Fenofibrate
Uses of Fenofibrate
Fenofibrate is an antilipemic agent (a lipid-regulating medicine) used to manage abnormal levels of fats in the blood.
It is also used to reduce high levels of triglycerides in adults as an addition to diet control. This can help decrease the risk of pancreatitis (inflammation of the pancreas).
Side effects of Fenofibrate
Headache
Back pain
Abdominal pain
Diarrhoea
Nausea
How Fenofibrate works
Fenofibrate is an antilipemic agent medication that helps control fat levels in the blood.
It operates by turning on a body's "switch" called peroxisome proliferator-activated receptor alpha (PPAR-α), which manages the functioning of certain genes associated with fat metabolism. This action enhances the breakdown and elimination of fat-rich particles from your blood.
In addition, Fenofibrate aids in reducing the number of harmful very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), also termed "bad" cholesterol.
It promotes an increase in beneficial high-density lipoproteins (HDL) or "good" cholesterol and also reduces the production of apolipoprotein C-III, which hampers the activity of a fat-decomposing enzyme called lipoprotein lipase.
Certified content
Written By
MD Ayurveda
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Fenofibrate can be taken orally (tablets, capsules, and delayed-release capsules).
Age and Dose Restrictions
Fenofibrate is meant for adults above the age of 18 years
Contraindications
Do not use this medicine if you have an allergy to Fenofibrate or any of its components, serious kidney problems, liver problems, including a condition called primary biliary cirrhosis, ongoing unexplained abnormal liver function, or existing gallbladder disease.
Other Medications to Avoid
This medication can interact with coumarin anticoagulants (e.g., warfarin, dicumarol), immunosuppressants (e.g., cyclosporine, tacrolimus), bile acid-binding resins (e.g., colestipol, cholestyramine), and statins (e.g., atorvastatin, simvastatin).
Overdose and Missed Dose
If you accidentally take too much Fenofibrate, you may experience symptoms such as muscle pain and tenderness, fatigue, fever, and dark urine. If this happens, consult your doctor immediately.
If you forget to take a dose of Fenofibrate, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Sipping water frequently may help in managing side effects like dry mouth or throat.
Taking Fenofibrate with meals may help in reducing gastrointestinal side effects like nausea, abdominal pain or diarrhoea.
Use in Driving and Operating Machinery
Fenofibrate does not usually affect your ability to drive or operate machinery. However, if you feel unwell or experience any side effects that could affect your ability to concentrate or react, avoid these activities until you feel better.
Use in Pregnancy and Lactation
If you are pregnant and breastfeeding, it is recommended to discuss this with your doctor before taking this medicine.
Caution in Other Conditions
If you have mild to moderate kidney problems, your doctor may need to adjust your dose of Fenofibrate. Older adults may also need dose adjustments as they are more likely to have decreased kidney function.
Special Dietary and Lifestyle Recommendations
Following a diet that is low in saturated fats and cholesterol is important when taking Fenofibrate. This will help the medicine work better at lowering your cholesterol levels.
Frequently asked questions
Can I take Fenofibrate if I am allergic to other fibrates?
No, if you are allergic to other fibrates, you should not take Fenofibrate, as you may be allergic to it as well.
How long will I need to take Fenofibrate?
Fenofibrate is usually taken long-term. The length of time you will need to take it depends on your medical condition and how well you respond to the medicine.
Can Fenofibrate cause weight gain?
Weight gain is not a common side effect of Fenofibrate. However, if you notice an unexplained weight gain, consult your doctor.
Can I stop taking Fenofibrate once my cholesterol levels improve?
No, do not stop taking Fenofibrate without consulting your doctor first. Even if your cholesterol levels have improved, you may need to continue taking the medicine to maintain this improvement.
Can I take Fenofibrate if I am allergic to peanuts or soy?
Some forms of Fenofibrate contain ingredients derived from soy and should not be taken by patients with soy allergy. If you have a peanut or soy allergy, inform your doctor before starting Fenofibrate.
Does Fenofibrate affect blood sugar levels?
Fenofibrate can sometimes affect blood sugar levels. If you have diabetes, monitor your blood sugar regularly while taking this medication.
Can Fenofibrate affect my eyesight?
In rare cases, Fenofibrate can cause eye problems. If you notice changes in your vision, contact your doctor right away.
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