Tretinoin
Uses of Tretinoin
Tretinoin's primary use is in managing acne and fine wrinkles, dark spots, and rough skin on the face caused by sun damage. It belongs to the class of medications known as retinoids.
Apart from these skin-related uses, Tretinoin is also used in the management of acute promyelocytic leukaemia, a rare type of blood cancer.
Side effects of Tretinoin
Skin redness
Peeling or scaling of the skin
Sensation of burning or stinging
Increased sensitivity to sunlight
Dry skin
How Tretinoin works
Tretinoin is a retinoid, a form of vitamin A.
It modifies the growth and differentiation of skin cells in several ways. Firstly, it promotes cell turnover in the skin, resulting in the exfoliation of old dead cells. Secondly, it unclogs pores by removing excess sebum and debris, which is beneficial for acne-prone skin. Thirdly, it reduces inflammation in the skin, helping to manage acne. Lastly, it stimulates the production of new collagen in the dermis layer of the skin, improving its overall appearance. When used for acute promyelocytic leukaemia, Tretinoin encourages the development of normal mature cells in the bone marrow.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Tretinoin is available for use via the topical route in the form of (creams, gels, lotions, and microsphere gel).
Age and Dose Restrictions
Tretinoin is typically prescribed for adults and teenagers above the age of 12 years.
Contraindications
The use of Tretinoin is contraindicated in patients with known hypersensitivity to Tretinoin or any of its inactive ingredients. It is also contraindicated in individuals with eczema, seborrhoeic dermatitis or excessively dry or sensitive skin.
Other Medications to Avoid
Tretinoin may interact with antipsoriatics (like resorcinol), antibacterial agents (like benzoyl peroxide), or salicylates (like salicylic acid).
Overdose and Missed Dose
Overdose of Tretinoin is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
If you forget to apply Tretinoin, it should be applied as soon as you remember. However, if it is almost time for your next application, skip the missed application and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Applying a gentle, non-medicated moisturiser can help manage dryness and peeling.
Avoiding direct sunlight and using a sunscreen with high SPF can help manage photosensitivity.
Use in Driving and Operating Machinery
Tretinoin does not have any known effects on the ability to drive or operate heavy machinery.
Use in Pregnancy and Lactation
Tretinoin is classified as pregnancy category C, which means risk cannot be ruled out. It is advised to consult your doctor before using Tretinoin during pregnancy or while breastfeeding.
Caution in Other Conditions
Care should be exercised in individuals with sunburned, irritated, abraded or infected skin. These conditions may exacerbate the side effects of Tretinoin.
Special Dietary and Lifestyle Recommendations
Regularly cleansing your face with a gentle, non-medicated cleanser can help manage acne.
Avoiding excessive sun exposure and using broad-spectrum sunscreen can help protect the skin against UV damage.
Drinking plenty of water helps keep the skin hydrated and supports its natural healing process.
Frequently asked questions
Does Tretinoin have any effect on mood?
Individual experiences may vary, and you should consult your doctor if you notice significant mood changes while using this medication.
Can Tretinoin be used for skin whitening?
Tretinoin is not typically used for skin whitening. It is primarily used to manage acne, fine wrinkles, dark spots, and rough skin caused by sun damage. However, it can improve the overall appearance of the skin over time.
Can Tretinoin cause weight gain?
Tretinoin can not directly lead to weight gain. If you have concerns about weight changes while using this medication, consult your doctor.
Does Tretinoin have an effect on menstruation?
Tretinoin does not have a direct effect on menstruation. However, if you notice any changes in your menstrual cycle while using this medication, it is advisable to consult your doctor.
Is Tretinoin safe for long-term use?
Tretinoin can be safe for long-term use under the supervision of a doctor. Your doctor will recommend the appropriate duration of use based on your specific condition and response to treatment.
Can Tretinoin be used to treat scars?
Although Tretinoin can help improve the texture and appearance of the skin, it is not specifically indicated for the treatment of scars. You should consult your doctor for appropriate treatments for scars.
Can Tretinoin be used for all skin types?
Most people can use Tretinoin unless they have extremely sensitive skin or skin conditions like eczema or seborrheic dermatitis. It is advisable to consult with a doctor before starting any new skincare regimen.
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