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Clobetasol + Gentamicin

Uses of Clobetasol + Gentamicin

  • Clobetasol + Gentamicin is used to treat skin infections caused by bacteria and manage inflammatory skin conditions prone to such infections.
  • This combination includes Clobetasol, a potent corticosteroid that reduces inflammation and redness, and Gentamicin, an antibiotic that inhibits bacterial protein synthesis.
  • It is also effective for conditions like eczema, atopic dermatitis, psoriasis, contact dermatitis, seborrheic dermatitis, lichen simplex chronicus, discoid lupus erythematosus, and lichen planus, addressing both infections and inflammation in various dermatological conditions.

Side effects of Clobetasol + Gentamicin

  • Burning or stinging sensation at the application site

  • Skin dryness or cracking

  • Irritation at the application site

  • Hypopigmentation of skin

  • Folliculitis

How Clobetasol + Gentamicin works

  • Clobetasol + Gentamicin is a combination of a potent topical corticosteroid and an aminoglycoside antibiotic.

  • Clobetasol, the corticosteroid component, reduces inflammation and itching. It does this by decreasing the production of inflammatory chemicals in the skin, suppressing the immune response that leads to inflammation, and constricting blood vessels to reduce redness and swelling.

  • The antibiotic component, Gentamicin, prevents or manages bacterial skin infections. It does this by binding to bacterial ribosomes to inhibit protein synthesis, changing cell membrane permeability, and causing misreading of mRNA leading to faulty protein synthesis. This hampers bacterial growth and replication, leading to bacterial cell death. Together, these components manage inflammatory skin conditions susceptible to bacterial infections.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Clobetasol + Gentamicin is available as a topical cream, ointment, lotion, and gel. These formulations are to be applied directly to the affected skin areas.

Age and Dose Restrictions

  • This medication is meant for use by both adults and children, though caution is advised when it is used on younger patients due to increased absorption rates that could lead to higher systemic effects.

Contraindications

  • Clobetasol + Gentamicin is contraindicated in patients with hypersensitivity to clobetasol, gentamicin, or any of the excipients.

  • It should not be used by individuals with skin infections caused by fungi, viruses, or mycobacteria.

  • Other contraindications include conditions like acne rosacea and perioral dermatitis.

Other Medications to Avoid

  • This combination may interact with NSAIDs (such as ibuprofen and naproxen), CYP3A4 inhibitors (like itraconazole and ritonavir), neuromuscular blocking agents (such as vecuronium and rocuronium), and diuretics (like furosemide).

Overdose and Missed Dose

  • An overdose of Clobetasol + Gentamicin might result in excessive redness, peeling, and discomfort at the application site. In such instances, wash the area thoroughly with water and discontinue use until speaking with a doctor.

  • If you forget to apply Clobetasol + Gentamicin at the scheduled time, apply it as soon as you remember unless it is close to the time of your next dose. Do not apply more than what is recommended in an attempt to make up for the missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage skin dryness or irritation, consider applying a gentle moisturiser around the area treated with Clobetasol + Gentamicin but not directly mixed with the medication.

  • If burning or stinging occurs upon application, ensure that the skin is clean and dry before applying; sometimes moisture trapped under the medication can increase discomfort.

Use in Driving and Operating Machinery

  • As a topical medication, Clobetasol + Gentamicin does not impact the ability to drive or operate heavy machinery.

Use in Pregnancy and Lactation

  • Clobetasol + Gentamicin falls under Category C for use during pregnancy. It should only be used when needed and under direct advice from a doctor.

  • For breastfeeding mothers, it may be used with caution. Ensure that the treatment area does not come into direct contact with the infant.

Caution in Other Conditions

  • Patients who have diabetes need to monitor their blood glucose levels closely because corticosteroids including Clobetasol can affect blood sugar control.

  • Continuous long-term use should be monitored for effects like thinning of the skin or adrenal suppression.

Special Dietary and Lifestyle Recommendations

  • Maintain good hygiene around affected skin areas to support recovery from dermatological conditions treated by Clobetasol + Gentamicin.

  • Wear loose-fitting clothing over affected areas to prevent irritation from rubbing or excessive sweating.

  • Consider using hypoallergenic products on your skin such as soaps and laundry detergents to avoid further irritation.

  • Keep hydrated by drinking plenty of water daily which can help maintain skin hydration overall.

Frequently asked questions

Yes, Clobetasol in the combination of Clobetasol + Gentamicin is a potent corticosteroid. It helps in reducing inflammation, redness, and swelling.

No, Clobetasol + Gentamicin is not recommended for treating fungal skin infections. The antibiotic component, Gentamicin, is effective against certain types of bacteria but does not work against fungi.

It is generally advised to avoid using Clobetasol + Gentamicin on the face unless specifically instructed by your doctor. The skin on the face is more delicate and may react differently to this medication.

Children can use Clobetasol + Gentamicin under medical supervision, but caution should be exercised as they are more prone to systemic absorption and adrenal suppression.

There is no recognized risk of dependency or addiction associated with the use of Clobetasol + Gentamicin. However, long-term use should be avoided due to possible side effects.

It is not advisable to abruptly discontinue use of Clobetasol + Gentamicin after prolonged use as it may lead to steroid withdrawal symptoms. Always consult your doctor for advice on stopping this medication.

Patients with diabetes should exercise caution while using Clobetasol + Gentamicin as it may affect blood glucose control. Regular monitoring of blood glucose levels is recommended.

Terms & Conditions


Clobetasol + Gentamicin in other salts

CLOBETASOL PROPIONATE + MICONAZOLE + NEOMYCINCLOBETASOL PROPIONATE + SALICYLIC ACIDOFLOXACIN + ORNIDAZOLE + ITRACONAZOLE + CLOBETASOLCLOBETASOLCLOBETASOL + CLOTRIMAZOLE + NEOMYCINCLOBETASOL PROPIONATE + OFLOXACIN + ORNIDAZOLE + TERBINAFINEBETAMETHASONE + GENTAMICINCLOBETASOL PROPIONATECLOBETASONE + GENTAMICINBETAMETHASONE + GENTAMICIN + MICONAZOLECLOBETASOL PROPIONATE + GENTAMICIN + MICONAZOLEBETAMETHASONE + CLOTRIMAZOLE + GENTAMICINBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLE + GENTAMICINCLOBETASOL PROPIONATE + NEOMYCINCLOBETASOL PROPIONATE + GENTAMICINCLOBETASOL PROPIONATE + MICONAZOLECLOBETASOL PROPIONATE + FUSIDIC ACIDGENTAMICINCLOBETASONE + GENTAMICIN + MICONAZOLECHLORHEXIDINE GLUCONATE + CLOBETASOL PROPIONATE + MICONAZOLE + NEOMYCINCLOBETASOL PROPIONATE + IODOCHLORHYDROXYQUINOLINE + KETOCONAZOLE + NEOMYCIN + TOLNAFTATECLOBETASOL PROPIONATE + LACTIC ACID + SALICYLIC ACID + UREACIPROFLOXACIN + CLOBETASOL PROPIONATE + METRONIDAZOLE + TERBINAFINECLOBETASOL PROPIONATE + CLOTRIMAZOLE + FUSIDIC ACIDBETAMETHASONE + CLIOQUINOL + GENTAMICIN + TOLNAFTATECHLOROCRESOL + CLOBETASOL PROPIONATE + MICONAZOLE + NEOMYCINCLOBETASOL PROPIONATE + ITRACONAZOLE + OFLOXACIN + ORNIDAZOLECLOBETASOL + MICONAZOLE + NEOMYCINCLOBETASOL + NADIFLOXACINCLIOQUINOL / IODOCHLORHYDROXYQUINOLINE + CLOBETASOL PROPIONATE + CLOTRIMAZOLE + GENTAMICIN + TOLNAFTATECLOBETASOL + SALICYLIC ACIDCLOBETASOL PROPIONATE + MICONAZOLE + NEOMYCIN + ZINC SULPHATE MONOHYDRATECLOBETASOL + GENTAMICIN + MICONAZOLECHLOROCRESOL + CLOBETASOL + MICONAZOLE + NEOMYCINCLOBETASOL + OFLOXACIN + ORNIDAZOLE + TERBINAFINEDEXAMETHASONE + GENTAMICINBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLE + GENTAMICIN + LIDOCAINE / LIGNOCAINEGENTAMICIN + HYDROCORTISONEAMMONIUM LACTATE + CLOBETASOL PROPIONATECALCIPOTRIOL + CLOBETASOL PROPIONATECLOBETASOL PROPIONATE + COAL TAR + SALICYLIC ACID
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