea. In such a situation, it is advisable to inform your doctor.

Missed Dose

In case you forget to take a dose of Mesacol CR 1g Granules, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage to compensate for a missed dose without discussing with your doctor.

Store Mesacol CR 1g Granules below 30°C in a dry place.
Avoid locations with high heat and direct sunlight.
Keep the granules in their original packaging until use, to protect from moisture.
Ensure the medicine is out of reach of children.
Always check the expiry date and use before this point.

To support your inflammatory bowel disease management plan, consider incorporating a high-fibre diet. Fibre helps reduce inflammation in the colon.
Regular exercise can improve your overall health and potentially lessen symptoms. A gentle walk or yoga session might be beneficial. Always consult your doctor before starting any new activity.

Fact Box

Drug Category	Anti-Inflammatory
Therapeutic Category	Aminosalicylates
Available Dosage Types	Granules
Habit Forming	No
Ailment	Ulcerative Colitis, Crohn's Disease

What is Mesacol CR 1g Granules used for?

It's used to manage inflammatory bowel diseases like ulcerative colitis and Crohn's disease by reducing inflammation in the colon.

How should I take Mesacol CR 1g Granules?

Place the granules on your tongue and wash down with water or orange juice, without chewing. Always follow your doctor's instructions.

Can I stop taking Mesacol CR 1g Granules if my symptoms improve?

No, continue taking your medicine as prescribed. Stopping may increase the risk of disease relapse. Consult your doctor for advice.

Can I take pain relievers like ibuprofen while on this medicine?

NSAIDs may increase disease relapse risk and gastrointestinal ulceration. Consult your doctor before using over-the-counter medicines.

Is it safe to consume alcohol while taking this medicine?

Occasional alcohol consumption shouldn't affect its efficacy or safety, but alcohol may worsen inflammatory bowel disease symptoms. Consult your doctor for advice.

How long does it take for Mesacol CR 1g Granules to work?

Symptom improvement is usually noted within 3-21 days, but it can take up to 6 weeks for complete remission.

What should I do if I accidentally overdose on Mesacol CR 1g Granules?

If you ingest more than the prescribed amount, seek emergency medical attention immediately due to potential abdominal discomfort and diarrhoea.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

References

U.S. Food and Drug Administration. (2020). Mesalamine Label. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020406s092,021428s039lbl.pdf
Mesalazine. (n.d.). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB00244
Mesalazine: A medicine that treats inflammatory bowel conditions including ulcerative colitis and Crohn's disease. (2021, 21). nhs.uk. https://www.nhs.uk/medicines/mesalazine
Mesalamine: MedlinePlus drug information. (n.d.). MedlinePlus Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a688021.html

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