Megazid Xp 1000125 Mg Injection 1

Megazid Xp 1g/125mg Injection 1

Mapra Laboratories Pvt. Ltd

Vial of 1 Units

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MRP ~~₹310~~

₹254.2

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Composition

Ceftazidime (1000 Mg) + Tazobactam (125 Mg)

Megazid Xp 1g/125mg Injection 1 is chiefly used for managing serious bacterial infections in different parts of the body. This combination medicine belongs to the category of antibiotics.

This medicine is also used in the management of several other infections when caused by susceptible bacteria. These include Lower Respiratory Tract Infections (LRTI), Urinary Tract Infections (UTI), Skin and Skin Structure Infections (SSSI), Bacterial Septicemia, Bone and Joint Infections, Intra-abdominal Infections, Pelvic Inflammatory Disease (PID), Bacterial Meningitis, and for Surgical Prophylaxis.

Before using this medicine, you must consult your doctor for the proper dosage and frequency. Be sure to inform your doctor about any pre-existing conditions or ongoing medications. If you experience side effects while using this medicine, immediately notify your doctor. Remember, it is essential to continue using the medicine for the entire duration your doctor prescribes for optimal results.

Megazid Xp 1g/125mg Injection 1 is used for managing these health conditions:

Lower Respiratory Tract Infections, including those acquired in hospitals.
Urinary Tract Infections, particularly pyelonephritis.
Skin and Skin Structure Infections.
Bacterial Septicemia.
Bone and Joint Infections.
Intra-abdominal infections such as peritonitis, gallbladder, and biliary tract infections.
Pelvic Inflammatory Disease.
Bacterial Meningitis.
For preventive measures during surgeries.

Directions for Use of Megazid Xp 1g/125mg Injection 1

It is administered through an intravenous infusion only.
The injection should be reconstituted with a suitable solvent before administering.
The prepared solution should be diluted with a compatible intravenous solution before infusion.

Megazid Xp 1g/125mg Injection 1 is administered intravenously.

Side Effects of Megazid Xp 1g/125mg Injection 1

Here are some common side effects you might experience while using Megazid Xp 1g/125mg Injection 1:

Nausea and vomiting
Diarrhoea
Stomach pain
Headache
Dizziness
Rash and itching: This can involve red, bumpy, scaly or itchy patches on your skin.
Pain at the injection site: You may experience discomfort or soreness where the injection was given.
Increased liver enzymes: This might show up in blood tests as a sign of possible liver damage.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Megazid Xp 1g/125mg Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Nausea and vomiting: To lessen these effects, get the Megazid Xp 1g/125mg Injection 1 after meals.
Diarrhoea: Stay hydrated by drinking plenty of fluids. If this doesn't help, consult your doctor.

How Megazid Xp 1g/125mg Injection 1 Works?

Megazid Xp 1g/125mg Injection 1 contains two active ingredients:

Cefotaxime Sodium equivalent to Cefotaxime (1000 mg): As a third-generation cephalosporin antibiotic, cefotaxime works by binding to and inactivating penicillin-binding proteins (PBPs) in bacterial cells. These PBPs are crucial in forming the peptidoglycan layer of bacterial cell walls. By disrupting this synthesis process, cefotaxime inhibits cell wall assembly and causes cell lysis or destruction.
Tazobactam Sodium equivalent to Tazobactam (125 mg): This component acts as a beta-lactamase inhibitor. Beta-lactamase enzymes produced by resistant bacteria can degrade cefotaxime. Tazobactam protects cefotaxime from this degradation, effectively extending the antibiotic spectrum of cefotaxime to include many beta-lactamase-producing bacteria that could otherwise resist cefotaxime.

Pregnancy

Caution is advised while taking Megazid Xp 1g/125mg Injection 1 if you are pregnant. It is best to consult your doctor before starting this medicine.

Breastfeeding

If breastfeeding, caution is advised when administering Megazid Xp 1g/125mg Injection 1. It is wise to discuss this with your doctor beforehand.

Alcohol

Avoid consuming alcohol during the course of Megazid Xp 1g/125mg Injection 1 as it may worsen side effects.

Liver

If you have a history of liver problems, it is recommended that you discuss them with your doctor before starting Megazid Xp 1g/125mg Injection 1. This medicine can affect liver function.

Kidney

If you have any kidney health issues, consult your doctor before using Megazid Xp 1g/125mg Injection 1.

Using Machines & Driving

Megazid Xp 1g/125mg Injection 1 may cause dizziness or fatigue. Be cautious while driving or operating machinery until you know how this medicine affects you.

Allergy

If you're allergic to cefotaxime, tazobactam or any other cephalosporin or penicillin antibiotics, avoid using Megazid Xp 1g/125mg Injection 1. Consult your doctor for alternatives.

Children

Megazid Xp 1g/125mg Injection 1 is not recommended for children under 18. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Megazid Xp 1g/125mg Injection 1 under medical supervision as they may be more susceptible to its side effects. Caution is advised, particularly for those above 70 who might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Interactions of Megazid Xp 1g/125mg Injection 1

Drug-Drug Interactions

Megazid Xp 1g/125mg Injection 1 interacts with the following medicines:

Aminoglycoside Antibiotics: If you take antibiotics such as gentamicin or amikacin, Megazid Xp 1g/125mg Injection 1 may interact with these, potentially changing their effects.
Diuretics: Medicines like furosemide and bumetanide can affect how Megazid Xp 1g/125mg Injection 1 works in your body.
Anticoagulants: The effectiveness of anticoagulants such as warfarin and heparin may be altered when taken with Megazid Xp 1g/125mg Injection 1.
Antigout medicines: Medications like probenecid can interact with Megazid Xp 1g/125mg Injection 1, possibly leading to increased levels of cefotaxime and tazobactam in your body.
Live Bacterial Vaccines: Using live vaccines while you are on Megazid Xp 1g/125mg Injection 1 may decrease their effectiveness.

Drug-Food Interactions

No specific food interactions are known with Megazid Xp 1g/125mg Injection 1.

Drug-Disease Interactions

Megazid Xp 1g/125mg Injection 1 interacts with the following diseases:

Liver Disease: If you have liver disease, using Megazid Xp 1g/125mg Injection 1 might cause complications since this medicine is metabolised in the liver.
Kidney Impairment: People with kidney problems should be cautious as this medication is excreted through the kidneys and could worsen their condition.
Gastrointestinal Diseases: If you have a history of gastrointestinal issues, especially colitis, care should be taken when using this medicine as it may exacerbate certain symptoms.

Dosage of Megazid Xp 1g/125mg Injection 1

Daily Dose

Your doctor will prescribe the appropriate daily dose of Megazid Xp 1g/125mg Injection 1. This will depend on factors such as the severity of your condition and your response to the medicine. It's crucial to adhere to your doctor's instructions and never change your dose without consulting them first.

Over Dose

If you accidentally administer more than the prescribed dose of Megazid Xp 1g/125mg Injection 1, you may experience side effects like nausea, dizziness, or headache. If these symptoms persist or worsen, inform your doctor right away.

Missed Dose

If you forget to administer a dose of Megazid Xp 1g/125mg Injection 1, do so as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without consulting your doctor.

Store Megazid Xp 1g/125mg Injection 1 at a temperature below 30°C.
Protect it from light and moisture.
Keep the medicine out of reach and sight of children.
Always check the expiry date before using the injection.

If you're being administered Megazid Xp 1g/125mg Injection 1 for urinary tract infections, drink plenty of water to help flush out bacteria from your system.
For those managing skin infections, ensure cleanliness in personal hygiene practices to prevent further bacterial spread.

Fact Box

Drug Category	Cell Wall Synthesis Inhibitor
Therapeutic Category	Antibiotic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Lower Respiratory Tract Infections, Urinary Tract Infections, Bacterial Septicemia

What is Megazid Xp 1g/125mg Injection 1 used for?

It's used to manage serious bacterial infections in various parts of the body, like the lungs, urinary tract, skin, and bones.

How does Megazid Xp 1g/125mg Injection 1 work?

It works by stopping the growth and spread of bacteria. One of its ingredients disrupts bacterial cell walls while the other protects it from degradation.

Can I drink alcohol while using Megazid Xp 1g/125mg Injection 1?

It is advisable to avoid alcohol during treatment. Alcohol may interfere with the effectiveness of this medicine.

How soon will I feel better after starting Megazid Xp 1g/125mg Injection 1?

You should start feeling better within a few days. However, it's crucial to complete the full course as your doctor prescribes.

Can I use Megazid Xp 1g/125mg Injection 1 if I am breastfeeding?

If you are breastfeeding, discuss with your doctor before starting this medication. It's important to weigh the benefits against potential risks.

Are there any side effects of Megazid Xp 1g/125mg Injection 1?

Yes, some common side effects include nausea, headache, skin rash, and discomfort at the injection site. If these persist or worsen, consult your doctor.

What precautions should I take while using Megazid Xp 1g/125mg Injection 1?

Inform your doctor if you have any allergies or pre-existing conditions, such as kidney or liver problems. Always follow your doctor's advice on its use.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

References

Cefotaxime Injection. (n.d.). Medlineplus.Gov. Retrieved August 27, 2024, from https://medlineplus.gov/druginfo/meds/a682765.html
Cefotaxime. (2024, July 26). https://go.drugbank.com/drugs/DB00493
Cefotaxime - StatPearls - NCBI bookshelf. (2023, July 10). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK560653/
Tazobactam. (2022, September 15). DrugBank Online | Database for Drug and Drug Target Info. https://go.drugbank.com/drugs/DB01606

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