Glibenclamide + Metformin
Uses of Glibenclamide + Metformin
Glibenclamide + Metformin is primarily used to manage type 2 diabetes mellitus and belongs to the class of antidiabetic medications.
It is particularly useful in patients whose blood sugar levels cannot be adequately controlled by diet, exercise or a single antidiabetic medication alone. This medicine is often prescribed when lifestyle modifications such as a balanced diet and regular exercise are not sufficient to control blood sugar levels.
Side effects of Glibenclamide + Metformin
Nausea
Diarrhoea
Stomach pain
Headache
Weakness
How Glibenclamide + Metformin works
Glibenclamide falls under the category of sulfonylureas. It works by stimulating the pancreas to produce more insulin. Insulin is a hormone that helps to move glucose (sugar) from the bloodstream into cells where it is used for energy.
Metformin, on the other hand, is a biguanide. It functions by reducing the amount of glucose produced by the liver and improving insulin sensitivity in the body's cells. This ensures that more glucose is absorbed from the blood, helping to decrease high blood sugar levels.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Glibenclamide + Metformin is available in the form of tablets for oral administration.
Age and Dose Restrictions
This medicine is intended for use in adults and children above the age of 10 years.
Contraindications
This combination is contraindicated in patients with type 1 diabetes. It is also not advisable for those with severe kidney disease, liver disease, and metabolic acidosis. Patients known to have an allergy to either Glibenclamide or Metformin should avoid this medicine.
Other Medications to Avoid
Glibenclamide + Metformin may interact with diuretics (such as furosemide and torsemide), steroids (like prednisone, dexamethasone), seizure medicines (like phenytoin, phenobarbital), thyroid medicines (like levothyroxine, liothyronine), certain antibiotics (like levofloxacin, ofloxacin), antifungals (such as fluconazole, itraconazole), calcium channel blockers (like nifedipine, amlodipine), and beta-blockers (like propranolol, atenolol).
Overdose and Missed Dose
Overdosing on Glibenclamide + Metformin can result in lactic acidosis, a severe condition that requires immediate medical attention.
If one forgets to take a dose, it should be taken as soon as it is remembered unless it is nearly time for the next dose. In that case, the missed dose should be skipped, and the regular dosing schedule should continue.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience stomach upset or nausea, taking this medication with meals can help.
Consult your doctor if diarrhoea persists for a prolonged period.
Drinking plenty of fluids throughout the day can help manage dizziness and weakness.
Use in Driving and Operating Machinery
This medicine may cause dizziness or weakness, which can affect the ability to drive or operate machinery safely. Caution is advised when performing such tasks.
Use in Pregnancy and Lactation
This combination medicine should be avoided during pregnancy and breastfeeding unless recommended by a doctor.
Caution in Other Conditions
Caution should be exercised when using Glibenclamide + Metformin in patients with kidney or liver conditions.
Elderly patients may also need to exercise caution due to increased sensitivity to the medication's side effects.
Special Dietary and Lifestyle Recommendations
Regular monitoring of blood glucose levels is crucial for tracking the effectiveness of the treatment plan.
Frequently asked questions
Does Glibenclamide + Metformin cause weight gain?
No, Glibenclamide + Metformin generally does not cause weight gain. In fact, metformin is often associated with weight loss.
Can I take Glibenclamide + Metformin if I am a vegetarian or vegan?
Yes, you can. The active ingredients in this medication are synthetic and do not come from animal sources.
Will Glibenclamide + Metformin affect my mood or hormones?
While individual reactions vary, generally, this medicine does not directly affect mood or hormonal balance.
How long does Glibenclamide + Metformin stay in the body?
Both glibenclamide and metformin have relatively short half-lives, meaning they leave the body within a few hours after being taken.
What tests will my doctor monitor while I am taking Glibenclamide + Metformin?
Your doctor will likely monitor your blood glucose levels regularly to assess the effectiveness of the medication.
Are there any natural alternatives to Glibenclamide + Metformin?
It is important to note that they cannot substitute prescription medication like Glibenclamide + Metformin. Always consult your doctor before making any changes to your medication regimen.
Can I develop an allergy to Glibenclamide + Metformin?
Like any other medicine, it is possible to develop an allergic reaction to Glibenclamide + Metformin. If you experience rashes, itching, swelling, severe dizziness or difficulty breathing after taking it, seek immediate medical attention.
Glibenclamide + Metformin in other salts
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