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Gentamicin + Hydrocortisone

Uses of Gentamicin + Hydrocortisone

  • Gentamicin + Hydrocortisone is primarily used for managing bacterial infections of the eyes, ears, and skin. The combination belongs to the group of aminoglycoside antibiotics and corticosteroids.

Side effects of Gentamicin + Hydrocortisone

  • Burning or stinging sensation at the application site

  • Itching

  • Redness of treated skin or eyes

  • Dryness of treated skin or eyes

  • Temporary blurred vision (with eye drops)

How Gentamicin + Hydrocortisone works

  • Gentamicin + Hydrocortisone is an antibiotic and corticosteroid combination.

  • Gentamicin, an aminoglycoside antibiotic, works by binding to bacterial ribosomes—these are tiny machines within bacterial cells that build proteins. By disrupting this process, it causes the bacterial cells to die, thereby helping to eliminate the infection.

  • Hydrocortisone is a corticosteroid. It has potent anti-inflammatory effects, which help to reduce swelling and irritation. It does this by suppressing the immune response, reducing the dilation of small blood vessels (capillaries), and preventing the release of certain chemicals that promote inflammation.

  • Together, these components work to manage bacterial infections while simultaneously easing inflammation and discomfort.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • This combination comes in the form of topical creams and ointments for skin application, otic drops for ear infections, and eye drops or ointments for eye infections.

Age and Dose Restrictions

  • This combination can be used by both adults and children.

Contraindications

  • Gentamicin + Hydrocortisone is contraindicated in patients with known hypersensitivity to any component of the formulation.

  • It should not be used for viral infections of the eye such as herpes simplex, vaccinia, or varicella.

  • Patients with fungal infections of the eye or skin should avoid this combination.

  • It is contraindicated in patients with mycobacterial infections of the eye.

  • Those with a punctured eardrum should not use the otic drops.

Other Medications to Avoid

  • This combination may interact with ototoxic or neurotoxic medications (such as furosemide and cisplatin), other corticosteroid-containing products (like prednisolone eye drops), and medications that affect blood clotting (such as warfarin).

Overdose and Missed Dose

  • Overdose of Gentamicin + Hydrocortisone is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.

  • If a dose is missed, apply it as soon as you remember. However, if it is nearly time for the next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose.

  • In case you happen to put a few extra drops of this combination in your eye, do not panic. Rinse your eyes with clean water at room temperature. If any symptoms persist or worsen, inform your doctor.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For minor irritation at the application site, applying a cold compress may provide relief.

  • If experiencing dryness, using a simple moisturiser (free from fragrances and irritants) might help alleviate discomfort.

Use in Driving and Operating Machinery

  • Gentamicin + Hydrocortisone may cause temporary blurred vision when used as eye drops. It is advised to avoid driving or operating heavy machinery until your vision is clear.

Use in Pregnancy and Lactation

  • The safety of Gentamicin + Hydrocortisone during pregnancy and lactation has not been established. Use only if prescribed by your doctor after assessing potential risks and benefits.

Caution in Other Conditions

  • Patients with severe renal impairment need to use this combination with caution owing to the potential risk of accumulating high levels of Gentamicin, which can be toxic.

  • Those with pre-existing severe allergies should be cautious due to potential hypersensitivity reactions.

Special Dietary and Lifestyle Recommendations

  • Ensure regular hand washing to prevent spreading infection when using topical forms of this combination on infected skin areas.

  • Wear loose clothing over treated skin areas to avoid irritation and facilitate air circulation.

  • If using eye drops or ointments, ensure a hygienic application to prevent contamination and subsequent infections. Avoid touching the tip of the tube or dropper to any surface including your hands and eyes.

Frequently asked questions

The duration of treatment depends on the severity and type of infection. Your doctor will provide the best guidance.

The common side effects do not typically include sleep disturbances. However, if you experience any unusual symptoms such as insomnia, inform your doctor.

No, It is not effective against fungal infections. It is used for bacterial infections and inflammation.

There are no known effects of this combination on fertility. However, it is always recommended to consult your doctor if you are planning to conceive while using this medication.

It is best to consult your doctor before using other skin products while using combination to avoid potential interactions or adverse effects.

There is no evidence that it has any significant effect on mood or hormones. However, every individual reacts differently to medicines and if you observe any unusual changes, inform your doctor.

Even if your symptoms improve, you should continue using the combination for the full course as directed by your doctor. Stopping it early might allow the bacteria to continue growing, leading to a return of the infection.

Terms & Conditions


Available medicines for GENTAMICIN + HYDROCORTISONE
Genticyn Hc 0.3/1 % Eye Drops 5 ML
Genticyn Hc 0.3/1 % Eye Drops 5 ML
Abbott Healthcare Pvt. Ltd
Pack of 5 ML
₹9.97
MRP ₹12.16
18.00% OFF
Cortigen Eye Drops 5 ML
Cortigen Eye Drops 5 ML
Kaizen Pharma
Pack of 5 ML
₹45.10
MRP ₹55.00
18.00% OFF
Cinzy Hc 03/1 % Eye Drop 10 ML
Cinzy Hc 03/1 % Eye Drop 10 ML
Zee Laboratories Ltd
Pack of 10 ML
₹16.40
MRP ₹20.00
18.00% OFF
Genticyn Hc 0.3/1 % Eye Drops 10 ML
Genticyn Hc 0.3/1 % Eye Drops 10 ML
Abbott Healthcare Pvt. Ltd
Pack of 10 ML
₹17.73
MRP ₹21.62
18.00% OFF

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