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Clindamycin + Clotrimazole

ANTIBIOTIC/ANTIFUNGAL

Uses of Clindamycin + Clotrimazole

  • Clindamycin + Clotrimazole is a combination of antibiotic and antifungal agents used to treat vaginal infections, including bacterial vaginosis, yeast infections (candidiasis), and parasitic infections (trichomoniasis). This combination effectively manages bacterial, fungal, and parasitic infections in the vaginal area.

Side effects of Clindamycin + Clotrimazole

  • Burning sensation
  • Irritation
  • Itching

How Clindamycin + Clotrimazole works

  • Clindamycin is an antibacterial agent. It inhibits bacterial growth by binding to the bacterial ribosome, disrupting protein synthesis and ultimately killing or inhibiting the growth of susceptible bacteria. It is effective against a wide range of Gram-positive aerobic and anaerobic bacteria.
  • Clotrimazole is an antifungal agent. It disrupts the synthesis of ergosterol, an essential component of the fungal cell membrane. By interfering with ergosterol production, Clotrimazole weakens the fungal cell wall, leading to the death of the fungus. 

Certified content

Written By

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Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Clindamycin + Clotrimazole is available via the vaginal route (gel and suppository).

Age And Dose Restrictions

  • This combination should be used by adults only. 

Contraindications 

  • Clindamycin + Clotrimazole is contraindicated in patients who are hypersensitive to Clindamycin or Clotrimazole.

Medications To Avoid With This Drug 

  • Avoid taking neuromuscular blocking agents and immunosuppressive medications (Tacrolimus) with this combination.

Overdose And Missed Dose

  • There is no risk of overdosage as it is for intravaginal application only. However, if this medicine is ingested accidentally, then visit the hospital immediately.
  • If you miss a dose of Clindamycin + Clotrimazole, use it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management of side effects 

  • The side effects of this combination are temporary and resolve on discontinuation. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • It is unlikely to impair the mental alertness or coordination required while driving.

Use In Pregnancy And Lactation

  • Caution is advised for the use of Clindamycin + Clotrimazole in pregnant and breastfeeding women.

Caution In Other Conditions

  • It should also be cautiously by those experiencing irregular vaginal bleeding, abnormal vaginal bleeding or a blood-stained discharge, vulval or vaginal ulcers, blisters or sores, lower abdominal pain or dysuria, any adverse events such as redness, irritation or swelling associated with the treatment, fever or chills, nausea or vomiting, diarrhoea, and foul-smelling vaginal discharge.
  • It should also be cautiously administered in older women as the vaginal tissues of older women may be more delicate and prone to dryness. 

Special Dietary And Lifestyle Recommendation

  • Do not use it during menstruation.
  • Avoid engaging in vaginal intercourse or use of other vaginal products (such as tampons or douches) during treatment with this combination.
  • Practice hygiene by washing the external genital area with mild, unscented soap and water. Avoid douching, as it disrupts the natural balance of the vaginal flora and can increase the risk of infections.
  • Avoid scented products, including soaps, detergents, feminine hygiene sprays, and scented products. These can irritate the delicate vaginal tissues and disrupt the natural pH balance.

Frequently asked questions

Clindamycin + Clotrimazole may improve the symptoms in 1-3 days after using it.

Do not stop Clindamycin + Clotrimazole early; use it till the prescribed duration to ensure the infection is fully treated.

Clindamycin + Clotrimazole is not habit-forming and is generally safe when used as directed.

There is limited information available on the effect of Clindamycin + Clotrimazole on fertility. However, if you are concerned about the effect of this medicine on fertility, consult your doctor for personalised advice.

Clindamycin + Clotrimazole usually requires a prescription and is unavailable over the counter.

To use vaginal suppository, wash your hands thoroughly before handling the suppository. Lie down on your back with your knees bent or stand with one foot elevated on a chair. Now, gently insert and push the suppository into the vagina using the applicator provided or your finger. Wash your hands again after insertion. 

Terms & Conditions


Clindamycin + Clotrimazole in other salts

CLOTRIMAZOLEADAPALENE + CLINDAMYCINCLINDAMYCIN + NICOTINAMIDECLINDAMYCINBECLOMETASONE + NEOMYCIN + CLOTRIMAZOLECLOBETASOL + CLOTRIMAZOLE + NEOMYCINCLINDAMYCIN + CLOTRIMAZOLE + TINIDAZOLECLINDAMYCIN + CLOTRIMAZOLE + METRONIDAZOLEBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLEBENZOYL PEROXIDE + CLINDAMYCINCLINDAMYCIN + ISOTRETINOINBETAMETHASONE + CLOTRIMAZOLEBETAMETHASONE + CLOTRIMAZOLE + GENTAMICINCLOTRIMAZOLE + FLUOCINOLONE + NEOMYCINBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLE + GENTAMICINCIPROFLOXACIN + CLOTRIMAZOLE + FLUOCINOLONEBECLOMETASONE + CLOTRIMAZOLE + NEOMYCINCLOTRIMAZOLE + FUSIDIC ACID + MOMETASONECLOTRIMAZOLE + MOMETASONECLOBETASOL PROPIONATE + CLOTRIMAZOLE + FUSIDIC ACIDBETAMETHASONE + CLOTRIMAZOLE + NEOMYCINCLIOQUINOL / IODOCHLORHYDROXYQUINOLINE + CLOBETASOL PROPIONATE + CLOTRIMAZOLE + GENTAMICIN + TOLNAFTATECLOTRIMAZOLE + LIDOCAINE / LIGNOCAINEBETAMETHASONE + CLINDAMYCIN + NICOTINAMIDEBECLOMETASONE + CLOTRIMAZOLEBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLE + LIDOCAINE / LIGNOCAINE + OFLOXACINBECLOMETHASONE DIPROPIONATE + CHLORAMPHENICOL + CLOTRIMAZOLEBECLOMETHASONE DIPROPIONATE + CHLORAMPHENICOL + CLOTRIMAZOLE + LIDOCAINE / LIGNOCAINEALLANTOIN + CLOTRIMAZOLEBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLE + LIDOCAINE / LIGNOCAINE + NEOMYCINBECLOMETHASONE DIPROPIONATE + CLOTRIMAZOLE + GENTAMICIN + LIDOCAINE / LIGNOCAINECLINDAMYCIN + TRETINOINALLANTOIN + CLINDAMYCIN + NICOTINAMIDECLOTRIMAZOLE + TINIDAZOLECLOTRIMAZOLE + LACTOBACILLUS + TINIDAZOLE
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