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Epalrestat + Pregabalin

Uses of Epalrestat + Pregabalin

  • Epalrestat + Pregabalin is primarily used for the management of neuropathic pain, especially in patients suffering from diabetes. This combination belongs to the group of anticonvulsant and aldose reductase inhibitor medications.

  • It is also indicated for managing pain related to post-herpetic neuralgia, fibromyalgia, and neuropathic pain associated with spinal cord injury. In some instances, Pregabalin might be used as an add-on medication for treating certain types of seizures.

Side effects of Epalrestat + Pregabalin

  • Dizziness

  • Headache

  • Dry mouth

  • Nausea and vomiting

  • Swelling in hands and feet

How Epalrestat + Pregabalin works

  • Epalrestat + Pregabalin is a combination medicine for managing neuropathic pain.

  • Epalrestat is an aldose reductase inhibitor. It works by reducing the activity of an enzyme called aldose reductase. This enzyme changes excess glucose into a substance called sorbitol within nerve cells. By limiting sorbitol build-up, Epalrestat helps to prevent nerve damage and improve nerve function.

  • Pregabalin is an anticonvulsant and pain medication. It functions by attaching to specific sites on voltage-gated calcium channels in your nervous system. This action reduces the release of neurotransmitters, which are chemicals that transmit pain signals. This results in a lowered number of pain signals being sent from damaged nerves to your brain.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Epalrestat + Pregabalin is available for use orally in the form of tablets and capsules.

Age and Dose Restrictions

  • This medicine is meant for adults only.

Contraindications

  • This medicine is contraindicated in patients who are allergic to epalrestat or pregabalin.

  • It is also contraindicated in patients with end-stage kidney disease who are not receiving dialysis.

Other Medications to Avoid

  • This combination may interact with opioid pain medications (such as morphine and oxycodone), antidepressants (like duloxetine, fluoxetine, and sertraline), anti-anxiety medications (such as alprazolam), antihistamines (like cetirizine and diphenhydramine), and seizure medications (including topiramate).

Overdose and Missed Dose

  • In case of overdose, symptoms may include excessive drowsiness, confusion, and loss of consciousness. Immediate medical attention is advised to manage these symptoms effectively.

  • If you miss a dose of Epalrestat + Pregabalin, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For dizziness or drowsiness, consider taking this medication at a time when you can rest until these effects subside.

  • If experiencing dry mouth, sip water regularly or use sugar-free gum or candies to alleviate discomfort.

  • Managing nausea can be aided by taking this medicine with food or a small snack.

Use in Driving and Operating Machinery

  • Epalrestat + Pregabalin may impair your ability to drive or operate heavy machinery due to side effects like dizziness and drowsiness. It is advisable to avoid these activities if you do not feel alert.

Use in Pregnancy and Lactation

  • The safety of Epalrestat + Pregabalin during pregnancy and lactation has not been established. Consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Caution is advised when using this medication in patients with pre-existing kidney issues due to potential dose adjustments based on renal function.

  • Patients with a history of heart conditions should also proceed with caution when taking Epalrestat + Pregabalin.

Special Dietary and Lifestyle Recommendations

  • Monitor blood sugar levels regularly if you have diabetes since managing blood glucose can help reduce the risk of developing neuropathic pain.

  • Consider adopting a balanced diet rich in whole grains, vegetables, and lean proteins which might help manage symptoms related to nerve pain.

  • Staying hydrated by drinking plenty of water can help mitigate some side effects such as dry mouth caused by this medication.

  • Engage in light to moderate physical activities such as walking or swimming, which may enhance overall nerve health and help in reducing neuropathic pain symptoms.

  • Practice stress-reducing techniques such as yoga or meditation to help manage the psychological impact of chronic pain conditions.

Frequently asked questions

If you are allergic to either Epalrestat or Pregabalin or any other ingredients in this combination, you should inform your doctor about it.

There is no effect of Epalrestat + Pregabalin on fertility.

Yes, Epalrestat + Pregabalin can be used in managing post-herpetic neuralgia, a type of neuropathic pain that can occur after a shingles infection.

Epalrestat + Pregabalin may cause some changes in mood or emotions in certain individuals. However, these effects vary from person to person. Consult your doctor for more information.

Epalrestat + Pregabalin is not typically associated with addiction or dependency. However, it should always be used under the supervision of a doctor.

There are no specific food items that you need to avoid while taking Epalrestat + Pregabalin unless advised by your doctor.

The time it takes for Epalrestat + Pregabalin to start working will depend on various factors including the condition being treated and individual patient factors. Always consult with your doctor for more information.

Terms & Conditions


Available medicines for EPALRESTAT + PREGABALIN
Pre Aldonil 75 Tablet 10
Pre Aldonil 75 Tablet 10
Zydus Cadila
Pack of 10 Units
₹435.95
MRP ₹531.65
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Pre Aldonil Od Tablet 10
Pre Aldonil Od Tablet 10
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₹204.18
MRP ₹249.00
18.00% OFF
Alrista Forte 150/150 MG Tablet 10
Alrista Forte 150/150 MG Tablet 10
Macleods Pharmaceuticals Pvt.ltd
Pack of 10 Units
₹171.38
MRP ₹209.00
18.00% OFF
Pre Aldonil 150/150 MG Tablet 10
Pre Aldonil 150/150 MG Tablet 10
Zydus Cadila
Pack of 10 Units
₹435.95
MRP ₹531.65
18.00% OFF

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