Lodoz 25625 Mg Tablet 10

Lodoz 2.5 Tablet 10

Merck Ltd

Strip of 10 Units

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Composition

Bisoprolol (2.5 Mg) + Hydrochlorothiazide (6.25 Mg)

Strength:

2.5 MG

Lodoz 2.5 Tablet is used to manage hypertension or high blood pressure, which can cause serious health complications if left unchecked. This medicine is a combination of two active ingredients, belonging to the cardioselective beta-blockers and thiazide diuretics categories.

It is also indicated for patients whose blood pressure isn't adequately controlled with just one medication. It can be part of an effective treatment plan if you require more than one medication type to manage hypertension.

Before starting this tablet, consult your doctor for advice on appropriate dosage and frequency. Inform your doctor of pre-existing medical conditions or medications you are taking. If you experience side effects while using this medicine, promptly inform your doctor. Take the medicine for the duration prescribed by your doctor for optimal results.

Lodoz 2.5 Tablet is used for the following:

Managing high blood pressure
Controlling hypertension where a single medicine isn't effective
Initial therapy for patients likely to need multiple blood pressure medicines

Directions for Use of Lodoz 2.5 Tablet 10

Using Lodoz 2.5 Tablet is simple. Here are the steps you should follow:

Swallow whole tablet with water.
Do not crush or chew the tablet.
Take daily, with or without food, as advised by the doctor.
Always follow the dosage directed by your doctor.
For queries or concerns about this medicine, consult your doctor.

Lodoz 2.5 Tablet is taken orally.

Lodoz 2.5 Tablet may have the following common side effects:

Fatigue
Dizziness
Headache
Bradycardia: Slower-than-normal heart rate.
Hypotension: Lower-than-normal blood pressure.
Gastrointestinal disturbances such as nausea, vomiting, diarrhoea, and constipation
Hypokalaemia: Low potassium levels in blood.
Hyperuricemia: Characterised by high uric acid levels in blood, which could potentially lead to gout.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lodoz 2.5 Tablet. However, if you experience serious side effects or worsening of symptoms, consult your doctor.

Here are some general guidelines for managing common side effects:

Fatigue: If you feel tired after taking this medicine, consider taking it at night so the fatigue does not interfere with your daily routine.
Gastrointestinal disturbances: If you experience nausea or upset stomach, take the tablet with a meal.

Lodoz 2.5 Tablet contains two active ingredients:

Bisoprolol (2.5 mg): This is a selective beta1-adrenergic receptor blocker that reduces workload on your heart and blood vessels. It slows your heart rate and decreases the force with which your heart muscle contracts, lowering blood pressure. Bisoprolol reduces your body's production of renin, an enzyme involved in regulating blood pressure.
Hydrochlorothiazide (6.25 mg): A diuretic, hydrochlorothiazide works by increasing the excretion of sodium, chloride, and water from your kidneys. It reduces blood volume and lowers blood pressure. Hydrochlorothiazide relaxes smooth muscles in blood vessels, adding to its antihypertensive effect.

Pregnancy

It's not advisable to take Lodoz 2.5 Tablet during pregnancy as it may harm the foetus. If pregnant, consult your doctor prior to taking this medicine.

Breastfeeding

Lodoz 2.5 Tablet is not recommended while breastfeeding as it is uncertain if its ingredients pass into breast milk. Before taking this medicine, discuss potential risks and benefits with your doctor.

Alcohol

Caution is advised in consuming alcohol while taking Lodoz 2.5 Tablet as it may increase dizziness and light-headedness. Consult your doctor for advice on alcohol consumption while on this medication.

Liver

Lodoz 2.5 Tablet should not be used if you have severe liver disease or a history of liver problems. Consult your doctor before starting this medication.

Kidney

If you have serious kidney problems or kidney disease, Lodoz 2.5 Tablet shouldn't be taken. Consult your doctor before starting this medicine.

Using Machines & Driving

Taking Lodoz 2.5 Tablet may cause dizziness or tiredness, which could affect your ability to drive or operate machinery safely. If this happens, avoid these activities and consult your doctor.

Allergy

Don't take Lodoz 2.5 Tablet if you're allergic to bisoprolol, hydrochlorothiazide, or any other ingredient in the tablet. Inform your doctor about your allergies.

Children

Lodoz 2.5 Tablet is intended for adults; it's not advisable to give it to children without consulting a doctor.

Older Patients

Older patients may be more susceptible to the side effects of Lodoz 2.5 Tablet and may have age-related kidney or liver issues. If you're above 70 years of age, take this medicine under your doctor's supervision.

Drug-Drug Interactions

Lodoz 2.5 Tablet interacts with the following medicines:

Antihypertensive agents: Medicines like amlodipine or lisinopril may enhance the blood pressure-lowering effect of this medicine, increasing the risk of low blood pressure or hypotension.
Insulin and oral antidiabetic agents: When taken alongside this tablet, these medications can cause your blood sugar to drop too low, leading to hypoglycaemia.
Non-steroidal anti-inflammatory medications: Medicines like ibuprofen and naproxen can lessen the effectiveness of this tablet in lowering blood pressure and can potentially cause acute kidney failure.
Lithium: If you are taking lithium for mental health conditions, combining it with this medicine may increase lithium levels in your body, causing lithium toxicity.

Drug-Food Interactions

There are no specific food interactions known with Lodoz 2.5 Tablet. However, it is always best to take this medicine as recommended by your doctor.

Drug-Disease Interactions

Lodoz 2.5 Tablet interacts with the following diseases:

Heart failure: Patients suffering from heart failure should use caution when taking this medicine as it can worsen their condition.
Diabetes: This medication can affect blood sugar control, requiring closer monitoring of glucose levels.
Gout: This tablet may lead to increased uric acid levels, which could trigger a gout attack in susceptible patients.
Kidney disease: This medicine might not work as well if your kidneys aren't functioning properly. If you have severe kidney disease, you should not use this tablet.
Liver disease: If you have severe liver disease, this tablet may not be suitable for you as it might worsen your condition.

Daily Dose

Take Lodoz 2.5 Tablet daily as directed by your doctor. Your dosage may vary depending on your condition's severity and response to treatment. Never change the dosage without consulting your doctor.

Over Dose

If you accidentally take more than the prescribed dose of Lodoz 2.5 Tablet, you might experience severe dizziness or a slow heartbeat. Inform your doctor if this happens.

Missed Dose

If you forget to take your usual dose of Lodoz 2.5 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and carry on with your regular schedule. Consult your doctor before changing your dosage.

Store Lodoz 2.5 Tablet at room temperature, ideally between 15-30°C.
Keep it in a tightly sealed container to protect from air and moisture.
Avoid exposing the medicine to direct sunlight.
Always keep this medicine out of reach of children.
Use before the expiry date mentioned on the product packaging.

Limit your intake of high-sodium foods and drinks as they can increase blood pressure.
Engage in regular physical activity, like brisk walking or cycling, as this can help lower your blood pressure. Remember to consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	Beta blocker, diuretic
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Hypertension

What is Lodoz 2.5 Tablet used for?

Lodoz 2.5 Tablet is used to manage high blood pressure in adults who need both bisoprolol and hydrochlorothiazide, to control their condition effectively.

How does Lodoz 2.5 Tablet work?

Lodoz 2.5 Tablet contains bisoprolol, which reduces the workload on the heart, and hydrochlorothiazide, a diuretic that increases urine production, both helping lower blood pressure.

Can I take Lodoz 2.5 Tablet with food?

Yes, you can take Lodoz 2.5 Tablet with or without food. The tablet should be swallowed whole with an adequate amount of liquid.

Is Lodoz 2.5 Tablet safe during pregnancy?

Lodoz 2.5 Tablet is not recommended during pregnancy, especially in the second and third trimesters. Always consult your doctor for advice.

Can Lodoz 2.5 Tablet cause any side effects?

Yes, potential side effects include fatigue, dizziness, low heartbeat rate (bradycardia), stomach disturbances such as nausea or vomiting, and electrolyte imbalances like low potassium levels (hypokalaemia).

What precautions should I take when using Lodoz 2.5 Tablet?

Monitor for signs of heart failure and changes in blood glucose levels while using this medicine. Avoid abrupt discontinuation without consulting your doctor.

How should I store my Lodoz 2.5 Tablets?

Store your tablets at room temperature (15-30°C) in a tightly closed container, protected from light and moisture.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

U.S. National Library of Medicine. (2022). Bisoprolol: MedlinePlus Drug Information. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a693024.html
U.S. National Library of Medicine. (2022). Hydrochlorothiazide: MedlinePlus Drug Information. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a682571.html
U.S. Food and Drug Administration. (2011). ZEBETA (bisoprolol fumarate) label. AccessData. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019982s016lbl.pdf
U.S. Food and Drug Administration. (2010). HCTZ (hydrochlorothiazide) label. AccessData. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020729s021lbl.pdf

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