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Cefepime + Sulbactam

Uses of Cefepime + Sulbactam

  • Cefepime + Sulbactam is primarily used to manage a variety of serious bacterial infections and belongs to the group of antibiotics.

  • It is also used in empiric therapy for febrile neutropenic patients and complicated intra-abdominal infections (in combination with metronidazole).

Side effects of Cefepime + Sulbactam

  • Diarrhoea

  • Nausea and Vomiting

  • Abdominal pain

  • Headache

  • Injection Site Reactions

How Cefepime + Sulbactam works

  • Cefepime + Sulbactam is an antibiotic combination.

  • Cefepime is a fourth-generation cephalosporin. It operates by arresting the synthesis of the bacterial cell wall. It sticks to proteins in the bacterial cell wall, disrupting the construction of a critical molecule called peptidoglycan, leading to the bursting and death of the bacteria.

  • Sulbactam is a beta-lactamase inhibitor. It works by stopping beta-lactamases, which are bacterial enzymes that break down antibiotics like cefepime. By preventing this breakdown, sulbactam extends the effectiveness of cefepime to fight off bacteria even if they produce beta-lactamases.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Cefepime + Sulbactam is available as a sterile powder for reconstitution, specifically designed for injection.

  • This medicine is administered either by intravenous infusion or deep intramuscular injection, which allows the medicine to enter the bloodstream directly and act quickly against infections.

Age and Dose Restrictions

  • Cefepime + Sulbactam is meant for use in adult patients.

Contraindications

  • Cefepime + Sulbactam is contraindicated in patients with known serious hypersensitivity to cefepime, sulbactam, or other beta-lactam antibiotics.

  • It is also contraindicated in individuals who have had severe allergic reactions to penicillin antibiotics.

Other Medications to Avoid

  • This combination may interact with aminoglycosides (such as gentamicin and amikacin), loop diuretics (including furosemide and bumetanide), live vaccines (like oral typhoid vaccine), and anticoagulants (such as warfarin).

Overdose and Missed Dose

  • An overdose of Cefepime + Sulbactam may result in increased severity of side effects such as confusion, seizures, or severe diarrhoea. Immediate medical attention should be sought if an overdose is suspected.

  • If you miss a dose of Cefepime + Sulbactam, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage nausea, try taking the medicine with food or water.

  • If experiencing injection site discomfort, alternating the injection site may help reduce irritation.

Use in Driving and Operating Machinery

  • Cefepime + Sulbactam can cause dizziness or drowsiness in some individuals. You should avoid driving or operating heavy machinery if you experience these side effects after receiving this medicine.

Use in Pregnancy and Lactation

  • Cefepime + Sulbactam should only be used during pregnancy and lactation if clearly needed. Consult your doctor before receiving this medication.

Caution in Other Conditions

  • Patients with renal impairment should exercise caution when using Cefepime + Sulbactam due to the need for dosage adjustment and potential accumulation of the medicine.

  • Individuals with a history of gastrointestinal diseases linked to antibiotic use should also use this medication cautiously due to the risk of Clostridium difficile-associated diarrhoea.

Special Dietary and Lifestyle Recommendations

  • Maintain adequate hydration while taking this medication to help prevent kidney issues that can arise from toxicity, especially when using other medicines like loop diuretics simultaneously.

  • Incorporate a balanced fibre-rich diet to help manage potential gastrointestinal side effects such as nausea or abdominal pain.

  • Practice good personal hygiene and proper wound care to support recovery from skin infections being treated by this medication.

  • Rest adequately while undergoing treatment to support immune function and recovery from infection.

Frequently asked questions

Yes, Cefepime + Sulbactam is a combination antibiotic. It contains cefepime, which belongs to a group of medications known as fourth-generation cephalosporins, and sulbactam, a beta-lactamase inhibitor.

While there's no absolute contraindication to having a small amount of alcohol with Cefepime + Sulbactam, it's best to avoid alcohol during your course of treatment to ensure optimal recovery and minimise potential side effects.

Yes, Cefepime + Sulbactam can cause allergic reactions in individuals who are hypersensitive to cefepime, sulbactam or other beta-lactam antibiotics.

If you experience severe side effects such as severe diarrhoea, skin reactions, seizures or blood disorders while taking Cefepime + Sulbactam, consult your doctor immediately.

No, Cefepime + Sulbactam is an antibiotic and works against bacterial infections only. It will not work for viral infections like the common cold or flu.

Certain medications such as aminoglycosides, loop diuretics and warfarin may interact with Cefepime + Sulbactam. Always inform your doctor about all the medications you are currently taking before starting this therapy.

Due to the lack of detailed studies on the combination of Cefepime and Sulbactam regarding fertility, it is recommended to discuss any concerns with your doctor, especially if you're planning to conceive or are currently dealing with fertility issues.

Terms & Conditions


Available medicines for CEFEPIME + SULBACTAM
Axipime S 1000/500 MG Injection 1
Axipime S 1000/500 MG Injection 1
Axis Life Science Pvt Ltd
Pack of 1 UNIT
₹278.80
MRP ₹340.00
18.00% OFF
Supime 1000/500 MG Injection 10 ML
Supime 1000/500 MG Injection 10 ML
Venus Remedies Ltd
Pack of 10 ML
₹301.76
MRP ₹368.00
18.00% OFF
Befsul 1.5 GM Injection 1
Befsul 1.5 GM Injection 1
Bayberry Pharmaceuticals Pvt Ltd
Pack of 1 Units
₹223.86
MRP ₹273.00
18.00% OFF
Supime 500/250 MG Injection 10 ML
Supime 500/250 MG Injection 10 ML
Venus Remedies Ltd
Pack of 10 ML
₹110.70
MRP ₹135.00
18.00% OFF
Supime 2000/1000 MG Injection 1
Supime 2000/1000 MG Injection 1
Venus Remedies Ltd
Pack of 1 Units
₹397.70
MRP ₹485.00
18.00% OFF

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