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Glimepiride + Metformin + Voglibose

ANTIDIABETIC

Uses of Glimepiride + Metformin + Voglibose

  • Glimepiride + Metformin + Voglibose is an anti-diabetic medication used as third-line therapy for managing type 2 diabetes in adults.
  • It is recommended when blood sugar control remains inadequate despite diet, exercise, and previous treatments with one or two medications.
  • This combination helps lower both fasting and post-meal blood glucose levels, aiding in better overall glycemic control and reducing HbA1c levels for improved long-term diabetes management. It is particularly effective in minimizing post-meal blood sugar spikes.

Side effects of Glimepiride + Metformin + Voglibose

  • Nausea 
  • Diarrhoea
  • Abdominal pain
  • Constipation
  • Vomiting 
  • Metallic taste
  • Headache 
  • Dizziness

How Glimepiride + Metformin + Voglibose works

  • Glimepiride is a sulfonylurea that stimulates the pancreas to secrete more insulin. It works by closing potassium channels on the pancreatic beta cells, which leads to cell depolarization and insulin release.
  • Metformin works in several ways to control blood sugar levels. It reduces the amount of glucose produced by the liver, slows the absorption of glucose from the intestines, and makes the body's cells more sensitive to insulin, helping them take in and use glucose more effectively. Importantly, unlike sulfonylureas, metformin does not cause low blood sugar (hypoglycemia).
  • Voglibose is an alpha-glucosidase inhibitor, which means it helps control blood sugar levels by preventing the digestion of complex carbohydrates in the intestines. Normally, these carbohydrates are broken down into simple sugars and absorbed into the bloodstream. By blocking this process, Voglibose reduces the impact of carbohydrates on blood sugar levels, helping to manage diabetes. It has strong and lasting effects on various nerve-related complications associated with diabetes.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Glimepiride + Metformin + Voglibose is available for use via the oral route (tablets).

Age and Dose Restrictions

  • This combination is meant for use in adults and children above 18 years of age.

Contraindications

  • Glimepiride + Metformin + Voglibose is CONTRAINDICATED in patients with severe hepatic dysfunction, metabolic acidosis, and heart issues.

Other Medications To Avoid With This Medicine

  • The concurrent use of medications, including those prescribed for heart failure (digoxin), high blood pressure (hydrochlorothiazide, amlodipine), diuretics (furosemide), hypertension (metoprolol), steroids (prednisolone), and thyroid hormones, alongside Glimepiride + Metformin + Voglibose is not recommended. Prior consultation with a doctor is crucial before considering the use of any prescription or over-the-counter medications to ensure the safety and efficacy of the combined treatment plan.

Overdose and Missed Dose

  • Overdose of this combination can cause hypoglycemia. Inform your doctor regarding these effects and follow the advice accordingly.
  • If you forget a dose of this combination, take it as soon as you remember. But avoid repeating the dose.

Use In Driving And Operating Machinery

  • This combination does not directly impact your ability to drive or operate machinery. However, they may lead to hypoglycemia which can cause dizziness. Taking precautions to prevent low blood sugar while driving or handling machinery is essential.

Use in Pregnancy and Lactation

  • Glimepiride + Metformin + Voglibose is not recommended in pregnant and breastfeeding women.

Special Dietary & Lifestyle Recommendation

  • Making lifestyle changes, including dietary modifications and regular exercise, is essential when taking Glimepiride + Metformin + Voglibose to control blood sugar levels properly.
  • After initiating treatment with Glimepiride + Metformin + Voglibose, it's recommended to have your blood sugar levels reassessed after 15 days and, subsequently, at regular intervals every 3-6 months. This monitoring helps track the progress of the disease and allows for dose adjustments as needed.
  • If hypoglycemia occurs, it's essential to have a quick source of sugar readily available. Carry sugar candies, glucose tablets, or sugary foods and drinks without fat or protein, such as fruit juice, to promptly address low blood sugar episodes.

Frequently asked questions

This combination may start to work within a few hours, but it may take some time to see the full effects. It's important to continue taking it as your doctor prescribes, even if you start feeling better.

While taking this combination, be cautious to avoid hypoglycemia (low blood sugar). Avoid taking it if you are allergic to either of the components of this combination.

Do not stop taking this combination without consulting your doctor, even if you feel healthy. Abruptly discontinuing this medication can lead to uncontrolled blood sugar levels.

This combination typically does not affect fertility. However, if you have concerns about fertility and its impact on diabetes management, discuss them with your doctor.

Terms & Conditions


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