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Benzalkonium Chloride + Fluconazole

Uses of Benzalkonium Chloride + Fluconazole

  • The primary use of Benzalkonium Chloride + Fluconazole is to manage fungal eye infections such as keratitis and conjunctivitis. It belongs to the groups of antimicrobial preservatives and antifungal medications.

  • Secondary uses include being part of some fluconazole oral suspensions as a preservative, and it is rarely used as a solubilizing agent in fluconazole injections.

Side effects of Benzalkonium Chloride + Fluconazole

  • Nausea

  • Abdominal pain

  • Diarrhoea

  • Headache

  • Skin rash

How Benzalkonium Chloride + Fluconazole works

  • Benzalkonium Chloride + Fluconazole is a combination of an antimicrobial preservative and an antifungal medicine.

  • Benzalkonium chloride is a quaternary ammonium compound. It uncouples the bacterial cell membrane, leading to the leakage of cellular contents. Additionally, it deactivates enzymes that are vital for the cell's respiratory and metabolic functions. This results in the death of bacteria and fungi.

  • Fluconazole is an azole antifungal medication. It works by blocking the synthesis of fungal cell membranes, thereby inhibiting the growth and reproduction of fungi.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage forms available

  • Benzalkonium Chloride + Fluconazole is available for use in ophthalmic (eye) preparations, specifically as eye drops formulated to address fungal infections of the eye.

Age and dose restrictions

  • This medicine is intended for use by adults.

Contraindications

  • This medicine is contraindicated in patients with hypersensitivity to Fluconazole or other azole antifungals.

Other medications to avoid

  • This combination may interact with other topical antifungals (such as clotrimazole), preservatives in ocular or topical formulations, and additional antiseptics (like chlorhexidine).

  • Before commencing any new medication, consulting a doctor is crucial to avoid potential interactions.

Overdose and missed dose

  • An overdose of Benzalkonium Chloride + Fluconazole could potentially exacerbate the side effects associated with each component. If excessive eye drop usage occurs, rinse your eyes with clean water at room temperature. If symptoms persist or worsen after applying more than the recommended dose of eye drops, inform your doctor.

  • If a dose of this medicine is missed, apply or take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Adjusting the timing of medication might help manage minor side effects effectively.

  • Ensuring adequate hydration by drinking water can also help mitigate some side effects.

Use in driving and operating machinery

  • The usage of Benzalkonium Chloride + Fluconazole in eye drop form may cause temporarily blurred vision. It is advisable to avoid driving or operating heavy machinery immediately after application until your vision is clear.

Use in pregnancy and lactation

  • The use of Benzalkonium Chloride + Fluconazole during pregnancy and lactation should be approached with caution. Consulting a doctor before using this medicine in these conditions is recommended due to potential risks to the fetus or nursing infant.

Caution in other conditions

  • Patients with renal (kidney) or hepatic (liver) impairment should use Benzalkonium Chloride + Fluconazole with caution due to possible alterations in medicinal metabolism and excretion.

Special dietary and lifestyle recommendations

  • Maintain good personal hygiene to help manage fungal infections effectively.

  • Avoid environments that are excessively warm or moist, which can foster fungal growth.

  • Wearing breathable, loose-fitting clothing can reduce moisture buildup on skin surfaces, which is conducive to fungal growth.

  • In cases of eye infections, ensure that eye makeup or contact lenses are not used during the treatment period to prevent further irritation or spread of infection.

Frequently asked questions

Benzalkonium Chloride + Fluconazole is not typically used for bacterial infections. The combination primarily targets fungal infections, with benzalkonium chloride acting as a preservative and fluconazole serving as an antifungal agent.

There is no evidence to suggest that Benzalkonium Chloride + Fluconazole directly affects mood. However, if any psychological changes are noticed while taking this medication, it is recommended to consult with your doctor.

Weight gain is not a common side effect associated with Benzalkonium Chloride + Fluconazole. If you notice unexpected weight changes while taking this medication, please consult your doctor.

The active ingredients in Benzalkonium Chloride + Fluconazole are chemically synthesised and not derived from animal products. However, it is advisable to check the excipients or inactive ingredients listed on the package for any animal-derived substances.

The combination of Benzalkonium Chloride and Fluconazole does not have any known significant interactions with food. However, as with all medicines, it should be taken as directed by your doctor.

The combination of Benzalkonium Chloride and Fluconazole does not carry a known risk of dependency or withdrawal. However, it is important to take the medication for the duration prescribed by your doctor.

Anyone with a known allergy to either benzalkonium chloride or fluconazole should avoid this medication. If you experience an allergic reaction, such as rash, itching or swelling, while using this medicine, seek immediate medical attention.

Terms & Conditions


Benzalkonium Chloride + Fluconazole in other salts

FLUCONAZOLEFLUCONAZOLE + TINIDAZOLEAZITHROMYCIN + FLUCONAZOLE + SECNIDAZOLEBENZALKONIUM CHLORIDE + CHOLINE SALICYLATE + LIDOCAINE / LIGNOCAINEBENZALKONIUM CHLORIDE + ZINC OXIDEBENZALKONIUM CHLORIDE + BROMFENAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + OFLOXACINBENZALKONIUM CHLORIDE + CYCLOPENTOLATEBENZALKONIUM CHLORIDE + CIPROFLOXACINBENZALKONIUM CHLORIDE + CIPROFLOXACIN + DEXAMETHASONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONE + TOBRAMYCINBENZALKONIUM CHLORIDE + GATIFLOXACINBENZALKONIUM CHLORIDE + DEXAMETHASONE + OFLOXACINBENZALKONIUM CHLORIDE + NEPAFENACBENZALKONIUM CHLORIDE + MOXIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + TOBRAMYCINBENZALKONIUM CHLORIDE + CHOLINE SALICYLATEBENZALKONIUM CHLORIDE + DEXAMETHASONE + TOBRAMYCINBENZALKONIUM CHLORIDE + BRIMONIDINE + TIMOLOLALCAFTADINE + BENZALKONIUM CHLORIDEBENZALKONIUM CHLORIDE + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + KETOROLAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + LATANOPROSTBENZALKONIUM CHLORIDE + OLOPATADINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + BRIMONIDINEBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEBENZALKONIUM CHLORIDE + BEPOTASTINEBENZALKONIUM CHLORIDE + BRIMONIDINE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + BIMATOPROSTBENZALKONIUM CHLORIDE + BIMATOPROST + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + CYCLOSPORINBENZALKONIUM CHLORIDE + KETOROLAC + OLOPATADINEBENZALKONIUM CHLORIDE + DORZOLAMIDEBENZALKONIUM CHLORIDE + DORZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + GATIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + LATANOPROST + TIMOLOLBENZALKONIUM CHLORIDE + LOTEPREDNOLBENZALKONIUM CHLORIDE + LOTEPREDNOL + TOBRAMYCINBENZALKONIUM CHLORIDE + DEXAMETHASONE + MOXIFLOXACINBENZALKONIUM CHLORIDE + LOTEPREDNOL + MOXIFLOXACINBENZALKONIUM CHLORIDE + BROMFENACBENZALKONIUM CHLORIDE + MOXIFLOXACINBENZALKONIUM CHLORIDE + OLOPATADINEBENZALKONIUM CHLORIDE + PREDNISOLONEBENZALKONIUM CHLORIDE + TIMOLOL + TRAVOPROSTBENZALKONIUM CHLORIDE + TRAVOPROSTBENZALKONIUM CHLORIDE + NATAMYCINBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + NETARSUDILAZITHROMYCIN + FLUCONAZOLE + ORNIDAZOLEBENZALKONIUM CHLORIDE + GANCYCLOVIR
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