L-ornithinel-aspartate
DRUGS FOR HEPATIC ENCEPHALOPATHYUses of L-ornithinel-aspartate
- L-ornithinel-aspartate is used to treat various liver diseases, including acute and chronic hepatitis, chronic alcoholic liver damage, fatty liver, jaundice, liver cirrhosis, and non-alcoholic steatohepatitis (NAFLD).
- It works by reducing elevated ammonia levels in the blood, which is common in liver dysfunction.
- This medication helps improve liver function, supports detoxification, and promotes the regeneration of liver cells, thereby enhancing overall liver health in conditions caused by liver damage or impairment.
Side effects of L-ornithinel-aspartate
- Nausea
- Vomiting
How L-ornithinel-aspartate works
- L-ornithine and L-aspartate function by eliminating ammonia through L-ornithine, an intermediate in the urea cycle. This leads to enhanced urea synthesis in patients with cirrhosis and hepatic encephalopathy (HE). L-ornithine is also important for removing ammonia through the synthesis of glutamine in muscle and brain tissues.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- L Ornithine L Aspartate is available in tablets, capsules, syrup, and granules for oral use.
Age and Dose Restrictions
- This medicine is meant for adults above 18 years of age.
Contraindications
- This medicine is contraindicated in patients with known allergies to L Ornithine L Aspartate and patients with severe kidney problems.
Other Medications To Avoid With This Medicine
- Inform your doctor if you are taking any other medicines including over-the-counter medications with L Ornithine L Aspartate.
Overdose and Missed Dose
- If you take more medicine than you should, inform your doctor and follow the advice accordingly.
- If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.
Management Of Side Effects
- Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Use In Driving And Operating Machinery
- L-ornithine and L-aspartate do not typically impair the ability to drive or operate machinery. However, it's important to note that during treatment with L-ornithine and L-aspartate, your ability to perform these tasks may be affected by your illness. Therefore, it is advisable to refrain from using machinery until you have fully recovered from your condition.
Use in Pregnancy and Lactation
- This medicine is not recommended in pregnancy and breastfeeding. Always ask your doctor for advice before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding.
Caution In Other Conditions
- Patients with kidney or severe liver conditions should exercise caution when taking this medicine.
- Special Dietary & Lifestyle Recommendation
- To promote liver health, it's crucial to refrain from alcohol consumption and quit smoking. Additionally, maintaining a healthy weight through regular exercise is essential.
- Adopting a liver-friendly diet rich in fibre can also be beneficial while reducing the intake of fats, sugar, and salt.
- To manage stress, consider incorporating practices like yoga or meditation into your routine.
- Regular exercise is key, as it aids in reducing fat accumulation and supporting overall liver function.
Frequently asked questions
How much time does L Ornithine L Aspartate take to work?
The onset of action of this medicine may take a few weeks for full efficacy to be realised.
What warnings and precautions should I take while taking L Ornithine L Aspartate?
If you're allergic to this medicine, don't take it. Seek medical help right away if you have any allergic reactions. Also, exercise caution while taking this combination if you have kidney problems.
Can I stop taking L Ornithine L Aspartate if I feel healthy?
Please do not discontinue L Ornithine L Aspartate without consulting your doctor first. Abruptly stopping the medication may result in the return of symptoms.
Is it safe for patients with kidney or liver issues?
  Patients with kidney conditions and severe liver disease should exercise caution when taking this medicine.
Will L Ornithine L Aspartate affect fertility?
This medication may not affect your fertility, however, discuss it with your doctor before taking it.
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