Glibenclamide + Metformin + Pioglitazone
Uses of Glibenclamide + Metformin + Pioglitazone
Glibenclamide + Metformin + Pioglitazone is primarily used for the management of type 2 diabetes mellitus in adult patients. It falls under the category of antidiabetic medicines.
Additionally, it serves to reduce the risk of diabetes-related complication and may lessen the likelihood of heart attack or stroke in patients with type 2 diabetes.
Side effects of Glibenclamide + Metformin + Pioglitazone
Nausea and vomiting
Diarrhoea
Weight gain
Anaemia
How Glibenclamide + Metformin + Pioglitazone works
Glibenclamide + Metformin + Pioglitazone are antidiabetic agents.
Glibenclamide belongs to the sulfonylureas group. It works by stimulating the pancreas to release more insulin, which helps in reducing blood sugar levels.
Metformin is a biguanide. It functions by decreasing the production of glucose in the liver, slowing down glucose absorption from the intestines, and enhancing the body's sensitivity to insulin.
Pioglitazone is a thiazolidinediones type of medicine. It enhances insulin sensitivity in the body's cells, allowing them to use insulin more effectively.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Glibenclamide + Metformin + Pioglitazone can be taken orally (tablets and extended-release tablets).
Age and Dose Restrictions
This combination medicine is designed for use in adults aged 18 years or over. It is not recommended for children or adolescents.
Contraindications
Glibenclamide + Metformin + Pioglitazone is contraindicated in patients with type 1 diabetes.
It is also contraindicated in patients with severe renal impairment, diabetic ketoacidosis, and those with known hypersensitivity to any of the components.
Other Medications to Avoid
Glibenclamide + Metformin + Pioglitazone may interact with antidiabetic medicines (like metformin, glyburide, insulin), thiazide diuretics (indapamide metolazone), corticosteroids (like dexamethasone, betamethasone), and sympathomimetic agents (like albuterol).
Overdose and Missed Dose
An overdose of Glibenclamide + Metformin + Pioglitazone can cause symptoms like nausea, vomiting, stomach pain, and dizziness. If this happens, immediately consult your doctor.
If a dose has been missed, it should be taken as soon as remembered. However, if it is nearly time for the next dose, skip the missed dose. Never take double doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage side effects like nausea and diarrhoea, try taking the medicine after a meal.
If you experience hypoglycemia (low blood sugar), having a small snack or glucose tablet can help.
Use in Driving and Operating Machinery
Glibenclamide + Metformin + Pioglitazone can cause dizziness and fatigue. Patients should avoid driving or operating machinery if they experience these side effects.
Use in Pregnancy and Lactation
It is recommended to consult your doctor before using Glibenclamide + Metformin + Pioglitazone during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with kidney or liver disease, congestive heart failure, alcohol abuse, and Vitamin B12 deficiency should exercise caution when taking Glibenclamide + Metformin + Pioglitazone.
Special Dietary and Lifestyle Recommendations
Managing diabetes requires a balanced diet. Limiting sugar intake and consuming whole grains, fruits, and vegetables can help control blood sugar levels.
Regular monitoring of blood sugar levels is essential to ensure the effectiveness of the medication.
Frequently asked questions
Can Glibenclamide + Metformin + Pioglitazone cause weight gain?
Yes, weight gain is a common side effect of Glibenclamide + Metformin + Pioglitazone. This is due to the ability of these medicines to increase insulin levels, which can lead to increased appetite and weight gain.
Will Glibenclamide + Metformin + Pioglitazone affect my energy levels?
Glibenclamide + Metformin + Pioglitazone may cause some patients to feel tired or weak. This is because this medicine helps to control your blood sugar levels, which might result in a decrease in energy in some people.
Is Glibenclamide + Metformin + Pioglitazone safe for long-term use?
The safety and effectiveness of long-term use of Glibenclamide + Metformin + Pioglitazone will depend on individual health conditions and the patient's response to therapy. It is important to regularly monitor your health and communicate any changes to your doctor.
Can I take Glibenclamide + Metformin + Pioglitazone if I am allergic to sulfa medicine?
Glibenclamide is a sulfonylurea, and if you are allergic to sulfa medicines, there may be a risk of allergic reaction. It is crucial to inform your doctor about any allergies before starting this medication.
Is there a specific time to take Glibenclamide + Metformin + Pioglitazone?
Yes, it is generally advised to take Glibenclamide + Metformin + Pioglitazone with meals. For specific times, it is best to consult with your doctor.
Can Glibenclamide + Metformin + Pioglitazone lead to anemia?
Yes, anemia or low red blood cell counts can be a common side effect of Glibenclamide + Metformin + Pioglitazone. Regular blood tests may be required to monitor this while you are on the medication.
Can Glibenclamide + Metformin + Pioglitazone cause hypoglycemia?
Yes, one of the common side effects of Glibenclamide + Metformin + Pioglitazone can be hypoglycemia or low blood sugar levels. It is advisable to monitor your blood sugar levels regularly when taking this medication.
Glibenclamide + Metformin + Pioglitazone in other salts
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