Nitazoxanide + Ofloxacin is primarily used for the management of diarrhoea caused by parasitic infections of the intestines, such as cryptosporidiosis and giardiasis, and bacterial infections like pneumonia, bronchitis, urinary tract infections, prostatitis, skin, and soft tissue infections. This combination belongs to the group of fluoroquinolone antibiotics and antiprotozoal agents.
Depending on the infecting organisms and their antibiotic susceptibility patterns, this combination may also be used to manage a variety of other bacterial and parasitic infections.
Abdominal pain
Diarrhoea
Nausea
Vomiting
Headache
Nitazoxanide, the first component, is an antiprotozoal agent. It interferes with the energy metabolism of parasites by inhibiting an enzyme called pyruvate ferredoxin oxidoreductase (PFOR). This leads to the death of the parasitic cells.
Ofloxacin, the second component, is a fluoroquinolone antibiotic. It kills bacteria by stopping their DNA from replicating. It does this by interfering with two enzymes, DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication and other vital processes.
Doctor of Medicine
BMS, FMC, MD Resident
Nitazoxanide + Ofloxacin can be taken orally (tablet).
This medication is intended for use in adults and children above 12 years of age.
Nitazoxanide + Ofloxacin should not be used by individuals with known allergies to nitazoxanide, ofloxacin, or other quinolone antibiotics. It is also contraindicated in individuals suffering from hepatic encephalopathy or Clostridium difficile associated diarrhoea, and those with a history of tendon inflammation or rupture. Individuals with known glucose-6-phosphate dehydrogenase (G6PD) deficiency should avoid this medication.
The Nitazoxanide + Ofloxacin combination may interact with highly plasma protein-bound medicines (such as warfarin), multivitamins (such as those containing zinc), antidiabetic agents (like metformin), nonsteroidal anti-inflammatory medicines (such as ibuprofen), and certain antiarrhythmics (like amiodarone).
Overdosing on Nitazoxanide + Ofloxacin can result in symptoms like nausea, vomiting, epigastric distress, dizziness, and headache. If these symptoms are observed, professional medical help should be sought immediately.
In case of a missed dose of this medication, it should be taken as soon as one remembers. However, if it is near the time for the next dose, the missed dose should be skipped to prevent doubling up on dosage.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage diarrhoea and nausea, which are common side effects.
Rest and relaxation techniques can help manage headache and dizziness.
Nitazoxanide + Ofloxacin might affect the ability to concentrate, hence caution should be exercised while driving or operating heavy machinery.
Nitazoxanide + Ofloxacin is not recommended for use during pregnancy and lactation. It is always advised to consult a doctor before using this medicine during these periods.
Patients with kidney failure should exercise caution when taking Nitazoxanide + Ofloxacin as dose adjustments may be needed.
Individuals with conditions causing QT interval prolongation should also be cautious as this medication could potentially worsen the condition.
Maintain good personal hygiene to prevent recurrent infections.
Maintain proper hydration, especially if suffering from diarrhoea.
Avoid crowded places and contact with sick individuals to prevent catching infections.
Frequently asked questions
No, Nitazoxanide + Ofloxacin is not a steroid. It is a combination of two different types of medication: an antiprotozoal agent and a fluoroquinolone antibiotic.
While some people might experience insomnia as a side effect, it is not a common experience for everyone taking Nitazoxanide + Ofloxacin.
There are no known effects of Nitazoxanide + Ofloxacin on fertility. However, if you are planning to conceive, be sure to discuss it with your doctor.
Nitazoxanide + Ofloxacin should be taken as prescribed by the doctor. The duration and dose depend on the type and severity of the infection.
The time it takes for Nitazoxanide + Ofloxacin to work can vary depending on the type and severity of the infection. However, you should start to see some improvement within a few days.
Nitazoxanide + Ofloxacin should ideally be taken as directed by the doctor. The timing can vary based on your individual medical condition and the specific dosage prescribed.
Nitazoxanide + Ofloxacin is not available over the counter and requires a doctor's prescription.
Nitazoxanide + Ofloxacin in other salts
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