Ampiclox Omega Capsule 10

Ampiclox Capsule 10

Omega Biotech Ltd

Strip of 10 Units

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MRP ~~₹75~~

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Composition

Ampicillin (250 Mg) + Cloxacillin (250 Mg)

Ampiclox Tablet is a combination antibiotic used to treat various bacterial infections. As a semi-synthetic derivative of penicillin, it effectively manages respiratory tract infections, urinary tract infections, and infections of the stomach or intestines. It is also used to treat conditions like meningitis and gonorrhea.

Additionally, Ampiclox helps prevent infections after surgeries and is useful in treating skin, soft tissue, bone, and joint infections. It works by inhibiting bacterial cell wall synthesis, thus stopping the growth and spread of bacteria in the body.

Before you start taking this medicine, it's crucial to consult your doctor for the right dosage and frequency. Make sure you inform your doctor about any pre-existing conditions or ongoing medications you might be on. If you notice any side effects while on this medicine, notify your doctor immediately.

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Ampiclox Tablet is a combination antibiotic used to treat various bacterial infections, including respiratory and urinary tract infections, stomach infections, meningitis, and gonorrhea. It is also effective in preventing post-surgical infections and treating skin, soft tissue, bone, and joint infections by inhibiting bacterial growth.

Directions for Use of Ampiclox Capsule 10

Ampiclox Capsule should be taken following these guidelines:

Thoroughly follow the dosage and timing guidelines provided by your doctor for taking this medicine.
Do not change or exceed the prescribed dose without consulting your doctor.
Avoid discontinuing this medication without your doctor's advice. Always consult your doctor before stopping.
Adhere to the diet plan recommended by your doctor.

Ampiclox Capsule is taken orally.

The use of Ampiclox Capsule may lead to the following side effects:

Diarrhoea
Nausea
Vomiting
Rash
Fatigue
Glossitis: This refers to inflammation or infection of the tongue, leading to swelling and a change in colour.
Stomatitis: This is a condition that causes painful swelling inside the mouth.
Black "hairy" tongue: This is a harmless condition where the tongue appears black and furry due to overgrown papillae.
Urticaria: This is also known as hives, causing red, itchy bumps on the skin.
Pruritis: This term refers to intense itching on the skin.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Ampiclox Capsule. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a few tips to manage some common side effects:

Diarrhoea: Consume plenty of healthy fluids to avoid dehydration.
Nausea: Take the diet recommended by your doctor to avoid nausea and vomiting.

Ampiclox Capsule contain two active ingredients:

Ampicillin (250 mg): This component works by binding to and inactivating certain enzymes in your body called penicillin-binding proteins (PBPs). These proteins are essential for creating peptidoglycan – a key part of the bacterial cell wall structure. By disrupting this process, ampicillin weakens the cell wall.
Cloxacillin (250 mg): Cloxacillin acts as a guard for ampicillin by resisting the breakdown caused by penicillinase enzymes that some bacteria produce. This resistance extends the effectiveness of ampicillin even further.

Together, these components work synergistically to weaken the cell wall leading to lysis – or dissolution – causing susceptible bacteria to die off, thereby effectively managing the infection.

Pregnancy

Ampiclox Capsule should only be used during pregnancy if absolutely necessary and if the benefits outweigh the potential risks. It's best to consult your doctor before taking this medicine if you are pregnant.

Breastfeeding

The active ingredients in Ampiclox Capsule pass into breast milk. Therefore, caution is advised if you are breastfeeding. It's recommended to discuss this with your doctor.

Alcohol

There is no known interaction between alcohol and Ampiclox Capsule. However, it's always a good idea to minimise alcohol intake when unwell.

Liver

Ampiclox Capsule should be used with caution if you have liver problems, especially if you have a history of jaundice or hepatic dysfunction associated with prior penicillin treatment. Discuss any liver health concerns with your doctor before starting this medicine.

Kidney

If you have any kidney issues, caution is required when taking Ampiclox Capsule. Dosage adjustment might be needed as both ampicillin and cloxacillin are mainly excreted via the kidneys.

Using Machines & Driving

Ampiclox Capsule may cause side effects like dizziness or fatigue, which could affect your ability to drive or operate machinery. It's advisable to understand how you react to the medicine before engaging in these activities.

Allergy

This medicine is contraindicated if you're allergic to penicillins, cephalosporins, or any component of the formulation. If you've had allergies, asthma, or hay fever in the past, use Ampiclox Capsule with caution.

Children

The safety and effectiveness of Ampiclox Capsule have been established in children. However, dosage adjustment based on weight is necessary. Always check with your doctor before giving this medicine to a child.

Older Patients

Older patients might be more susceptible to the side effects of Ampiclox Capsule and may often have liver or kidney concerns. It is recommended that they use this medicine under medical supervision. Your doctor will guide you based on the patient's overall health status.

Drug-Drug Interactions

Ampiclox Capsule interact with the following medicines:

Bacteriostatic Antibiotics: Medicines such as tetracyclines, chloramphenicol, erythromycin and sulfonamides might interfere with Ampiclox Capsule's action against bacteria.
Gout Medicines: Probenecid can increase the levels of ampicillin and cloxacillin by slowing down their removal from the body.
Contraceptives: Ampicillin could reduce the effectiveness of oral contraceptives, possibly leading to an unintended pregnancy.

Drug-Food Interactions

Food does not typically interfere with the absorption of Ampiclox Capsule.

Drug-Disease Interactions

Ampiclox Capsule interacts with the following diseases:

Liver Disease: If you have liver disease, you should use Ampiclox Capsule cautiously, as it may worsen your condition.
Kidney Disease: People with kidney disease may need a lower dosage as these medicines are primarily removed from your body through your kidneys.
Allergies, Asthma or Hay Fever: Use this medicine carefully if you have these conditions as it may trigger an allergic reaction.

Daily Dose

The daily dose of Ampiclox Capsule should be taken as recommended by your doctor. The prescribed dosage is personalised, considering factors like the severity of your condition and how you respond to the medicine.

Over Dose

If an overdose occurs, you might experience symptoms such as stomach upset or skin rashes. If these symptoms persist or worsen, it's essential to inform your doctor without delay.

Missed Dose

If you forget to take your Ampiclox Capsule at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the one you missed and continue with your regular schedule. Please don't increase your dosage without consulting your doctor.

Ensure Ampiclox Capsule is stored below 25°C.
Keep the capsule in a dry place, shielded from light.
Remember to store this medicine out of children's reach.
Always check the expiry date and refrain from using past its validity.

To help manage respiratory tract infections like bronchitis and pneumonia, ensure you or your child maintain adequate hydration. Drinking warm fluids like soups can provide relief from symptoms.
For skin infections, maintain good hygiene practices such as washing hands regularly to prevent the spread of infection. Regular cleaning of wounds also aids in preventing skin and soft tissue infections.

Fact Box

Drug Category	Cell Wall Synthesis Inhibitor
Therapeutic Category	Antibiotic
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Bronchitis, Pneumonia, Cellulitis

What is Ampiclox Capsule used for?

Ampiclox Capsule is used to manage a range of bacterial infections, including respiratory, urinary tract, skin, dental, and gastrointestinal infections. It's also employed prophylactically before certain surgeries.

How does Ampiclox Capsule work?

This medicine contains two antibiotics that work together to weaken the walls of disease-causing bacteria. This leads to the bacteria breaking apart and dying, thereby managing the infection.

Can I take Ampiclox Capsule with food?

Take your medicine exactly as prescribed by your doctor.

What are the common side effects of Ampiclox Capsule?

Common side effects include diarrhoea, nausea, vomiting, mouth sores, black "hairy" tongue, skin rash, itching and swelling (urticaria), headaches, dizziness and fatigue.

Can Ampiclox Capsule interact with other medicines?

Yes. It can interact with other antibiotics like tetracyclines, erythromycin and sulfonamides. Additionally, probenecid may increase its levels and ampicillin may reduce the efficacy of oral contraceptives and methotrexate.

Is Ampiclox Capsule safe during pregnancy and breastfeeding?

Ampiclox Capsule is recommended in pregnancy only if clearly needed and benefits outweigh risks. Since both active ingredients are excreted in breast milk, use cautiously during lactation.

What should I do in case of overdose?

In the case of overdose, symptoms like neurological irritation or convulsions occur. Immediately contact your doctor. Treatment includes gastric lavage and general supportive measures, along with monitoring kidney function.

Last Updated On 23 Sep. 2024 | 3:35PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

Dr. Reddy’s Laboratories Inc. (1974). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. In AMOXIL (pp. 1–17). https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050542s026s027s028,050754s013s014s017,050760s012s013s015,050761s012s013s015lbl.pdf
Teva Canada Limited. (2020). TEVA-CLOXACILLIN. In PRODUCT MONOGRAPH. https://pdf.hres.ca/dpd_pm/00055444.PDF
AMPICLOX. (n.d.). AMPICLOX. https://assets.gskstatic.com/pharma/PM-PI_portal/Tanzania/ampiclox_tz.pdf
Ampicillin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00415
Cloxacillin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01147

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