Doxofylline + Montelukast
Uses of Doxofylline + Montelukast
Doxofylline + Montelukast is primarily used for the prophylaxis and chronic management of asthma and as an add-on therapy for symptomatic relief in patients with chronic obstructive pulmonary disease (COPD). It belongs to the group of bronchodilators and leukotriene receptor antagonists.
It is also used to prevent exercise-induced bronchoconstriction and relieve symptoms of both seasonal and perennial allergic rhinitis.
Side effects of Doxofylline + Montelukast
Headache
Nausea, vomiting, diarrhoea and abdominal pain
Dizziness
Fatigue
Allergic reactions such as rash, urticaria, angioedema
How Doxofylline + Montelukast works
Doxofylline belongs to a group of medicines known as xanthine derivatives. It works by inhibiting specific enzymes known as phosphodiesterases in our bodies. This action relaxes the muscles surrounding the airways, making breathing easier and reducing the cough.
Montelukast is a leukotriene receptor antagonist. It works by blocking the action of leukotriene D4 (LTD4), a natural substance that causes inflammation, constriction of airways, and production of mucus in the lungs. This results in an ease of breathing and a reduction in symptoms.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Doxofylline + Montelukast is available in (tablet) formulation for oral administration.
Age and Dose Restrictions
Doxofylline + Montelukast combination medication is suitable for adults and children aged 12 months and older.
Contraindications
This medicine is contraindicated for patients with known hypersensitivity to either doxofylline, montelukast or any other inactive ingredient present in the formulation.
Other Medications to Avoid
Doxofylline + Montelukast can interact with xanthines (such as theophylline, aminophylline), H2 receptor antagonists (such as cimetidine, ranitidine), and antibiotics (like erythromycin, clarithromycin).
Overdose and Missed Dose
Overdose of this medicine may cause symptoms like nausea, vomiting, and headache. In case of a suspected overdose, contact your doctor immediately.
If you miss a dose of this medicine, take it as soon as you remember. However, if it is close to your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids may help in managing gastrointestinal disturbances like nausea and vomiting.
Resting or lying down can help manage dizziness or fatigue.
Use in Driving and Operating Machinery
This combination of medications may cause drowsiness or dizziness. If you experience these side effects, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
It is advised to consult your doctor before using this medication during pregnancy and lactation, as safety in such cases has not been fully established.
Caution in Other Conditions
Caution should be exercised when using this medication in patients with peptic ulcer disease, hepatic impairment, and cardiovascular disorders.
Special Dietary and Lifestyle Recommendations
Regular physical activity can help improve lung capacity, thereby managing conditions like asthma and COPD.
Avoid exposure to allergens and pollutants that may trigger respiratory symptoms.
Maintain a balanced diet to keep your immune system healthy and prevent any nutritional deficiencies.
Smoking cessation is highly recommended as smoke can aggravate respiratory conditions.
Frequently asked questions
Does taking Doxofylline + Montelukast have any effect on sleep?
In some cases, individuals taking Doxofylline + Montelukast may experience insomnia as a side effect. Always consult your doctor for any sleep disturbances while on this medication.
Can Doxofylline + Montelukast affect fertility?
There is not enough scientific evidence to suggest that Doxofylline + Montelukast has an impact on fertility. If you are planning a family or if you have concerns, you should consult your doctor.
How long does it take for Doxofylline + Montelukast to start working?
Doxofylline and Montelukast are rapidly absorbed after oral administration, and their peak effects can usually be felt within a few hours.
Are there any natural alternatives to Doxofylline + Montelukast?
While some natural remedies may help manage symptoms of asthma and other respiratory conditions, they should not replace prescribed medications like Doxofylline + Montelukast without consultation from your doctor.
How long does Doxofylline + Montelukast stay in your system?
Doxofylline has a half-life of about 6 to 8 hours, meaning it stays in your system for roughly 30 to 40 hours before being mostly cleared. Montelukast has a half-life of approximately 2.7 to 5.5 hours, so it generally stays in your system for about 13 to 27 hours.
Will Doxofylline + Montelukast affect my mood?
Neuropsychiatric events such as agitation, aggression, depression, and suicidal thoughts or behaviour may occur in rare cases. If you experience any changes in mood or behaviour while taking this medication, seek immediate medical attention.
Is Doxofylline + Montelukast an over-the-counter medicine, or do I need a prescription?
Doxofylline + Montelukast usually requires a doctor's prescription and is not available over the counter
Doxofylline + Montelukast in other salts
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