Dapagliflozin + Metformin + Sitagliptin
Uses of Dapagliflozin + Metformin + Sitagliptin
Dapagliflozin + Metformin + Sitagliptin is predominantly used to manage type 2 diabetes mellitus in adults and belongs to the group of antidiabetic medications.
This combination may also be used in circumstances where blood sugar is not adequately controlled by metformin alone or by metformin in combination with either sitagliptin or dapagliflozin.
Side effects of Dapagliflozin + Metformin + Sitagliptin
Genital fungal infections
Common cold symptoms (nasopharyngitis)
Urinary tract infections
Diarrhoea
Nausea
How Dapagliflozin + Metformin + Sitagliptin works
Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose (sugar) in the kidneys, leading to more sugar being passed out in urine, thereby reducing blood sugar levels.
Metformin is a biguanide. It acts by reducing the amount of glucose your liver produces and your intestines absorb. It also increases the body's response to insulin, which is a hormone that controls the distribution of sugar in the body.
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of insulin produced by your body and reduces the amount of glucose made by your liver. Together, these medications work to manage blood sugar levels effectively in adults with type 2 diabetes.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Dapagliflozin + Metformin + Sitagliptin can be taken orally (tablet).
Age and Dose Restrictions
This combination medication is specifically meant for adults to manage their type 2 diabetes condition.
Contraindications
Dapagliflozin + Metformin + Sitagliptin is contraindicated in patients with type 1 diabetes. It should not be used by people with severe kidney impairment or individuals who have a known hypersensitivity to any of the active ingredients in this combination.
Other Medications to Avoid
This combination may interact with insulin and insulin secretagogues (such as glipizide, and glyburide), and diuretics (like hydrochlorothiazide, and furosemide).
Overdose and Missed Dose
An overdose of this combination could lead to symptoms such as confusion, vomiting, or abdominal pain. If you suspect an overdose, inform your doctor immediately.
If you miss a dose, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed one. Do not double up on doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage digestive issues like diarrhoea or nausea, try taking this medicine with food.
For prevention of genital fungal infections, maintain good personal hygiene.
Stay well-hydrated to reduce the risk of urinary tract infections and to ensure kidney health.
Use in Driving and Operating Machinery
Dapagliflozin + Metformin + Sitagliptin may cause dizziness or fatigue. If you experience these side effects, avoid driving and operating heavy machinery until you feel alert again.
Use in Pregnancy and Lactation
The use of this combination medicine during pregnancy or while breastfeeding should only be done under the guidance of your doctor. It is advised to consult your doctor before taking this medication in these conditions.
Caution in Other Conditions
Patients with liver disease, heart failure, or pancreatic disorders should exercise caution when taking Dapagliflozin + Metformin + Sitagliptin. Always inform your doctor about any existing medical conditions before beginning this medication.
Special Dietary and Lifestyle Recommendations
Regularly monitor your blood sugar levels to maintain optimal control over diabetes.
Limit consumption of processed foods, sweets, and sugary drinks.
Frequently asked questions
Can Dapagliflozin + Metformin + Sitagliptin cause weight loss?
Dapagliflozin, one of the components of this combination, may cause some weight loss by increasing glucose excretion in the urine. However, weight loss is not the primary function of this medicine and any significant weight changes should be reported to your doctor.
Can I stop taking Dapagliflozin + Metformin + Sitagliptin if my blood sugar levels are controlled?
No, you should not stop taking Dapagliflozin + Metformin + Sitagliptin without consulting your doctor first. Even if your blood sugar levels are controlled, stopping the medicine abruptly may lead to hyperglycaemia (high blood sugar).
Can I take Dapagliflozin + Metformin + Sitagliptin while fasting?
Always consult your doctor before fasting or making any significant changes to your eating habits while taking Dapagliflozin + Metformin + Sitagliptin.
Is Dapagliflozin + Metformin + Sitagliptin safe for long-term use?
The safety of long-term use of Dapagliflozin + Metformin + Sitagliptin will depend on your individual health circumstances and should be assessed by your doctor.
Is there a risk of becoming dependent on Dapagliflozin + Metformin + Sitagliptin?
There's no evidence to suggest that patients become physically or psychologically dependent on this medication.
Can I take Dapagliflozin + Metformin + Sitagliptin without a doctor's recommendation?
No, it is essential to consult your doctor before starting any new medication. Dapagliflozin + Metformin + Sitagliptin is typically prescribed when blood sugar levels are not adequately managed by metformin alone or in combination with either dapagliflozin or sitagliptin.
Are there any natural alternatives to Dapagliflozin + Metformin + Sitagliptin?
While some lifestyle changes like a balanced diet and regular exercise can help manage diabetes, they cannot replace the effect of prescribed medication like Dapagliflozin + Metformin + Sitagliptin. Always consult your doctor before stopping any medication or starting any natural alternatives.
Dapagliflozin + Metformin + Sitagliptin in other salts
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