Mirabegron + Solifenacin
Uses of Mirabegron + Solifenacin
The primary use of Mirabegron + Solifenacin is to manage symptoms of an overactive bladder (OAB). This medication belongs to a class of medicines that includes both beta-3 adrenergic receptor agonists and antimuscarinic agents.
Side effects of Mirabegron + Solifenacin
High blood pressure (hypertension)
Common cold symptoms (nasopharyngitis)
Urinary tract infection
Headache
Constipation
How Mirabegron + Solifenacin works
Mirabegron falls under the category of beta-3 adrenergic receptor agonists. It stimulates the beta-3 adrenergic receptors present in bladder muscle cells, leading these cells to relax. As a result, the bladder's storage capacity increases.
Solifenacin is an antimuscarinic agent. Its action involves blocking M3 muscarinic receptors on bladder muscle cells. By doing so, it prevents involuntary bladder contractions, thus reducing the urge to urinate frequently and intensely.
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Expert Advice
Dosage Forms Available
Mirabegron + Solifenacin comes in the form of extended-release (tablets).
Age and Dose Restrictions
Mirabegron + Solifenacin is intended for use in adults only. It is not recommended for individuals under 18 years of age due to a lack of studies on safety and efficacy in this age group.
Contraindications
This medicine is contraindicated in individuals with known hypersensitivity to either mirabegron or solifenacin, as well as any of the excipients found in the tablets.
It is also contraindicated in patients with end-stage kidney disease or severe hepatic impairment, gastric retention, and uncontrolled narrow-angle glaucoma.
Other Medications to Avoid
This combination may interact with CYP2D6 enzyme substrates (such as thioridazine, flecainide, propafenone, metoprolol, and desipramine), antimuscarinic medications (such as oxybutynin, and tolterodine), and heart medications (digoxin).
Overdose and Missed Dose
In case of an overdose of Mirabegron + Solifenacin, medical attention should be sought immediately. Symptoms may include increased heart rate and severe dizziness.
If you miss a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and return to your normal dosage schedule. Do not double up doses to make up for a missed one.
Management of Side Effects
Most side effects of Mirabegron + Solifenacin are temporary and will subside after discontinuing the medication. However, if side effects persist or worsen, consult your doctor.
Drinking plenty of water can help to manage constipation and dry mouth.
Rest and relaxation techniques can help manage dizziness and fatigue.
Use in Driving and Operating Machinery
Mirabegron + Solifenacin may cause dizziness. If this occurs, avoid driving or operating heavy machinery until you are sure you can perform these activities safely.
Use in Pregnancy and Lactation
It is recommended to consult with your doctor before taking Mirabegron + Solifenacin if you are pregnant, planning to become pregnant, or breastfeeding. The effects of this medicine on the unborn baby are not well studied.
Caution in Other Conditions
Individuals with severe uncontrolled hypertension should exercise caution when taking this medicine. Also, patients with clinically significant bladder outlet obstruction, severe renal impairment or moderate hepatic impairment should consult their doctor before starting treatment.
Special Dietary and Lifestyle Recommendations
Regularly practising bladder training exercises can help manage symptoms of overactive bladder.
Reducing intake of diuretic substances such as caffeine and alcohol can also help manage symptoms.
Keeping a bladder diary can aid in understanding triggers for urinary urgency and frequency.
Frequently asked questions
Is Mirabegron + Solifenacin a type of steroid?
No, Mirabegron + Solifenacin is not a steroid. It is a combination medication used to manage symptoms of an overactive bladder (OAB). The combination consists of two active ingredients: mirabegron, a beta-3 adrenergic receptor agonist, and solifenacin, an antimuscarinic agent.
Does Mirabegron + Solifenacin have any impact on sleep?
There is no direct mention of Mirabegron + Solifenacin affecting sleep in the given research data. However, as it manages OAB symptoms—urgency, frequency, and incontinence—it could indirectly help improve sleep by reducing the need for frequent nighttime bathroom visits.
Can taking Mirabegron + Solifenacin affect fertility?
There is no specific mention in the research data about Mirabegron + Solifenacin affecting fertility. If you have concerns about fertility, it is advisable to consult your doctor when considering this medication.
How long does it take for Mirabegron + Solifenacin to work?
Some patients may notice improvement in symptoms within 2 weeks of starting the medication. However, it typically takes 4-8 weeks to experience the full effect of this medication.
Do I need a prescription for Mirabegron + Solifenacin, or is it available over the counter?
Mirabegron + Solifenacin is typically prescribed by a doctor and not available over the counter. Always follow your doctor's advice regarding its use.
Does Mirabegron + Solifenacin have a long-term effect on the body?
Mirabegron + Solifenacin is indicated for long-term management of overactive bladder symptoms in many patients. If taken as recommended by your doctor and regularly monitored, it should not pose any significant long-term risks to your health. However, any concerns should be discussed with your doctor.
Is Mirabegron + Solifenacin vegan-friendly?
The actual ingredients of medicines may vary by brand and country. Therefore, if you are concerned about the composition of your medication being suitable for your vegan lifestyle, it would be best to contact the manufacturer directly or consult with your pharmacist or doctor.
Mirabegron + Solifenacin in other salts
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