Cefoperazone
Uses of Cefoperazone
Cefoperazone is primarily used to manage a variety of bacterial infections. It belongs to the class of third-generation cephalosporin antibiotics.
It is also indicated for managing respiratory tract infections, peritonitis and other intra-abdominal infections, bacterial septicemia, skin and skin structure infections, pelvic inflammatory disease, endometritis, and other infections of the female genital tract, urinary tract infections, and bone and joint infections.
Side effects of Cefoperazone
Diarrhoea
Nausea and vomiting
Abdominal pain
Rash, pruritus (itching), urticaria (hives)
Temporary increase in liver enzymes
How Cefoperazone works
Cefoperazone is a third-generation cephalosporin antibiotic.
This medicine works by inhibiting the synthesis of bacterial cell walls. It does so by binding to and disabling specific proteins known as penicillin-binding proteins (PBPs), which are located within the bacterial cell wall.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
- Cefoperazone is available in injection form for intravenous administration.
Age and Dose Restrictions
- Cefoperazone is meant for use in adults and paediatric patients.
Contraindications
- Cefoperazone is contraindicated in individuals who have a known hypersensitivity to it or any other cephalosporin antibiotics.
- It should not be used in patients who have had an anaphylactic reaction to penicillin, as cross-reactivity may occur.
Other Medications to Avoid
- This medicine may interact with anticoagulants (such as warfarin), and aminoglycoside antibiotics (such as gentamicin).
Overdose and Missed Dose
- An overdose of Cefoperazone may result in symptoms like seizures, severe vomiting, and diarrhoea. In such a scenario, immediate medical attention is required.
- If you miss a dose of Cefoperazone, contact your healthcare provider immediately for instructions. Do not double up on doses to compensate for the missed one.
Management of Side Effects
Most side effects are temporary, generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- To manage nausea and vomiting, try taking this medicine with food or milk.
- Drinking plenty of fluids may help to alleviate some of the gastrointestinal side effects, like diarrhoea.
Use in Driving and Operating Machinery
- Cefoperazone may cause dizziness or drowsiness. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough to perform these activities safely.
Use in Pregnancy and Lactation
- Cefoperazone is not recommended for use during pregnancy and breastfeeding unless necessary. Consult your doctor before using this medication during pregnancy and lactation.
Caution in Other Conditions
- Cefoperazone should be administered with caution in patients with impaired renal function, as it is primarily excreted by the kidney.
- Dosage adjustment may be necessary for patients with hepatic dysfunction and those with both renal and hepatic insufficiencies.
Special Dietary and Lifestyle Recommendations
- Maintain proper hygiene to prevent the spread of bacterial infections.
- Rest and get enough sleep to help your body recover from an infection.
Frequently asked questions
Does Cefoperazone affect mood or cause drowsiness?
Cefoperazone does not have any impact on mood or cause drowsiness. However, as with any medication, individual reactions may vary, and it is always best to consult your doctor if you experience any unexpected side effects.
Does Cefoperazone have an impact on menstruation?
Cefoperazone does not directly affect menstruation. However, if you notice any irregularities in your menstrual cycle while administering this medicine, it is recommended to consult your doctor.
Can Cefoperazone be used for treating viral infections?
No, Cefoperazone is an antibiotic, which means it is effective against bacterial infections. It does not work against viruses.
Is Cefoperazone habit-forming?
No, Cefoperazone is not habit-forming or causes dependency.
Is Cefoperazone available over the counter, or do I need a prescription?
Cefoperazone is a prescription medicine and is not available over the counter.
How is Cefoperazone administered?
Cefoperazone is administered parenterally, which means it is given through an injection or intravenous infusion. It cannot be taken orally.
How quickly does Cefoperazone start working?
After intravenous administration, therapeutic serum levels of Cefoperazone are attained immediately. However, the time it takes for symptoms to improve will depend on the type and severity of the infection.
Cefoperazone in other salts
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