Trifluoperazine
Uses of Trifluoperazine
Trifluoperazine is used to manage schizophrenia and belongs to the category of antipsychotic medicines, specifically the phenothiazine group.
In addition to this primary use, Trifluoperazine also has applications in managing anxiety over short periods and controlling nausea and vomiting.
Side effects of Trifluoperazine
Drowsiness
Dizziness
Dry mouth
Constipation
Blurred vision
How Trifluoperazine works
Trifluoperazine is an antipsychotic medicine, part of the group called phenothiazines.
It functions by interfering with the actions of certain chemicals in the brain, more specifically, dopamine. It blocks the effects of dopamine, a neurotransmitter that transmits signals in the brain and other areas of the body, in specific pathways of the brain. This prevents excessive activity of dopamine and helps to regulate mood and behaviour, thus helping to manage symptoms of conditions like schizophrenia and anxiety. Additionally, Trifluoperazine's antiemetic effects, which help control nausea and vomiting, are likely due to it blocking dopamine receptors in a specific area of the brain known as the chemoreceptor trigger zone.
Certified content
Written By
BDS, MDS
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Trifluoperazine can be taken orally (tablet or concentrate solution) and intramuscularly (injection).
Age and Dose Restrictions
This medicine is primarily meant for adults; it can be given to children above the age of 12 years under the supervision of a doctor.
Contraindications
Trifluoperazine is contraindicated in individuals who have a known hypersensitivity to it or other phenothiazines. This medicine should not be given to patients in comatose or severely obtunded states. It is contraindicated in patients with liver damage or blood dyscrasias such as agranulocytosis or severe leukopenia. Patients with bone marrow depression should also avoid this medicine.
Other Medications to Avoid
Trifluoperazine can interact with sedatives (e.g., alcohol, opioids, and benzodiazepines), dopaminergic antiparkinson medicines (e.g., levodopa), and tricyclic antidepressants (e.g., imipramine).
Overdose and Missed Dose
Overdose of Trifluoperazine may lead to severe drowsiness, confusion, extrapyramidal symptoms, neuroleptic malignant syndrome, respiratory depression, hypotension, and cardiac arrhythmias. If you notice these symptoms, consult your doctor immediately.
If you miss a dose of Trifluoperazine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage drowsiness or dizziness, try to take the medicine at bedtime.
For dry mouth, sip water regularly or use a saliva substitute.
Use in Driving and Operating Machinery
This medicine may affect your ability to drive or operate heavy machinery due to possible side effects such as drowsiness and dizziness. You should not drive or operate heavy machinery until you know how this medicine affects you.
Use in Pregnancy and Lactation
Trifluoperazine should only be used during pregnancy if absolutely necessary because it can cause problems in newborns. Talk to your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with a history of cardiovascular disease or subcortical brain damage should exercise caution when taking Trifluoperazine.
Use very cautiously in patients with Parkinson's disease due to the risk of significantly worsening symptoms.
Special Dietary and Lifestyle Recommendations
Regularly practise relaxation techniques such as deep breathing, yoga, or meditation to help manage anxiety levels.
Frequently asked questions
Can I stop taking Trifluoperazine if I feel better?
No, you should not stop taking Trifluoperazine without consulting your doctor. This medication should be used for the entire duration prescribed by your doctor to manage your condition effectively.
How soon can I expect to see improvement in my symptoms after starting Trifluoperazine?
Typically, you may start noticing an improvement in your symptoms within 1-2 weeks of starting Trifluoperazine. However, it may take several weeks for the full effect to be observed. Remember to continue taking the medication as prescribed by your doctor, even if you do not notice immediate improvement.
Will taking Trifluoperazine have an impact on my mood?
Trifluoperazine is an antipsychotic medication and works by balancing certain chemicals in the brain that may affect mood and behaviour. However, if you experience any unusual changes in mood while taking this medicine, you should consult your doctor immediately.
Can Trifluoperazine cause addiction or dependence?
Trifluoperazine is not known to cause addiction or dependence. However, it is important to use this medication only as prescribed by your doctor.
Is there a specific time when I should take Trifluoperazine?
The timing for taking Trifluoperazine may depend on the dose and your individual treatment plan. It is important to take this medication exactly as prescribed by your doctor.
Is Trifluoperazine a steroid?
No, Trifluoperazine is not a steroid. It belongs to a group of medicines known as phenothiazine derivative antipsychotics, which are used primarily for managing conditions like schizophrenia and short-term anxiety.
Will Trifluoperazine affect fertility?
While some antipsychotics might potentially impact fertility due to their influence on hormonal levels, any specific effects of Trifluoperazine on fertility have not been mentioned in the available research data. As always, consult your doctor for more personalised advice.
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