The primary use of Calcium Folinate is to decrease the harmful effects of certain medicines like methotrexate that are used in cancer treatment and management of autoimmune disorders. It belongs to the class of medications known as antidotes.
Secondary uses of Calcium Folinate include managing folate deficiency anaemia when oral folic acid cannot be used, and enhancing the effectiveness of certain anti-cancer medicines such as 5-fluorouracil.
Allergic reactions (rash, itching)
Gastrointestinal disturbances (nausea, vomiting)
Fatigue or weakness
Headache
Dizziness
Calcium Folinate is a form of reduced folic acid.
Once it enters the body, Calcium Folinate is converted into its active form, tetrahydrofolic acid (THF). THF acts as a 'one-carbon donor' which means it contributes carbon atoms to metabolic reactions that are crucial for the synthesis of DNA and RNA.
By providing this essential carbon atom for these reactions, Calcium Folinate ensures normal cell division and function can continue even when there are folic acid antagonists such as methotrexate in the body. This plays a key role in managing the toxicity effects of these antagonists.
In cases of folate deficiency anaemia, where the body lacks sufficient folic acid to make red blood cells, Calcium Folinate aids in replenishing folate stores and supports red blood cell maturation. This helps restore normal function to the production of red blood cells.
Doctor of Medicine
BMS, FMC, MD Resident
Calcium Folinate is available in two main formulations.
It can be administered as an injectable solution via intramuscular (IM) or intravenous (IV) routes.
It is also available as tablets for oral administration.
Calcium Folinate is suitable for use in both adults and children, with the specific age and dosage restrictions to be determined by the treating doctor based on the individual patient's medical condition and response to treatment.
Calcium Folinate is contraindicated in patients who have a known hypersensitivity to folinate or folic acid derivatives.
It should not be used in treating pernicious anaemia or other megaloblastic anaemias that are caused by a vitamin B12 deficiency.
Calcium Folinate may interact with certain medications such as antiepileptic drugs (phenobarbital, phenytoin, primidone), antibiotics (sulfamethoxazole-trimethoprim), and chemotherapy agents (like 5-fluorouracil).
An overdose of Calcium Folinate could lead to severe side effects such as allergic reactions or gastrointestinal disturbances. In such situations, it is crucial to consult your doctor immediately.
If you miss a dose of Calcium Folinate, take it as soon as you remember. However, If it is close to the time for your next dose, skip the missed dose and return to your normal dosing schedule.
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For nausea and vomiting, try taking the medicine with or after a meal.
If you experience fatigue or weakness, ensure you are getting enough rest and staying properly hydrated.
Calcium Folinate may cause side effects like dizziness or fatigue that could affect your ability to drive or operate heavy machinery. It is advised to avoid such activities if you experience these side effects.
Pregnant or breastfeeding women should consult their doctor before using Calcium Folinate. Its use should be carefully considered based on the benefits and potential risks.
Patients with a history of allergic reactions to folate or folinic acid should exercise caution while using Calcium Folinate.
Those with pernicious anaemia, vitamin B12 deficiency, or renal impairment may also require dose adjustment or close monitoring when taking this medicine.
A balanced diet rich in folic acid can help manage underlying conditions that Calcium Folinate is used to treat. Foods like leafy green vegetables, fruits, beans, cereals, and breads are excellent sources of folic acid.
Regular check-ups and blood tests are recommended to monitor the effectiveness of the treatment and any potential side effects.
Avoiding alcohol and tobacco can also contribute towards overall health improvement.
Frequently asked questions
No, Calcium Folinate is not the same as folic acid. Although they both belong to the vitamin B group, Calcium Folinate is a form of folic acid that is directly active in the body, while folic acid requires conversion into its active form in the body.
There is no documented evidence suggesting that Calcium Folinate can cause weight gain. However, individual responses to medication can vary, and if you notice unexplained weight changes, consult your doctor.
A balanced diet rich in leafy green vegetables, citrus fruits, and beans can provide natural sources of folate, the nutrient that Calcium Folinate replenishes. However, these foods may not provide sufficient folate in certain medical conditions, for which Calcium Folinate may be prescribed.
While there's no conclusive studies indicating that Calcium Folinate directly affects mood or behaviour, deficiencies in folate have been associated with mental health issues like depression and cognitive dysfunction. Consult your doctor for any concerns regarding mood changes while taking this medicine.
Some people may experience dizziness as a side effect of Calcium Folinate, but it does not typically cause drowsiness or sleep problems.
There are no specific restrictions on alcohol consumption with Calcium Folinate mentioned in the medical literature. However, alcohol can interfere with nutrient absorption and may exacerbate conditions for which this medication is prescribed.
The safety of the long-term use of Calcium Folinate depends on the condition being managed and your individual health circumstances. Always follow your doctor's instructions regarding the duration of medication use.
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