Glizid Total P 6015500 Mg Tablet Sr 10

Glizid Total P 15 Tablet 10

Mankind Pharmaceuticals Ltd.

Strip of 10 Units

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Composition

Gliclazide (60 Mg) + Metformin (500 Mg) + Pioglitazone (15 Mg)

Glizid Total P15 Tablet is primarily used to manage type 2 diabetes mellitus in adults. This combination medicine is part of a group known as antidiabetic medicines.

In addition to its main use, this medicine also helps prevent complications associated with diabetes, such as kidney damage, blindness, nerve problems, and cardiovascular issues. It's particularly useful when diet, exercise, and single-agent therapy are not enough for controlling blood sugar levels.

This medicine should be taken orally as directed by your doctor. Before starting this medicine, inform your doctor about any pre-existing conditions or ongoing medicines you are on. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking the medicine for the duration prescribed by your doctor for optimal results.

Glizid Total P15 Tablet is used for the following:

Managing adult type 2 diabetes mellitus
Helping to control blood sugar levels
Preventing complications related to diabetes like kidney damage
Averting nerve problems linked to high blood sugar levels
Reducing the risk of blindness due to diabetic retinopathy
Lowering the likelihood of cardiovascular issues associated with diabetes

Directions for Use of Glizid Total P 15 Tablet 10

Here's how you should take Glizid Total P15 Tablet:

Swallow the tablet whole with a sufficient amount of water.
Do not crush, chew, or break the tablet as it is a sustained release (SR) formulation.
It is often recommended to take this medicine with breakfast.
Remember, altering your dosage without your doctor's advice can cause complications. So, always consult your doctor if you think your current dose isn't working well.

Glizid Total P15 Tablet is taken orally.

Side Effects of Glizid Total P 15 Tablet 10

Here are some common side effects you may experience with Glizid Total P15 Tablet:

Nausea
Vomiting
Diarrhoea
Abdominal pain
Loss of appetite and a metallic taste in your mouth
Headache and dizziness
Weakness
Hypoglycaemia: This is when your blood sugar drops too low. It can lead to feeling shaky, sweaty, and very hungry.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Glizid Total P15 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing common side effects:

Nausea or Diarrhoea: Try taking the medicine with meals.
Hypoglycaemia: You can manage this by consuming sugar or glucose tablets when symptoms first appear. After this, have a regular meal.

Glizid Total P15 Tablet contains three active ingredients:

Metformin (500 mg): As a biguanide, metformin works to reduce the production of glucose in your liver, and increases insulin sensitivity. This leads to improved glucose uptake and utilisation by your body's tissues.
Gliclazide (60 mg): This sulfonylurea class of medicine works by stimulating your pancreas to release more insulin, which helps lower blood glucose levels.
Pioglitazone (15 mg): This thiazolidinedione enhances insulin sensitivity in your muscle, fat, and liver cells. This action allows for better glucose utilisation and helps keep blood sugar levels under control.

Pregnancy

Caution is advised while taking Glizid Total P15 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you're breastfeeding, it's recommended to discuss the potential benefits and risks with your doctor before starting Glizid Total P15 Tablet.

Alcohol

Drinking alcohol might increase the risk of lactic acidosis with metformin, one of the components of Glizid Total P15 Tablet. It's advisable to minimise alcohol consumption while on this medication.

Liver

Glizid Total P15 Tablet should be used with caution in case of mild to moderate liver impairment. Severe liver diseases might require a different approach. Consult your doctor if you have liver problems before starting this medicine.

Kidney

If you have a history of kidney problems, caution is advised before using Glizid Total P15 Tablet. Your doctor will guide you based on your health status.

Using Machines & Driving

Glizid Total P15 Tablet may cause symptoms like dizziness or weakness. If affected, avoid driving or operating heavy machinery until you feel better.

Allergy

If you're allergic to metformin, gliclazide, pioglitazone, or any other ingredients in Glizid Total P15 Tablet, do not take this medicine without discussing it with your doctor.

Children

This medicine should not be given to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Glizid Total P15 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Interactions of Glizid Total P 15 Tablet 10

Drug-Drug Interactions

Glizid Total P15 Tablet interacts with the following medicines:

Insulin and other antidiabetic agents: This may increase the risk of hypoglycaemia or low blood sugar as both Glizid Total P15 Tablet and these medications work to reduce blood glucose levels. Examples include insulin glargine and glimepiride.
Corticosteroids: These medicines, such as prednisolone and dexamethasone, may decrease the efficacy of Glizid Total P15 Tablet in controlling blood sugar levels.
Thyroid hormones: Medicines like levothyroxine or liothyronine may reduce the efficacy of Glizid Total P15 Tablet in managing blood sugar.
Estrogens: Hormonal contraceptives or hormone replacement therapy containing estrogens like ethinylestradiol can reduce the effectiveness of Glizid Total P15 Tablet.

Drug-Food Interactions

Certain foods can affect how Glizid Total P15 Tablet works. For instance:

High fibre foods: Foods high in fibre may decrease the absorption of metformin, one of the active ingredients in Glizid Total P15 Tablet, affecting its efficacy.

Drug-Disease Interactions

Glizid Total P15 Tablet interacts with the following diseases:

Kidney disease: The tablet should be used with caution in patients with kidney disease as metformin is eliminated by the kidneys and might accumulate in patients with impaired renal function.
Liver disease: Patients with liver impairment should use caution as liver disease can affect the metabolism and elimination of gliclazide, metformin, and pioglitazone present in Glizid Total P15 Tablet.
Heart failure: Patients with a history of heart failure should avoid using this tablet as pioglitazone can cause fluid retention leading to heart failure.
Bladder cancer: Pioglitazone, an ingredient in Glizid Total P15 Tablet, may increase the risk of bladder cancer. Any symptoms such as blood in the urine or pain during urination should be reported to the doctor.

Daily Dose

Your doctor will prescribe the exact daily dose of Glizid Total P15 Tablet for you. The dosage may vary based on your health condition and response to the medicine.

Over Dose

In case of an accidental overdose of Glizid Total P15 Tablet, you might feel nauseous or dizzy. If these symptoms persist or worsen, do inform your doctor.

Missed Dose

Take it as soon as you remember. However, if it's almost time for the next dose, skip the missed one.

Store Glizid Total P15 Tablet at room temperature, ideally below 30°C.
Keep the medicine in a dry place, protected from exposure to light and moisture.
It's important to keep this medicine out of reach of children.
Always check the expiry date and make sure you use the medicine before it expires.

Incorporate a balanced diet with a good intake of fibre-rich foods like whole grains, fruits, and vegetables. This can help manage your blood sugar levels more effectively.
Regular physical activity is beneficial. Try to include at least 30 minutes of moderate-intensity exercise like brisk walking or cycling in your daily routine; it can help enhance insulin sensitivity and manage type 2 diabetes better.

Fact Box

Drug Category	Biguanide, Sulfonylurea, Thiazolidinedione
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet SR
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What Is Glizid Total P15 Tablet Used For?

It's a medication used to manage type 2 diabetes in adults, helping to control blood sugar levels and prevent related complications.

How Does This Medicine Work?

This tablet contains metformin, gliclazide, and pioglitazone. These ingredients work together to increase insulin release, improve insulin sensitivity, and decrease liver glucose production.

Can I Break or Chew the Tablet?

No, you should swallow the Glizid Total P15 Tablet whole with water. It's a sustained-release tablet and breaking it may disrupt its effectiveness.

What are some common side effects?

You might experience nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste in the mouth, headache, dizziness, weakness, or hypoglycaemia.

What should I do If I experience hypoglycaemia?

If you experience hypoglycaemia (low blood sugar), consume glucose tablets or a quick source of sugar immediately. Follow this up with a regular meal.

Are there any precautions I should take while using this medicine?

Yes. Monitor your weight regularly as this medicine may cause weight gain. Also undergo regular blood tests to monitor your kidney and liver function.

Can Glizid Total P15 Tablet interact with other medications?

Yes. It can interact with other medicines like insulin and corticosteroids. Always inform your doctor about any other medications you're currently taking before starting this medicine.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

Gliclazide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01120
Sarkar, A., Tiwari, A., & Jaipur National University. (2011). Pharmacological and Pharmaceutical Profile of gliclazide: a review. In Journal of Applied Pharmaceutical Science (Vol. 01, Issue 09, pp. 11–19). https://japsonline.com/admin/php/uploads/253_pdf.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Metformin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696005.html
Pioglitazone: uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01132
PubChem. (n.d.). Pioglitazone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Pioglitazone

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