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Glimepiride + Pioglitazone

Uses of Glimepiride + Pioglitazone

  • Glimepiride + Pioglitazone is used to manage high blood sugar levels in people with type 2 diabetes. This combination belongs to the class of antidiabetic medications.

Side effects of Glimepiride + Pioglitazone

  • Upper respiratory tract infection

  • Headache

  • Sinusitis

  • Muscle pain (myalgia)

How Glimepiride + Pioglitazone works

  • Glimepiride belongs to a class of medicines known as sulfonylureas. It works by stimulating the beta cells in the pancreas, which are responsible for making insulin, to release more insulin. Insulin helps control the level of sugar in your blood.

  • Pioglitazone is a thiazolidinedione. It makes cells (in the muscle, fat and liver) more responsive to insulin, which means they remove sugar from the blood more effectively. Together, Glimepiride and Pioglitazone work in synergy to manage blood sugar levels in people with type 2 diabetes.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Glimepiride + Pioglitazone is available for use via oral route in the form of tablets.

Age and Dose Restrictions

  • This medicine is intended for adults and children above the age of 10 years.

Contraindications

  • Glimepiride + Pioglitazone is contraindicated in patients with type 1 diabetes mellitus, severe liver impairment or heart failure of NYHA Class III or IV.

Other Medications to Avoid

  • Glimepiride + Pioglitazone may interact with other anti-diabetic medications (such as insulin, liraglutide), corticosteroids (like prednisolone, hydrocortisone), thyroid hormones (like levothyroxine, liothyronine), diuretics (like furosemide, torsemide), anticoagulants (such as warfarin, heparin) and certain antifungal medicines (like fluconazole, miconazole).

Overdose and Missed Dose

  • An overdose of Glimepiride + Pioglitazone may lead to symptoms such as hypoglycaemia (low blood sugar levels), lightheadedness, shaking, fast heartbeat, sudden sweating, or blurred vision. In case of an overdose, seek immediate medical attention.

  • If you miss a dose of Glimepiride + Pioglitazone, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Never double up on a dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • To manage common side effects like headache and sinusitis, try rest techniques.

  • Drinking plenty of fluids can help manage symptoms of upper respiratory tract infection and swelling or oedema.

Use in Driving and Operating Machinery

  • Glimepiride + Pioglitazone may cause dizziness or blurred vision. If you experience these side effects, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Glimepiride + Pioglitazone is not usually recommended for use during pregnancy or while breastfeeding. Consult your doctor before using this medication if you are pregnant, planning a pregnancy, or breastfeeding.

Caution in Other Conditions

  • Patients with congestive heart failure, liver impairment, diabetic ketoacidosis, and premenopausal anovulation should exercise caution when taking Glimepiride + Pioglitazone.

Special Dietary and Lifestyle Recommendations

  • Maintaining a balanced diet low in simple sugars and high in fibre can help manage type 2 diabetes.

  • Regular monitoring of blood glucose is essential to check the effectiveness of the medication.

Frequently asked questions

No, Glimepiride + Pioglitazone is not a steroid. It is a combination of two antidiabetic medications.

Glimepiride + pioglitazone generally don’t have a direct effect on sleep. However, individual responses can vary. If you experience sleep issues while taking these medications, consult your healthcare provider.

Glimepiride + pioglitazone typically do not affect fertility. If you have concerns or underlying conditions, it is best to consult with your healthcare provider.

Yes, it is generally safe to take Glimepiride + Pioglitazone daily as prescribed by your doctor. Regular monitoring of blood glucose and liver enzymes is necessary.

Glimepiride + pioglitazone usually starts to lower blood sugar levels within a few days to weeks of starting treatment, but it may take several weeks to see the full effect. Regular monitoring is important to assess their effectiveness.

Glimepiride + Pioglitazone should be taken once daily with your first main meal to reduce the risk of hypoglycaemia.

Glimepiride + Pioglitazone is a prescription medicine and is not available over the counter.

Terms & Conditions


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