Glycerol
Uses of Glycerol
Firstly, one of the main uses of Glycerol is as an oral osmotic laxative. It is an osmotic laxative and hydrating agent.
Additionally, Glycerol is used as a topical emollient. It helps to hydrate and moisturise dry, rough, or irritated skin, including in certain skin conditions like eczema, dermatitis, and ichthyosis. Furthermore, it is used as a solvent, sweetening agent, preservative, and texturizing agent in various pharmaceutical formulations. Intravenously, it is used to manage intracranial and intraocular pressure in conditions such as glaucoma, cerebral edema, and meningitis.
Side effects of Glycerol
Headache
Nausea
Vomiting
Diarrhoea
Bloating
How Glycerol works
Glycerol is an osmotic laxative and hydrating agent.
When taken orally, it works by retaining water in the intestines. This increases the volume and pressure inside the intestines, which helps to soften the stools and stimulate bowel movements. When Glycerol is applied to the skin, it acts as a humectant, attracting water from deeper layers of the skin to the surface. It also has emollient properties that soften and soothe the skin by filling spaces between skin cells, preventing moisture loss. If Glycerol is administered intravenously, it utilises its hyperosmotic properties to shift fluid from inside body cells to outside, reducing pressure in the brain and eyes.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Glycerol can be taken orally (liquid solution, syrup or elixir), applied topically (creams, lotions, and ointments), administered intravenously (injection), rectal suppositories and enemas.
Age and Dose Restrictions
Glycerol is suitable for adults and children over the age of 2 years.
Contraindications
Glycerol should not be used by patients with known allergy to it. It is contraindicated in cases of gastrointestinal obstruction, acute abdominal pain, nausea/vomiting, and rectal bleeding. Those severely dehydrated or patients with severe renal or hepatic impairment should avoid its use. Patients with anuria or intracranial bleeding, especially subarachnoid haemorrhage, should not use Glycerol.
Other Medications to Avoid
Glycerol has no known significant interactions with other medicines. However, concurrent use of oral Glycerol might interfere with the gastrointestinal absorption of other oral medications.
Overdose and Missed Dose
Overdosing on Glycerol might cause headaches, nausea, vomiting, diarrhoea, bloating, thirst and dizziness. It is necessary to get immediate medical attention.
In case you miss a dose of Glycerol, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects like headaches, nausea, skin irritation or minor redness resolve on their own once the medication is discontinued. However, consult your doctor if symptoms persist or worsen.
Stay hydrated to help manage the side effects associated with oral or rectal use of Glycerol.
If topical use causes skin irritation, consider reducing the frequency of application.
Use in Driving and Operating Machinery
Glycerol generally does not affect your ability to drive or operate machinery unless you experience dizziness or lightheadedness.
Use in Pregnancy and Lactation
It is recommended to consult your doctor before using this medicine during pregnancy and lactation.
Caution in Other Conditions
Caution should be exercised when using Glycerol in patients with severe renal or hepatic impairment. Consultation with a doctor is advised before usage in such conditions.
Special Dietary and Lifestyle Recommendations
To manage constipation, increase your intake of dietary fibre from fruits, vegetables and whole grains.
Stay well-hydrated by drinking plenty of water throughout the day.
For dry skin conditions, avoid using harsh soaps or detergents that can strip natural oils from the skin.
Frequently asked questions
Is Glycerol safe for athletes to use?
Glycerol has been explored as a potential hydrating agent for athletes to prolong exercise endurance. However, the evidence is mixed and it is currently banned by anti-doping agencies.
Can I use Glycerol if I am diabetic?
Yes, you can use topical and rectal Glycerol even if you are diabetic. However, oral liquid Glycerol preparations may contain sugars which could affect blood glucose levels. Therefore, it is advised to consult your doctor before using oral Glycerol.
Is there any difference between Glycerol and Glycerin?
No, there is no difference between Glycerol and Glycerin. These are just different names for the same chemical compound.
What are some natural sources of Glycerol?
Glycerol naturally occurs as a component of triglycerides in animal fats and vegetable oils. It is also a byproduct of soap manufacturing and biodiesel production.
Is Glycerol safe for long-term use?
Oral or rectal Glycerol is intended for short-term use against constipation, not as a long-term solution due to potential electrolyte imbalances with prolonged use. Topical Glycerol in skincare products is safe for regular long-term use.
Can Glycerol be used for hydration during sports events?
No, Glycerol cannot be used for hydration during sports events. Even though it has been studied as a potential hydrating agent for athletes, the evidence is mixed and not strong enough to support its use in this context. In fact, it is banned by anti-doping agencies.
Is Glycerol used in personal care products?
Yes, Glycerol is frequently used in personal care products due to its ability to attract and retain moisture in the skin. It can be found in creams, lotions, and ointments to hydrate and moisturise dry or irritated skin.
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