L-isoleucine + L-leucine + L-valine
Uses of L-isoleucine + L-leucine + L-valine
The primary medical use of the combination of L-Isoleucine + L-Leucine + L-Valine is to manage nutritional deficiencies of these essential amino acids. They belong to the group of branched-chain amino acids (BCAAs).
Secondary uses of this combination include managing conditions like muscle wasting disorders, liver cirrhosis, phenylketonuria (limited natural protein intake), catabolic states (burns, trauma, sepsis), and cases of malnutrition and protein-energy undernutrition.
Side effects of L-isoleucine + L-leucine + L-valine
Nausea
Diarrhoea
Abdominal discomfort
Fatigue
Headache
How L-isoleucine + L-leucine + L-valine works
L-Isoleucine + L-Leucine + L-Valine is a branched-chain amino acids (BCAAs) supplement.
These BCAAs are essential for protein synthesis, particularly in skeletal muscle. This means they help our bodies build and repair muscles.
Specifically, L-Leucine activates a pathway in our cells (the mTOR pathway) that stimulates muscle protein synthesis. This plays a crucial role in muscle growth and recovery.
Additionally, these BCAAs are involved in the regulation of blood glucose. They promote the use of glucose by muscles, which could have potential benefits for individuals with diabetes.
L-Leucine may also play a role in managing weight by suppressing appetite.
Moreover, BCAAs compete with other types of amino acids, affecting the production of important neurotransmitters like serotonin and dopamine which are key to our mood and cognitive function.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
The medicine L-Isoleucine + L-Leucine + L-Valine is available in several forms for oral administration. These include tablets, capsules, and powders which are diluted in liquid to make a solution.
Age and Dose Restrictions
The L-Isoleucine + L-Leucine + L-Valine supplement can be taken by adults and children above the age of 12 years. However, it is always recommended to consult a doctor before giving these supplements to young children.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to any of its components.
It is also not advised for individuals with acute liver failure, amyotrophic lateral sclerosis (ALS), or branched-chain ketoaciduria – a rare inborn error of BCAA metabolism.
Other Medications to Avoid
L-Isoleucine + L-Leucine + L-Valine may interact with levodopa (used in Parkinson's disease), certain diabetes medications (such as metformin and insulin), corticosteroids (like prednisone), and thyroid hormones (such as levothyroxine).
Overdose and Missed Dose
Taking more than the recommended daily dose of these supplements may result in increased ammonia levels, causing symptoms like fatigue, headache, and nausea. Always consult your doctor if you suspect an overdose.
If you forget to take your daily dose of this supplement, take it as soon as you remember. However, avoid doubling up the dose to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage nausea or abdominal discomfort, you may try taking the supplement with a light snack or meal.
If you experience headaches or fatigue, ensure you are getting adequate rest and staying hydrated.
Use in Driving and Operating Machinery
L-Isoleucine + L-Leucine + L-Valine does not typically affect one's ability to drive or operate heavy machinery. However, if you experience fatigue or dizziness after taking this supplement, refrain from such activities.
Use in Pregnancy and Lactation
The use of L-Isoleucine + L-Leucine + L-Valine during pregnancy and lactation should be decided in consultation with your doctor.
Caution in Other Conditions
Individuals with renal impairment should use this medicine with caution, as increased ammonia levels could potentially exacerbate the condition.
Additionally, those with diabetes should monitor blood glucose levels closely while using this supplement, as it may affect blood glucose control.
Special Dietary and Lifestyle Recommendations
A balanced diet rich in protein will naturally provide essential amino acids including L-ISOLEUCINE, L-LEUCINE, and L-VALINE. Consuming protein-rich foods like lean meats, dairy products, and legumes can help meet nutritional needs.
Regular hydration is important to support overall health and wellbeing.
Maintain a regular sleep schedule to reduce potential fatigue associated with this supplement.
Frequently asked questions
Is L-Isoleucine + L-Leucine + L-Valine a steroid?
No, L-Isoleucine + L-Leucine + L-Valine is not a steroid. It is a combination of essential amino acids that are part of the branched-chain amino acids (BCAAs) group.
Does the L-Isoleucine + L-Leucine + L-Valine have any effect on mood?
Yes, the combination of L-ISOLEUCINE, L-LEUCINE, and L-VALINE may have an effect on mood as these BCAAs compete with aromatic amino acids affecting the synthesis of neurotransmitters like serotonin and dopamine which are closely linked to mood regulation.
Can L-Isoleucine + L-Leucine + L-Valine lead to weight loss?
L-Leucine, one of the components of this combination, has been shown to help manage weight by suppressing appetite. However, the overall impact on weight loss may depend on various other factors and should not be relied upon as a sole method for weight loss.
Is there any vegetarian or vegan source of L-Isoleucine + L-Leucine + L-Valine?
Yes, while BCAAs are commonly found in protein-rich foods like meat and dairy, they are also present in plant-based sources such as legumes. Therefore, vegetarians and vegans can obtain these essential amino acids from their diet.
Can I take L-Isoleucine + L-Leucine + L-Valine without consulting a doctor?
While BCAAs are generally safe, it is always best to consult with a doctor before starting any new supplement regimen, including L-Isoleucine + L-Leucine + L-Valine.
Does the L-Isoleucine + L-Leucine + L-Valine have any effect on sleep?
L-Isoleucine + L-Leucine + L-Valine is not associated with affecting sleep. However, it is always advisable to consult your doctor if you experience abnormal sleep patterns while taking this supplement.
How much time does the supplement take to work?
The absorption rate of branched-chain amino acids like these varies from person to person and depends on several factors, like metabolism and the presence of other nutrients in the body.
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