Glucored 25400 Mg Tablet 10

Glucored Tablet 10

Sun Pharma Laboratories Ltd.

Strip of 10 Units

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MRP ~~₹50.5~~

₹41.41

₹5.05/Units

18% off applied

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Composition

Glibenclamide (2.5 Mg) + Metformin (400 Mg)

Glucored Tablet is designed to manage type 2 diabetes mellitus in adults. This medicine is a combination of two active ingredients that fall under the category of oral antidiabetic medication. It's primarily used when dietary adjustments, exercise and single agent therapy are not enough for maintaining adequate glycemic control.

Apart from its main use, this tablet is also beneficial for patients who initially responded positively to one active ingredient and need additional control over their blood sugar levels. Additionally, it's often recommended when type 2 diabetes isn't adequately controlled with metformin alone.

You must take this medicine as directed by your doctor. Before starting this tablet, inform your doctor about any ongoing medications or pre-existing conditions. If you notice any side effects while taking this medicine, immediately notify your doctor. For optimal results, continue taking the medicine for the duration your doctor prescribes.

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Glucored Tablet is used for the following:

Improving blood sugar control in adults with type 2 diabetes mellitus
Assisting in managing your type 2 diabetes when diet and exercise alone don’t provide adequate control
Helping those patients who initially responded well to glibenclamide alone but need extra help to control their blood sugar
Supporting patients whose blood sugar is not adequately controlled on metformin alone

Directions for Use of Glucored Tablet 10

Here's how you should take Glucored Tablet:

Swallow the tablet whole with a glass of water.
Do not crush, chew or break the tablet.
Always take this medicine with meals.
If you're unsure about any aspect of this medicine, consult your doctor for specific advice.

Glucored Tablet is taken orally.

While taking Glucored Tablet, you may encounter the following side effects:

Hypoglycaemia: This is a condition where your blood sugar levels drop lower than normal. You might feel shaky, hungry, or dizzy.
Diarrhoea
Nausea
Vomiting
Abdominal pain
Metallic taste: You may notice that food and drink have a different, often unpleasant, taste.
Vitamin B12 deficiency: Long-term use of the medication can cause your body to absorb less vitamin B12 than it needs. This can lead to tiredness, light-headedness and loss of appetite.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Glucored Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage common side effects:

Hypoglycaemia: Keep handy a quick source of sugar like glucose tablets, honey or fruit juice.
Diarrhoea: Try taking Glucored Tablet with meals and ensure you stay well hydrated.

Glucored Tablet contains two active ingredients that work together to lower blood glucose levels:

Glibenclamide (2.5 mg): This second-generation sulfonylurea stimulates more insulin secretion from the pancreatic beta cells by binding to and inhibiting ATP-sensitive potassium channels on the pancreatic beta cell membrane. This action leads to cell membrane depolarization and increased intracellular calcium, stimulating insulin secretion.
Metformin (400 mg): As a biguanide, metformin operates by decreasing hepatic glucose production and intestinal absorption of glucose whilst enhancing insulin sensitivity. This improves glucose uptake and utilisation in the body's periphery. Metformin activates AMP-activated protein kinase (AMPK), a liver enzyme that plays a significant role in insulin signalling and the metabolism of glucose and fats.

Pregnancy

Glucored Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Glucored Tablet is contraindicated for breastfeeding/lactating women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Avoid consuming alcohol while taking Glucored Tablet as it can lead to increased risks of side effects such as lactic acidosis. It's best to consult your doctor for guidance.

Liver

Caution is advised while taking Glucored Tablet in case of liver impairment. This medicine may affect liver function. If you have liver problems, discuss them with your doctor before starting Glucored Tablet.

Kidney

Glucored Tablet is contraindicated in severe renal impairment cases. If you have kidney problems, it's important to discuss this with your doctor before starting on this medicine.

Using Machines & Driving

Taking Glucored Tablet may cause side effects like dizziness or blurred vision which may affect your ability to drive or operate machinery. Take extra caution until you know how the medicine affects you.

Allergy

If you're allergic to glibenclamide or metformin, do not take Glucored Tablet. Consult your doctor for alternatives if you have known allergies.

Children

Glucored Tablet is not recommended for use in children under 18. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Glucored Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Glucored Tablet interacts with the following medicines:

Thiazides and Other Diuretics: Medicines such as hydrochlorothiazide and furosemide can lead to high blood sugar levels when taken alongside Glucored Tablet.
Corticosteroids: Medicines like prednisolone and dexamethasone can cause increased blood sugar levels when taken with Glucored Tablet.
Oral Contraceptives: Use of contraceptive pills like estradiol may result in raised blood sugar levels if used in conjunction with Glucored Tablet.
Phenothiazines: Medications like chlorpromazine when taken with Glucored Tablet may result in increased blood sugar levels.
Sympathomimetics: Medicines such as epinephrine and salbutamol can increase blood glucose levels when taken with this medicine.

Drug-Food Interactions

Certain foods may interact with Glucored Tablet.

High-sugar Foods: Consuming foods high in sugar while on this medication can lead to fluctuating blood glucose levels.

Drug-Disease Interactions

Glucored Tablet interacts with the following diseases:

Diabetic Ketoacidosis: Glucored Tablet is not recommended for those suffering from diabetic ketoacidosis as it might exacerbate the condition.
Severe Renal Impairment: This medicine should not be used by patients with severe renal impairment as it could worsen their condition.
Hepatic Impairment: People with liver disease should avoid using this medication as it might worsen their condition.

Daily Dose

The daily dose of Glucored Tablet should be taken as directed by your doctor. The dosage might vary based on factors such as your health condition and how well you respond to the medicine. Sticking to the prescribed dosage and avoiding exceeding it without consulting your doctor is crucial.

Over Dose

If you accidentally take more Glucored Tablet than prescribed, you could experience symptoms such as feeling dizzy, sweating excessively, or feeling unusually hungry. If you notice these or any other unusual symptoms, inform your doctor promptly.

Missed Dose

If you forget to take a dose of Glucored Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never alter your dosage without consulting your doctor.

Store Glucored Tablet in a dry place, away from direct sunlight or heat.
Do not expose the medicine to excessive moisture or air.
Always keep this medicine out of reach of children.
Remember to use Glucored Tablet before its expiry date.

Limit your intake of sugary foods and beverages. This will aid the action of Glucored Tablet in managing your blood sugar levels.
Regular physical exercise, such as walking or light jogging, can help enhance the effectiveness of Glucored Tablet by increasing your body's sensitivity to insulin.

Fact Box

Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is Glucored Tablet used for?

Glucored Tablet is used to manage type 2 diabetes in adults when diet, exercise, and single-agent therapy don't provide adequate blood sugar control.

How does Glucored Tablet work?

The medicine combines glibenclamide, which stimulates insulin secretion, and metformin, which reduces glucose production and absorption and improves insulin sensitivity.

How should I take Glucored Tablet?

The tablet is taken orally and swallowed whole with a glass of water. It shouldn't be crushed, chewed or broken.

What are some side effects of Glucored Tablet?

Common side effects include low blood sugar, diarrhoea, nausea, vomiting, abdominal pain, and metallic taste. Rare but serious side effects can occur.

Are there any precautions I should be aware of before taking Glucored Tablet?

Yes, the medicine should not be used if you have severe renal impairment, liver dysfunction or acute alcohol intoxication, among other conditions.

Does Glucored Tablet interact with other medicines?

Yes, it can interact with diuretics, corticosteroids, thyroid products, and oral contraceptives, among others. You should consult your doctor about all your medications.

How should I store my Glucored Tablet?

Store the tablets at room temperature in a dry place and keep them out of reach of children.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

sanofi-aventis. (n.d.). Glibenclamide tablets I.P - DAONIL / SEMI-DAONIL [Report]. https://www.sanofi.in/dam/jcr:8abc6b9c-523f-44d4-bdf4-1456aa645a9a/Daonil%C2%AE%20and%20Semi-Daonil%C2%AEPI.pdf
BP. (2021). GLIBENCLAMIDE TABLETS [Pharmaceutical Information]. In Product Information (p. 1.5). Confidential. https://rwandafda.gov.rw/wp-content/uploads/2024/02/Glibenclamide%205mg%20tablet-SmPC.pdf
Glyburide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01016
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331

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