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Desloratadine + Montelukast

Uses of Desloratadine + Montelukast

  • Desloratadine + Montelukast is primarily used to manage symptoms of seasonal allergic rhinitis (hay fever) and urticaria (skin allergies).
  • Desloratadine, an antihistamine, helps relieve sneezing, runny nose, itchy eyes, and nasal congestion, while Montelukast, a leukotriene receptor antagonist, reduces inflammation by blocking leukotrienes, providing relief from difficulty breathing.
  • Together, they offer quick relief from allergic symptoms like coughing, watery eyes, and swelling.

Side effects of Desloratadine + Montelukast

  • Headache

  • Fatigue

  • Drowsiness

  • Dry mouth

  • Nausea

How Desloratadine + Montelukast works

  • Desloratadine belongs to the antihistamines class of medicines. It works by selectively blocking histamine H1 receptors. Histamine is a chemical in the body that triggers allergic reactions. By inhibiting these receptors, Desloratadine reduces the effects of histamine, providing relief from symptoms such as sneezing, runny nose, and itchy or watery eyes.
  • Montelukast is a leukotriene receptor antagonist. It works by blocking a substance called leukotriene D4 from attaching to its receptor in the lungs and airways. This helps to reduce inflammation, prevent the airways from narrowing, and decrease mucus production. As a result, Montelukast effectively relieves both nasal and bronchial symptoms of allergic rhinitis (hay fever).

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Desloratadine + Montelukast is available in tablet form for oral administration.

Age and Dose Restrictions

  • This medicine is meant for adults and adolescents above 15 years of age.

Contraindications

  • Desloratadine + Montelukast is contraindicated in patients with known hypersensitivity to desloratadine, loratadine, montelukast, or any of the other ingredients in the formulation.

  • It is also contraindicated in patients with severe liver impairment and severe kidney impairment.

Other Medications to Avoid

  • This medicine can interact with macrolide antibiotics (such as erythromycin), antifungals (such as ketoconazole), CYP3A4 inducers (such as phenytoin or rifampin), antihistamines (such as diphenhydramine) and CNS depressants (such as diazepam).

Overdose and Missed Dose

  • An overdose of Desloratadine + Montelukast may cause severe drowsiness. In such a case, seek immediate medical attention.

  • If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not take two doses at once.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Nonetheless, if you experience any side effects, try taking the medicine with food or at bedtime.

  • Drinking plenty of water may also help to alleviate dry mouth.

Use in Driving and Operating Machinery

  • Desloratadine + Montelukast can cause drowsiness and dizziness. If you experience these side effects, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Consult your doctor before using this medicine during pregnancy or if you are breastfeeding.

Caution in Other Conditions

  • Patients with a history of mental health disorders should use Desloratadine + Montelukast with caution.

  • Elderly patients should also use it cautiously as they may have reduced kidney function.

Special Dietary and Lifestyle Recommendations

  • Avoid potential allergens, such as dust and pollen, as much as possible.

  • Keep windows closed during high pollen seasons.

  • Wash your hands frequently to decrease the chance of contaminating your eyes or nose with allergens.

  • Use air purifiers to reduce indoor allergens.

Frequently asked questions

Desloratadine + Montelukast can affect behaviour or mood. If you notice any unusual mood or behaviour changes while taking this medication, seek immediate medical attention.

Desloratadine + Montelukast may cause sleepiness or somnolence. If this happens, you should consult your doctor.

No, Desloratadine + Montelukast is not a steroid. It is a combination of an antihistamine (Desloratadine) and a leukotriene receptor antagonist (Montelukast).

Yes, Desloratadine + Montelukast can be taken for long-term use. However, it should be taken only as per the doctor's prescription and direction.

Some relief from allergy symptoms may be observed within an hour of taking Desloratadine + Montelukast. However, the maximum effectiveness may take several days of regular dosing.

Desloratadine + Montelukast is not directly associated with affecting fertility. However, if you have concerns about fertility, it would be best to consult with your doctor.

No, Desloratadine + Montelukast is not available over the counter. It requires a prescription from a doctor.

Terms & Conditions


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