Pregabalin + Nortriptyline
DRUGS FOR PERIPHERAL NEUROPATHYUses of Pregabalin + Nortriptyline
- Pregabalin + Nortriptyline are used together to treat neuropathic pain and are also effective in managing mental or mood disorders such as depression, anxiety, and tension. Pregabalin helps reduce nerve pain by calming overactive nerves, while Nortriptyline, a tricyclic antidepressant, improves mood and relieves symptoms of depression and anxiety.
Side effects of Pregabalin + Nortriptyline
- Blurred vision
- Weight gain
- Dry mouth
- Dizziness
- Sleepiness
- Nausea
How Pregabalin + Nortriptyline works
- Pregabalin works by blocking the opening of calcium channels within the central nervous system. This action helps to reduce the release of certain neurotransmitters, leading to a decrease in nerve pain and alleviation of symptoms associated with various types of neuropathic pain.
- Nortriptyline is a tricyclic antidepressant that works by increasing the levels of certain neurotransmitters (such as serotonin and norepinephrine) in the brain. It helps modulate the pain signals and provides relief from chronic pain.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Nortriptyline + Pregabalin is available for use via the oral route (tablets).
Age and Dose Restrictions
- This medicine is meant for adults and children above 6 years of age.
Contraindications
- This medicine is contraindicated in individuals with known allergies to Nortriptyline or Pregabalin and patients with recent heart attacks, liver issues, and heart issues, and in women who are breastfeeding.
Other Medications To Avoid With This Medicine
- Nortriptyline combined with Pregabalin may interact with various medications, including antidepressants (such as amitriptyline, duloxetine, mirtazapine, fluoxetine, sertraline, citalopram, escitalopram, and bupropion), painkillers (such as codeine, fentanyl, hydrocodone, morphine, oxycodone, tramadol, and acetaminophen), anti-convulsants (such as gabapentin, phenobarbital, phenytoin, clonazepam, and topiramate), anti-anxiety medications (such as diazepam and alprazolam), sedative-hypnotics (such as zolpidem), antihistamines (such as diphenhydramine and cetirizine), muscle relaxants (such as cyclobenzaprine), and antiemetics (such as ondansetron).
Overdose and Missed Dose
- An overdose of this medication may cause blurred vision, confusion, restlessness, dizziness, sleepiness, vomiting, rapid heart rate, and dry mouth, If you suspect an overdose of this medication, please visit the hospital immediately.
- If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.
Management Of Side Effects
- Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Use In Driving And Operating Machinery
- This medication may cause dizziness and sleepiness and can impair your ability to drive or operate machinery.
Use in Pregnancy and Lactation
- This medicine is not recommended in pregnancy and is contraindicated in breastfeeding women.
Caution In Other Conditions
- Patients with renal or hepatic conditions, diabetic patients, and patients with epilepsy should exercise caution when taking this medicine.
Special Dietary & Lifestyle Recommendation
- Make sure your diet has foods rich in vitamins B and D. Incorporate cayenne pepper into your meals to alleviate neuropathic pain.
- Regular exercise boosts overall health and reduces pain. Prioritize rest and aim for plenty of sleep each night. Relax with a soothing warm bath.
- Avoid smoking and limit alcohol intake. Practice meditation and yoga to reduce stress, enhance pain tolerance, and build coping skills.
- Consider using essential oils for massages to improve circulation.
Frequently asked questions
How much time does Nortriptyline + Pregabalin take to work?
This medicine's onset of action may require a few hours for full efficacy to be realised.
What warnings and precautions should I take while taking Nortriptyline + Pregabalin?
If you're allergic to this medicine, don't take it. Seek medical help right away if you have any allergic reactions. Also, exercise caution while taking this combination if you have liver, heart, or renal problems.
Can I stop taking Nortriptyline + Pregabalin if I feel healthy?
Please do not discontinue Nortriptyline + Pregabalin without consulting your doctor first. Abruptly stopping the medication may result in the return of symptoms.
Is it safe for patients with kidney or liver issues?
Patients with renal or hepatic conditions should exercise caution when taking this medicine.
Will Nortriptyline + Pregabalin affect fertility?
There is limited evidence on the effect of this medication on fertility, discuss it with your doctor before taking it.
Is Pregabalin + Nortriptyline used to treat diabetic neuropathy?
Yes, Pregabalin + Nortriptyline is commonly used to treat diabetic neuropathy. This combination helps relieve nerve pain associated with diabetes by modulating pain signals in the brain and improving mood.
Does Pregabalin + Nortriptyline cause oedema?
Yes, the use of Pregabalin + Nortriptyline can cause oedema (swelling) as a side effect. This is usually due to fluid retention and is more commonly seen in the legs and feet.
Does Pregabalin + Nortriptyline cause weight gain?
Yes, weight gain can be a side effect of Pregabalin + Nortriptyline. This may result from increased appetite, fluid retention, or changes in metabolism.
How to manage weight gain associated with the use of Pregabalin + Nortriptyline?
To manage weight gain, maintain a balanced diet, engage in regular physical activity, and monitor your weight regularly. Consult your doctor for personalized advice, as they may adjust your dosage or suggest alternative treatments.
Can the use of Pregabalin + Nortriptyline affect my sexual life?
Yes, Pregabalin + Nortriptyline may affect sexual life by causing side effects such as decreased libido, erectile dysfunction, or difficulty achieving orgasm. If you experience these issues, consult your doctor for guidance.
Pregabalin + Nortriptyline in other salts
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