Proanthocyanidin
Uses of Proanthocyanidin
- Proanthocyanidin is primarily used for its antioxidant and anti-inflammatory properties.
- It is a polyphenolic compound that helps manage conditions like chronic venous insufficiency, diabetic complications, and supports skin and oral health.
- By dilating constricted blood vessels, it improves blood flow and alleviates symptoms of varicose veins, such as itching, heaviness, swelling, and pain.
Side effects of Proanthocyanidin
Gastrointestinal discomfort
Headache
Skin rash
How Proanthocyanidin works
Proanthocyanidin is a class of beneficial polyphenolic compounds.
It works primarily by neutralising harmful free radicals, thus reducing oxidative stress and inflammation in the body. This antioxidant action helps protect cells and tissues from damage.
Proanthocyanidin also modulates the production of pro-inflammatory cytokines, compounds that promote inflammation. This helps to manage inflammatory conditions in various tissues.
Additionally, it improves endothelial function, which is crucial for blood vessel health. This can help manage cardiovascular health by reducing blood pressure and preventing LDL cholesterol oxidation.
Furthermore, it demonstrates neuroprotective properties by reducing oxidative stress and inflammation in the brain. This could potentially help in managing age-related cognitive decline and neurodegenerative disorders.
Certified content
Written By
Bachelor of Dental Surgery
Reviewed By
MSc (Applied Genetics)
Expert Advice
Dosage Forms Available
Proanthocyanidin can be taken orally as capsules, tablets, or dietary supplements. Additionally, the extract is available for topical use as creams and lotions in various skincare products.
Age and Dose Restrictions
Proanthocyanidin is generally safe for adults and children aged 12 years and above.
Contraindications
Proanthocyanidin is contraindicated in individuals with known hypersensitivity to any sources of proanthocyanidins, including certain fruits, nuts, and berries. Those having a history of bleeding disorders or who are due for surgery should also avoid its use due to its potential effects on blood clotting.
Other Medications to Avoid
Proanthocyanidin may interact with anticoagulants (e.g., warfarin) or antiplatelet medicines (e.g., aspirin), certain chemotherapy agents (e.g., doxorubicin and cyclophosphamide) and with iron supplements.
Overdose and Missed Dose
Overdosing on Proanthocyanidin can potentially lead to side effects such as nausea, stomach upset, or skin rash. If these symptoms persist or worsen, immediately consult your doctor.
If you have missed a dose of Proanthocyanidin, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed one and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor. To manage common side effects:
Drinking plenty of fluids can help manage potential gastrointestinal discomfort.
Taking the supplement with a meal can help reduce the chances of an upset stomach.
Use in Driving and Operating Machinery
There is no known effect of Proanthocyanidin on one's ability to drive or operate heavy machinery. However, if you feel drowsy or dizzy after taking the supplement, it is advisable to refrain from these activities.
Use in Pregnancy and Lactation
The safety of Proanthocyanidin use during pregnancy and lactation has not been thoroughly studied. Therefore, it is recommended that pregnant or breastfeeding women should consult their doctors before considering its use.
Caution in Other Conditions
Individuals with bleeding disorders or those awaiting surgery should exercise caution while taking Proanthocyanidin due to its potential effects on blood clotting. Those with Iron deficiency may also need to be cautious as this medication may interfere with iron absorption.
Special Dietary and Lifestyle Recommendations
There are no special dietary and lifestyle recommendations apart from maintaining a balanced diet rich in antioxidants, engaging in regular physical activity, reducing alcohol consumption and quitting smoking, getting adequate rest and sleep for overall well being.
Frequently asked questions
What is Proanthocyanidin?
Proanthocyanidin, often found in various plants such as grape seeds, pine bark, and red wine, is a type of polyphenolic compound. It is a part of the flavonoid family and is known for its anti-inflammatory and antioxidant properties.
Does Proanthocyanidin have any impact on sugar levels?
There is evidence suggesting that Proanthocyanidin can help manage diabetic complications by enhancing glucose metabolism and reducing oxidative stress.
Can Proanthocyanidin benefit oral health?
Yes, studies have shown that Proanthocyanidin can inhibit the growth of oral bacteria, preventing dental caries (tooth decay). It may also help reduce inflammation in the gums and promote overall periodontal (gum) health.
Is Proanthocyanidin beneficial for skin health?
Proanthocyanidin has been found to be beneficial for skin health owing to its antioxidant properties. It can protect the skin from damage caused by ultraviolet (UV) rays, stimulate collagen synthesis, and enhance skin elasticity and hydration.
Can Proanthocyanidin help with cardiovascular health?
Yes, Proanthocyanidin supports cardiovascular health by enhancing endothelial function, reducing platelet aggregation, reducing blood pressure levels, maintaining healthy cholesterol levels, and preventing oxidation of LDL cholesterol.
Can Proanthocyanidin help in managing oxidative stress?
Yes. Proanthocyanidin is known for its potent antioxidant properties. It protects cells and tissues from damage caused by oxidative stress by neutralising harmful free radicals.
I have heard that Proanthocyanidin has neuroprotective effects. Is this true?
Yes, Proanthocyanidin exhibits neuroprotective properties by reducing oxidative stress and inflammation in the brain, which may help in preventing age-related cognitive decline and certain neurodegenerative disorders.
Proanthocyanidin in other salts
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