Repaglinide
Uses of Repaglinide
Repaglinide is primarily used to manage type 2 diabetes in adults. It belongs to a class of medications known as meglitinides that help control blood sugar levels.
Side effects of Repaglinide
Hypoglycemia
Upper respiratory tract infection
Headache
Sinusitis
Diarrhoea
How Repaglinide works
Repaglinide is an antidiabetic medication that falls under the category of meglitinides.
It acts by binding and closing the ATP-dependent potassium channels on pancreatic beta cells. This action causes the cell to depolarise, triggering a calcium influx. The influx of calcium stimulates the beta cells to release more insulin into the bloodstream. This insulin then facilitates the uptake of glucose by peripheral tissues and puts a stop to hepatic glucose production, thereby lowering blood glucose levels. The action of Repaglinide is glucose-dependent, which means when blood glucose levels are higher, more insulin is released.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Repaglinide can be taken orally (tablet).
Age and Dose Restrictions
This medicine is intended for use in adults with type 2 diabetes mellitus.
Contraindications
This medication is contraindicated in patients with type 1 diabetes mellitus and diabetic ketoacidosis. Repaglinide should not be used by individuals with known hypersensitivity to the active ingredient or any of the excipients. It is also contraindicated for patients with severe liver impairment.
Other Medications to Avoid
Repaglinide may interact with strong CYP3A4 (like itraconazole, and clarithromycin), CYP2C8 inhibitors (like gemfibrozil) and CYP2C8 inducers (like rifampin, and carbamazepine).
Overdose and Missed Dose
An overdose of Repaglinide can cause severe hypoglycaemia. If you suspect an overdose, consult a doctor immediately.
If you miss a dose, skip that dose if the meal was missed. If an extra meal is eaten, take an additional dose. Do not double your dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Consuming small and frequent meals can manage the symptoms of hypoglycaemia.
Drinking plenty of fluids may help manage diarrhoea.
Use in Driving and Operating Machinery
Repaglinide may cause side effects that can affect your ability to drive or operate machinery, such as dizziness. Avoid driving or operating heavy machinery until you know how this medication affects you.
Use in Pregnancy and Lactation
Consult your doctor if you are pregnant or breastfeeding before taking this medication.
Caution in Other Conditions
Patients with moderate to severe renal impairment and mild to moderate hepatic impairment should exercise caution when taking Repaglinide. Individuals with hypersensitivity reactions should also be cautious while using this medication.
Special Dietary and Lifestyle Recommendations
Regular monitoring of blood glucose levels is recommended for better disease management.
Regular check-ups are advised to monitor the condition effectively.
Frequently asked questions
Is Repaglinide a steroid?
No, Repaglinide is not a steroid. It is an oral anti-diabetic medication used for managing type 2 diabetes in adults.
Does Repaglinide have any effect on sleep?
Repaglinide is not directly associated with affecting sleep. However, if you experience unusual side effects such as insomnia or excessive sleepiness, consult your doctor immediately.
Will Repaglinide affect fertility?
Repaglinide is not directly associated with affecting fertility in humans. However, if you are planning a pregnancy or struggling with fertility issues, it is advisable to discuss this with your doctor.
Is it safe to take Repaglinide daily?
Yes, it is safe to take Repaglinide daily as prescribed by your doctor. This medication is meant for regular use to manage blood sugar levels effectively in people with type 2 diabetes.
How much time does Repaglinide take to work?
Repaglinide typically starts working within 30 minutes of intake to lower blood sugar levels and its effect lasts for about 4-6 hours.
What is the best time to take Repaglinide?
Repaglinide should be taken around 15-30 minutes before your main meals, as recommended by your doctor.
Is Repaglinide available over the counter, or do I need a prescription?
Repaglinide requires a doctor's prescription and is not available over the counter.
Repaglinide in other salts
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